摘要:
Provided herein are specific dosages and dosage schedules of a composition comprising at least one gluten peptide for use in treating subjects with Celiac disease.
摘要:
Provided herein are compositions and methods for treating subjects with Celiac disease, e.g., specific dosages and dosage schedules of a composition comprising at least gluten peptide for use in treating subjects with Celiac disease.
摘要:
Provided herein are compositions and methods for treating autoimmune diabetes such as type 1 diabetes (T1D), diagnosing autoimmune diabetes such as T1D, assessing treatment efficacy, and selecting subjects for treatment, e.g., using a peptide or epitope disclosed.
摘要:
Provided herein are methods and kits for assaying antigen-specific T cell responses, such as rare autoantigen- specific T cell responses, by measuring a level of IP- 10 in a sample from a subject having or suspected of having an autoimmune disease, an allergy, an infectious disease or condition, or an adverse immune condition caused by administration of an isolated, recombinant or synthetic protein or peptide. Also provided herein are methods and kits for assaying a T cell response to an antigen peptide, such as an islet autoantigen peptide, such as measuring a T cell response to at least one antigen peptide, such as an islet autoantigen peptide, in a sample from a subject, such as one having or suspected of having Type 1 Diabetes (TID), Celiac disease or both.
摘要:
Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (HLA) genotype, in particular HLA-DQ2.5 homozygosity, of a subject having or suspected of having Celiac disease. Also provided herein are methods of identifying (e.g., diagnosing) a subject, such as a subject having or suspected of having Celiac disease and/or assessing the efficacy of treatment of Celiac disease, e.g. by determining responsiveness to a therapeutic gluten peptide composition or cytokine response, and kits relating thereto.
摘要:
Provided herein compositions comprising gluten and methods of use thereof. In some aspects, compositions comprising ratios of wheat flour protein, rye flour protein, and barley flour protein are provided and methods of use thereof.