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公开(公告)号：WO2020092375A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058573
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: C07D215/14 , C07D215/18 , C07D215/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D475/02 , C07D491/06 , A61K31/47 , A61P29/00
Abstract: The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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2.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 审中-公开苯并咪唑衍生物及其作为磷脂酰肌醇3-激酶抑制剂的用途
公开(公告)号：WO2018057810A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/052820
申请日：2017-09-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CHANDRASEKHAR, Jayaraman , PERREAULT, Stephane , PATEL, Leena , PHILLIPS, Gary , TILL, Nicholas, Alexander , TREIBERG, Jennifer, Anne
IPC: C07D401/14 , A61K31/4184 , A61K31/4196 , A61K31/4409 , A61K31/4709 , A61K31/506 , A61K31/519 , C07D487/02 , A61P29/00 , A61P35/00
Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as described herein. The compounds of formula I selectively inhibit the activities of PI3K isoforms and are therefore useful in therapeutic treatments, in particular in the treatment of cancer and inflammatory conditions.
Abstract translation: 本申请提供了式I化合物或其药学上可接受的盐，异构体，互变异构体或其混合物，其中s，t，n，R 1，R 2， R 2，R 3，R 4，R 5和R 6如上所述是 在此描述。 式I化合物选择性地抑制PI3K亚型的活性，因此可用于治疗性治疗，特别是用于治疗癌症和炎症性疾病。
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公开(公告)号：WO2018057808A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/052817
申请日：2017-09-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CHANDRASEKHAR, Jayaraman , CODELLI, Julian, Andrew , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Gary , SEDILLO, Kassandra, F. , TREIBERG, Jennifer, Anne , VAN VELDHUIZEN, Joshua , WATKINS, William, J.
IPC: C07D413/14 , A61K31/4184 , A61K31/4196 , A61K31/4709 , A61K31/5375 , C07D413/04 , A61P29/00 , A61P35/00 , C07D405/14 , A61K31/341 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , C07D409/14 , C07D417/14
Abstract: The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as described herein. The compounds of formula I or IA selectively inhibit the activities of PI3K isoforms and are therefore useful in therapeutic treatments, in particular in the treatment of cancer and inflammatory conditions.
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4.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 审中-公开苯并咪唑衍生物及其作为磷脂酰肌醇3-激酶抑制剂的用途
公开(公告)号：WO2018057808A8
公开(公告)日：2018-03-29
申请号：PCT/US2017/052817
申请日：2017-09-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CHANDRASEKHAR, Jayaraman , CODELLI, Julian, Andrew , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Gary , SEDILLO, Kassandra, F. , TREIBERG, Jennifer, Anne , VAN VELDHUIZEN, Joshua , WATKINS, William, J.
IPC: C07D413/14 , A61K31/4184 , A61K31/4196 , A61K31/4709 , A61K31/5375 , C07D413/04 , A61P29/00 , A61P35/00 , C07D405/14 , A61K31/341 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , C07D409/14 , C07D417/14
Abstract: The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as described herein. The compounds of formula I or IA selectively inhibit the activities of PI3K isoforms and are therefore useful in therapeutic treatments, in particular in the treatment of cancer and inflammatory conditions.
Abstract translation: 本申请提供了式I或IA的化合物或其药学上可接受的盐，异构体，互变异构体或其混合物，其中s，t，m，n，R 1， R 2，R 3，R 4，R 5，R 6，R 5，R 5，R 5，R 5， 和R 7如本文所述。 式I或IA化合物选择性抑制PI3K亚型的活性，因此可用于治疗性治疗，特别是用于治疗癌症和炎症性疾病。
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5.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 审中-公开苯并咪唑衍生物及其作为磷脂酰肌醇3-激酶抑制剂的用途
公开(公告)号：WO2018057805A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/052811
申请日：2017-09-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CHANDRASEKHAR, Jayaraman , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Gary , SEDILLO, Kassandra, F. , TILL, Nicholas, Alexander , TREIBERG, Jennifer, Anne , WATKINS, William, J.
IPC: C07D413/14 , A61K31/4184 , A61K31/4196 , A61K31/4709 , A61K31/5375 , C07D413/04 , A61P29/00 , A61P35/00
Abstract: The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein t, R 1 , R 2 , R 3 , R 4 , and R 6 are as described herein. The compounds of formula I selectively inhibit the activities of PI3K isoforms and are useful in therapeutic treatments, in particular in the treatment of inflammatory diseases and cancer.
Abstract translation: 本申请提供了式I化合物或其药学上可接受的盐，异构体，互变异构体或其混合物，其中t，R 1，R 2， R 3，R 4和R 6如本文所述。 式I化合物选择性抑制PI3K亚型的活性，并且可用于治疗性治疗，特别是用于治疗炎性疾病和癌症。
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Patent Agency Ranking
公开(公告)号：WO2023076983A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/078759
申请日：2022-10-27
Applicant: GILEAD SCIENCES, INC.
Inventor： BALAN, Gayatri , CHANDRASEKHAR, Jayaraman , CHANG, Jonah J. , CURRIE, Kevin S. , HOLMBO, Stephen D. , JACOBSEN, Jesse M. , KROPF, Jeffrey E. , LEE, Seung H. , MOAZAMI, Yasamin , PATEL, Leena B. , PAUL, Thomas J. , PERREAULT, Stephane , SALVO, Patrick J. , TREIBERG, Jennifer A. , WEAVER, Heath A.
IPC: C07D403/08 , C07D403/12 , C07D413/14 , C07D487/04 , A61P35/00 , A61K31/501 , A61K31/502 , A61K31/5025
Abstract: Provided herein is a compound of Formula (I) wherein the various substituents are described herein.
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公开(公告)号：WO2020237025A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033955
申请日：2020-05-21
Applicant: GILEAD SCIENCES, INC.
Inventor： AKTOUDIANAKIS, Evangelos , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , ELBEL, Kristyna M. , KALLA, Rao V. , METOBO, Samuel E. , MITCHELL, Scott A. , PERRY, Thao , SIMONOVICH, Scott P. , ZIEBENHAUS, Christopher A.
IPC: A61P35/00 , C07D413/14 , C07D498/04 , A61K31/538 , A61K31/5383
Abstract: The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：WO2020092621A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058932
申请日：2019-10-30
Applicant: GILEAD SCIENCES, INC.
Inventor： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KASUN, Zachary A. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , SWAMINATHAN, Sundaramoorthi , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC: C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00
Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：WO2020092383A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058583
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: C07D405/04 , C07C233/87 , C07D215/12 , C07D215/227 , C07D265/36 , C07D307/87 , C07D311/04 , C07D311/58 , C07D311/94 , C07D319/18 , C07D321/10 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04 , A61K31/4709 , A61P29/00
Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2020092528A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058813
申请日：2019-10-30
Applicant: GILEAD SCIENCES, INC.
Inventor： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC: A61P31/18 , A61P31/20 , A61P35/00 , C07D471/04 , C07D519/00 , A61K31/444 , A61K31/4545
Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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