ESCALATING DOSAGE SCHEDULES FOR TREATING CELIAC DISEASE
    2.
    发明申请
    ESCALATING DOSAGE SCHEDULES FOR TREATING CELIAC DISEASE 审中-公开
    升级用于治疗CELIAC疾病的剂量时间表

    公开(公告)号:WO2018005700A1

    公开(公告)日:2018-01-04

    申请号:PCT/US2017/039834

    申请日:2017-06-28

    申请人: IMMUSANT, INC.

    IPC分类号: A61K38/16 A61P1/00

    摘要: Provided herein are specific dosages and dosage schedules of a composition comprising at least one gluten peptide for use in treating subjects with Celiac disease.

    摘要翻译: 本文提供了包含至少一种谷蛋白肽的组合物的具体剂量和剂量方案,所述组合物用于治疗患有乳糜泻的受试者。

    DOSING REGIMENS FOR CELIAC DISEASE
    4.
    发明申请

    公开(公告)号:WO2019089572A1

    公开(公告)日:2019-05-09

    申请号:PCT/US2018/058183

    申请日:2018-10-30

    申请人: IMMUSANT, INC.

    IPC分类号: A61K38/16 G01N33/68

    摘要: Provided herein are compositions and methods for treating subjects with Celiac disease, e.g., specific dosages and dosage schedules of a composition comprising at least gluten peptide for use in treating subjects with Celiac disease.

    PEPTIDES FOR USE IN TREATMENT AND DIAGNOSIS OF TYPE 1 DIABETES
    5.
    发明申请
    PEPTIDES FOR USE IN TREATMENT AND DIAGNOSIS OF TYPE 1 DIABETES 审中-公开
    用于治疗和诊断1型糖尿病的肽

    公开(公告)号:WO2016081869A2

    公开(公告)日:2016-05-26

    申请号:PCT/US2015/061931

    申请日:2015-11-20

    申请人: IMMUSANT, INC.

    摘要: Provided herein are compositions and methods for treating autoimmune diabetes such as type 1 diabetes (T1D), diagnosing autoimmune diabetes such as T1D, assessing treatment efficacy, and selecting subjects for treatment, e.g., using a peptide or epitope disclosed.

    摘要翻译: 本文提供了用于治疗自身免疫性糖尿病如1型糖尿病(T1D),诊断自身免疫性糖尿病如T1D,评估治疗功效和选择用于治疗的受试者的组合物和方法,例如使用肽或 表位披露。

    METHODS OF MEASURING ANTIGEN-SPECIFIC T CELLS
    6.
    发明申请
    METHODS OF MEASURING ANTIGEN-SPECIFIC T CELLS 审中-公开
    测量抗原特异性T细胞的方法

    公开(公告)号:WO2015164727A1

    公开(公告)日:2015-10-29

    申请号:PCT/US2015/027497

    申请日:2015-04-24

    申请人: IMMUSANT, INC.

    IPC分类号: G01N33/68 C07K16/18

    摘要: Provided herein are methods and kits for assaying antigen-specific T cell responses, such as rare autoantigen- specific T cell responses, by measuring a level of IP- 10 in a sample from a subject having or suspected of having an autoimmune disease, an allergy, an infectious disease or condition, or an adverse immune condition caused by administration of an isolated, recombinant or synthetic protein or peptide. Also provided herein are methods and kits for assaying a T cell response to an antigen peptide, such as an islet autoantigen peptide, such as measuring a T cell response to at least one antigen peptide, such as an islet autoantigen peptide, in a sample from a subject, such as one having or suspected of having Type 1 Diabetes (TID), Celiac disease or both.

    摘要翻译: 本文提供了通过测量具有或怀疑具有自身免疫性疾病的受试者的样品中的IP-10的水平,过敏的方法和试剂盒,用于测定抗原特异性T细胞应答,例如罕见的自身抗原特异性T细胞应答 ,感染性疾病或病症,或由分离的重组或合成的蛋白质或肽的给药引起的不良免疫状态。 本文还提供了用于测定对抗原肽(例如胰岛自身抗原肽)的T细胞应答的方法和试剂盒,例如测量对至少一种抗原肽(例如胰岛自身抗原肽)的T细胞对来自 例如具有或怀疑患有1型糖尿病(TID),腹腔疾病或两者的受试者。

    USE OF HLA GENETIC STATUS TO ASSESS OR SELECT TREATMENT OF CELIAC DISEASE
    7.
    发明申请
    USE OF HLA GENETIC STATUS TO ASSESS OR SELECT TREATMENT OF CELIAC DISEASE 审中-公开
    使用HLA遗传状态来评估或选择治疗CELIAC疾病

    公开(公告)号:WO2016054038A1

    公开(公告)日:2016-04-07

    申请号:PCT/US2015/052939

    申请日:2015-09-29

    申请人: IMMUSANT, INC.

    IPC分类号: C12Q1/68 G01N33/50 A61K38/10

    摘要: Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (HLA) genotype, in particular HLA-DQ2.5 homozygosity, of a subject having or suspected of having Celiac disease. Also provided herein are methods of identifying (e.g., diagnosing) a subject, such as a subject having or suspected of having Celiac disease and/or assessing the efficacy of treatment of Celiac disease, e.g. by determining responsiveness to a therapeutic gluten peptide composition or cytokine response, and kits relating thereto.

    摘要翻译: 本文提供了基于具有或疑似患有腹腔疾病的受试者的人类白细胞抗原(HLA)基因型,特别是HLA-DQ2.5纯合子来调节或选择麸质肽治疗的方法。 本文还提供了鉴定(例如,诊断)受试者的方法,例如具有或怀疑患有乳糜泻的受试者和/或评估治疗腹腔疾病的功效,例如, 通过确定对治疗性麸质肽组合物或细胞因子应答的响应性,以及与其相关的试剂盒。