公开(公告)号：WO2021097540A1

公开(公告)日：2021-05-27

申请号：PCT/AU2020/051269

申请日：2020-11-23

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  STANISIC, Danielle ,  GIDDAM, Ashwini Kumar ,  SSEMEGANDA, Aloysious

IPC分类号： A61K39/015 ,  A61K39/018 ,  A61K9/127 ,  A61K47/69 ,  A61P33/06

摘要： Disclosed are compositions for stimulating a protective or therapeutic immune response to an apicomplexan parasite such as those from the Plasmodium or Babesia genus. More particularly, the compositions comprise a soluble parasite extract. The extract may be free of red blood cell components and/or contained in or associated with a particle such as a liposome. The compositions and methods disclosed herein are particularly useful in the prevention and treatment of parasitic diseases.

公开(公告)号：WO2022236370A1

公开(公告)日：2022-11-17

申请号：PCT/AU2022/050447

申请日：2022-05-11

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  AL-NAZAL, Hanan ,  STANISIC, Danielle

IPC分类号： A61K35/18 ,  A61K39/018 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P33/02 ,  A61P33/06

摘要： The present application is directed to compositions used in vaccinating mammals against erythrocytic organism infection, or treating erythrocytic infection. These compositions comprising erythrocytes and an erythrocytic organism, wherein the erythrocytes are derived from a mammalian species different to the mammalian species being administered the composition. The compositions are used to raise immune responses to infection with organisms such as Babesia sp., Anaplasma, Erlichia, Mycoplasma or Plasmodium for example, particularly Babesia sp. such as B. canis or B. divergens.

公开(公告)号：WO2018049459A1

公开(公告)日：2018-03-22

申请号：PCT/AU2016/050998

申请日：2016-10-24

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  STANISIC, Danielle ,  LOW, Leanne

IPC分类号： A61K39/015 ,  A61K39/018 ,  A61P33/02 ,  A61P33/06

CPC分类号： A61K39/018 ,  A01K67/0273 ,  A01K2207/12 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/435 ,  A61K31/65 ,  A61K31/7056 ,  A61K39/002 ,  A61K39/015 ,  A61K2039/521 ,  A61K2039/70 ,  A61P33/02 ,  A61P33/06 ,  Y02A50/412

摘要： Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan parasites. This allows the elicitation of an immune response by the animal while preventing the parasites producing a serious infection of the animal. The apicomplexan parasites may be malaria or babesia parasites. The delayed death agent may be a tetracycline class antibiotic, a macrolide antibiotic or a lincosamide antibiotic.

摘要翻译：

将Apicomplexan寄生虫或感染了apicomplexan寄生虫的红细胞与延迟死亡剂联合给予动物，最初允许寄生虫复制，但随后杀死apicomplexan寄生虫。 这允许动物引发免疫应答，同时防止寄生虫产生严重的动物感染。 apicomplexan寄生虫可能是疟疾或巴贝虫寄生虫。 延迟死亡剂可以是四环素类抗生素，大环内酯类抗生素或林可酰胺类抗生素。