公开(公告)号：WO1996041845A1

公开(公告)日：1996-12-27

申请号：PCT/US1996009917

申请日：1996-06-07

Applicant: IGEN, INC.

Inventor： IGEN, INC. ,  JAMEISON, Fabian ,  LELAND, Jonathan, K.

IPC: C09K03/00

CPC classification number: C12Q1/60 ,  C01B15/01 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/76 ,  G01N33/582 ,  Y10S436/805

Abstract: The invention is directed to processes and compositions useful for detecting the presence and/or the amount of reagents including H2O2, H2O2-producing components, or H2O2-consuming components via modulation effects that these reagents have upon the oxidative-reduction electrochemiluminescent reaction mechanism among the oxalate anion (C2O4 ) and ruthenium (II)tris(2, 2'-bipyridine).

Abstract translation: 本发明涉及用于通过这些试剂对氧化还原电化学发光反应机理的调节作用来检测包括H 2 O 2，H 2 O 2产生组分或H2O2消耗组分的试剂的存在和/或量的方法和组合物 草酸盐阴离子（C2O4 <＆amp; H2>）和钌（Ⅱ）三（2,2'-联吡啶）。

公开(公告)号：WO1997033176A1

公开(公告)日：1997-09-12

申请号：PCT/US1997003653

申请日：1997-03-05

Applicant: IGEN, INC.

Inventor： IGEN, INC. ,  MASSEY, Richard, J. ,  MARTIN, Mark, T. ,  DONG, Liwen ,  LU, Ming ,  FISCHER, Alan ,  JAMEISON, Fabian ,  LIANG, Pam ,  HOCH, Robert ,  LELAND, Jonathon, K.

IPC: G01N33/573

CPC classification number: C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  G01N2030/8863 ,  G11C13/025 ,  H01M4/60 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

Abstract translation: 石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“buckytubes”）和原纤维，被用作电致化学发光测定中的固体支持物。 石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。 电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。