公开(公告)号：WO2022160017A1

公开(公告)日：2022-08-04

申请号：PCT/AU2022/050050

申请日：2022-02-01

申请人： GRIFFITH UNIVERSITY ,  GOLD COAST HOSPITAL AND HEALTH SERVICE

发明人： GOOD, Michael ,  PANDEY, Manisha ,  GERRARD, John Gregory

IPC分类号： A61K39/215 ,  A61K39/295 ,  A61P31/14 ,  C07K14/005

摘要： The present disclosure provides immunogenic compositions and methods of inducing an immune response and/or preventing, treating or ameliorating an infection, disease or condition associated with SARS-CoV-2 in a subject with such immunogenic compositions.

公开(公告)号：WO2019218022A1

公开(公告)日：2019-11-21

申请号：PCT/AU2019/050469

申请日：2019-05-16

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  PANDEY, Manisha

IPC分类号： A61K39/09 ,  A61K39/40 ,  C07K16/12 ,  C07K14/315

摘要： Provided herein are methods of immunizing against, treating or preventing streptococcal toxic shock syndrome in a subject, by administration of a group A streptococcus M protein, inclusive of fragments, variants or derivatives thereof, or an antibody that binds, or is raised against the M protein and optionally a group A streptococcus superantigen protein, inclusive of fragments, variants or derivatives thereof, or an antibody or antibody fragment that binds, or is raised against, the superantigen protein.

公开(公告)号：WO2012162731A1

公开(公告)日：2012-12-06

申请号：PCT/AU2012/000594

申请日：2012-05-28

申请人： GRIFFITH UNIVERSITY ,  La Trobe University ,  LEE, Moses ,  GOOD, Michael ,  SPITHILL, Terry

发明人： LEE, Moses ,  GOOD, Michael ,  SPITHILL, Terry

IPC分类号： A61K39/015 ,  A61P33/06

CPC分类号： A61K39/015 ,  A61K2039/522 ,  C07K14/445 ,  Y02A50/412

摘要： An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.

摘要翻译： 提供用作血液疟疾疫苗的免疫原性组合物，产生免疫原性组合物的方法和治疗疟疾的方法。 免疫原性组合物包括分离的或纯化的裂殖子或用裂殖酵母感染的红细胞，用百吗那霉素A或托伐他霉素A处理。免疫原性组合物不包括佐剂。 单一剂量的免疫原性组合物足以保护动物免受在免疫原性组合物中使用的相同的分离物，菌株或疟原虫物种的后续疟疾感染，或通过一种或多种异源分离物，菌株或疟原虫物种。

公开(公告)号：WO2021097540A1

公开(公告)日：2021-05-27

申请号：PCT/AU2020/051269

申请日：2020-11-23

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  STANISIC, Danielle ,  GIDDAM, Ashwini Kumar ,  SSEMEGANDA, Aloysious

IPC分类号： A61K39/015 ,  A61K39/018 ,  A61K9/127 ,  A61K47/69 ,  A61P33/06

摘要： Disclosed are compositions for stimulating a protective or therapeutic immune response to an apicomplexan parasite such as those from the Plasmodium or Babesia genus. More particularly, the compositions comprise a soluble parasite extract. The extract may be free of red blood cell components and/or contained in or associated with a particle such as a liposome. The compositions and methods disclosed herein are particularly useful in the prevention and treatment of parasitic diseases.

公开(公告)号：WO2015013739A1

公开(公告)日：2015-02-05

申请号：PCT/AU2014/000750

申请日：2014-07-25

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael

IPC分类号： A61K39/018 ,  A61P33/00

CPC分类号： A61K39/018 ,  A61K2039/522

摘要： An immunogenic composition and method of producing an immunogenic composition include isolated or purified blood-stage Babesia parasites, or red blood cells infected with blood-stage Babesia parasites, treated with tafuramycin A or an analog or derivative thereof. Typically, the blood-stage Babesia parasites are, or include, any form of the parasite that exists within red blood cells, including but not limited to merozoites. The immunogenic composition is used for the treatment or prophylaxis of babesiosis in mammals such as bovines.

摘要翻译： 免疫原性组合物和产生免疫原性组合物的方法包括用塔非霉素A或其类似物或衍生物处理的分离或纯化的血液阶段巴贝虫寄生虫或感染血液阶段巴贝虫寄生虫的红细胞。 通常，血液阶段巴贝虫寄生虫是或包括存在于红细胞内的任何形式的寄生虫，包括但不限于裂殖子。 免疫原性组合物用于治疗或预防哺乳动物例如牛中的婴儿败血症。

公开(公告)号：WO2022236370A1

公开(公告)日：2022-11-17

申请号：PCT/AU2022/050447

申请日：2022-05-11

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  AL-NAZAL, Hanan ,  STANISIC, Danielle

IPC分类号： A61K35/18 ,  A61K39/018 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P33/02 ,  A61P33/06

摘要： The present application is directed to compositions used in vaccinating mammals against erythrocytic organism infection, or treating erythrocytic infection. These compositions comprising erythrocytes and an erythrocytic organism, wherein the erythrocytes are derived from a mammalian species different to the mammalian species being administered the composition. The compositions are used to raise immune responses to infection with organisms such as Babesia sp., Anaplasma, Erlichia, Mycoplasma or Plasmodium for example, particularly Babesia sp. such as B. canis or B. divergens.

公开(公告)号：WO2015157820A1

公开(公告)日：2015-10-22

申请号：PCT/AU2015/050174

申请日：2015-04-15

申请人： GRIFFITH UNIVERSITY

发明人： PANDEY, Manisha ,  BATZLOFF, Michael ,  GOOD, Michael

IPC分类号： A61K39/09 ,  A61K39/40 ,  C07K4/04 ,  C07K14/315 ,  C07K16/12 ,  A61P31/04

CPC分类号： C07K14/315 ,  A61K38/4873 ,  A61K39/092 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/1275 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C12Y304/22

摘要： A method and composition for eliciting an immune response to group A streptococcal bacteria in a mammal is provided, which includes administering to the mammal an M protein fragment, variant or derivative thereof and a SpyCEP protein or peptide fragment, or an antibody to the SpyCEP protein or fragment to facilitate restoring or enhancing neutrophil activity. Also provided is an immunodominant peptide fragment of SpyCEP.

摘要翻译： 提供了一种用于在哺乳动物中引起对A组链球菌细菌的免疫应答的方法和组合物，其包括向哺乳动物施用M蛋白片段，其变体或衍生物和SpyCEP蛋白或肽片段或对SpyCEP蛋白的抗体 或片段以促进中性粒细胞活性的恢复或增强。 还提供了SpyCEP的免疫显性肽片段。

公开(公告)号：WO2018049459A1

公开(公告)日：2018-03-22

申请号：PCT/AU2016/050998

申请日：2016-10-24

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  STANISIC, Danielle ,  LOW, Leanne

IPC分类号： A61K39/015 ,  A61K39/018 ,  A61P33/02 ,  A61P33/06

CPC分类号： A61K39/018 ,  A01K67/0273 ,  A01K2207/12 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/435 ,  A61K31/65 ,  A61K31/7056 ,  A61K39/002 ,  A61K39/015 ,  A61K2039/521 ,  A61K2039/70 ,  A61P33/02 ,  A61P33/06 ,  Y02A50/412

摘要： Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan parasites. This allows the elicitation of an immune response by the animal while preventing the parasites producing a serious infection of the animal. The apicomplexan parasites may be malaria or babesia parasites. The delayed death agent may be a tetracycline class antibiotic, a macrolide antibiotic or a lincosamide antibiotic.

摘要翻译：

将Apicomplexan寄生虫或感染了apicomplexan寄生虫的红细胞与延迟死亡剂联合给予动物，最初允许寄生虫复制，但随后杀死apicomplexan寄生虫。 这允许动物引发免疫应答，同时防止寄生虫产生严重的动物感染。 apicomplexan寄生虫可能是疟疾或巴贝虫寄生虫。 延迟死亡剂可以是四环素类抗生素，大环内酯类抗生素或林可酰胺类抗生素。