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公开(公告)号：WO2022105855A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/131650
申请日：2021-11-19
发明人： HAN, Huifeng , GAO, Panliang , MA, Cunbo , WANG, Peng , LIU, Dan , LONG, Wei
IPC分类号： C07D215/00 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D487/10 , C07D487/08 , A61K31/47 , A61P35/00
摘要： Provided are KRAS G12D inhibitors of formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2022078416A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/123674
申请日：2021-10-14
发明人： LI, Runze , MA, Cunbo , LIAN, Zhenchang , XIONG, Jing , WANG, Yanping , LONG, Wei
IPC分类号： C07C227/14 , C07D209/10 , C07F9/06 , C07D317/40 , A61K31/66 , A61K31/404 , A61P35/00
摘要： Glutamine analogs, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：WO2023020523A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112931
申请日：2022-08-17
发明人： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4375 , A61P35/00
摘要： A compound of Formula (I), (II) or (III), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer are disclosed.
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公开(公告)号：WO2023020521A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112927
申请日：2022-08-17
发明人： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC分类号： C07D471/04 , A61K31/519 , A61K31/517 , A61P35/00
摘要： The invention relates to a compound of Formula (I), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer thereof, prodrug thereof, deuterated molecule thereof or conjugated form thereof; composition containing the same and the use thereof.
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公开(公告)号：WO2022105859A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/131690
申请日：2021-11-19
发明人： HAN, Huifeng , GAO, Panliang , ZHANG, Wenlong , MA, Cunbo , WANG, Peng , LIU, Dan , ZHANG, Hao , LONG, Wei
IPC分类号： C07D239/94 , C07D239/80 , C07D239/72 , A61K31/517 , A61P35/00
摘要： KRAS G12D inhibitors of Formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2022078462A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/123878
申请日：2021-10-14
发明人： LI, Runze , MA, Cunbo , LIAN, Zhenchang , XIONG, Jing , WANG, Yanping , LONG, Wei
IPC分类号： C07C227/14 , C07D209/10 , C07F9/06 , C07D317/40 , A61K31/66 , A61K31/404 , A61P35/00
摘要： Glutamine analogs are provided, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：WO2018172984A1
公开(公告)日：2018-09-27
申请号：PCT/IB2018/051973
申请日：2018-03-23
发明人： MA, Cunbo , GAO, Panliang , HU, Shaojing , XU, Zilong , HAN, Huifeng , WU, Xinping , KANG, Di , LONG, Wei
IPC分类号： C07D241/18 , C07D241/20 , C07D401/14 , C07D401/04 , C07D491/107 , C07D498/10 , C07D471/10 , A61K31/497 , A61P35/00 , A61P35/02
摘要： This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.
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公开(公告)号：WO2021239049A1
公开(公告)日：2021-12-02
申请号：PCT/CN2021/096306
申请日：2021-05-27
发明人： MA, Cunbo
IPC分类号： C07C245/12 , C07C245/20 , C07K5/00 , A61K31/655 , A61P35/00
摘要： A novel glutamine analogs shown as the formula (I), a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：WO2021023247A1
公开(公告)日：2021-02-11
申请号：PCT/CN2020/107279
申请日：2020-08-06
发明人： GAO, Panliang , MA, Cunbo , WANG, Peng , LIU, Dan
IPC分类号： C07D471/04 , C07D491/08 , A61K31/18 , A61K31/4523 , A61K31/44 , A61P35/00
摘要： A KRAS mutant protein inhibitor, as shown by formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2020063760A1
公开(公告)日：2020-04-02
申请号：PCT/CN2019/108181
申请日：2019-09-26
发明人： HAN, Huifeng , GAO, Panliang , MA, Cunbo , KANG, Di
IPC分类号： C07D401/14 , C07D401/12 , C07D401/04 , C07D401/06 , C07D405/14 , C07D498/10 , C07D471/10 , C07D221/20 , C07D241/18 , C07D241/20 , A61K31/497 , A61P35/00 , A61P35/02
摘要： Provided is a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided is a pharmaceutical composition comprising the said compound.
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