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公开(公告)号：WO2022105855A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/131650
申请日：2021-11-19
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： HAN, Huifeng , GAO, Panliang , MA, Cunbo , WANG, Peng , LIU, Dan , LONG, Wei
IPC: C07D215/00 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D487/10 , C07D487/08 , A61K31/47 , A61P35/00
Abstract: Provided are KRAS G12D inhibitors of formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2021057832A1
公开(公告)日：2021-04-01
申请号：PCT/CN2020/117316
申请日：2020-09-24
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： LI, Amin , LI, Sujing , WANG, Peng , DANG, Chaojie , LIU, Dan
IPC: C07D401/02 , C07D471/04 , C07D221/04 , A61K31/4375 , A61P35/00
Abstract: Privided is a KRAS mutant protein inhibitor, a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2023020523A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112931
申请日：2022-08-17
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC: C07D403/14 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4375 , A61P35/00
Abstract: A compound of Formula (I), (II) or (III), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer are disclosed.
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公开(公告)号：WO2023020521A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112927
申请日：2022-08-17
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC: C07D471/04 , A61K31/519 , A61K31/517 , A61P35/00
Abstract: The invention relates to a compound of Formula (I), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer thereof, prodrug thereof, deuterated molecule thereof or conjugated form thereof; composition containing the same and the use thereof.
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公开(公告)号：WO2022105859A1
公开(公告)日：2022-05-27
申请号：PCT/CN2021/131690
申请日：2021-11-19
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： HAN, Huifeng , GAO, Panliang , ZHANG, Wenlong , MA, Cunbo , WANG, Peng , LIU, Dan , ZHANG, Hao , LONG, Wei
IPC: C07D239/94 , C07D239/80 , C07D239/72 , A61K31/517 , A61P35/00
Abstract: KRAS G12D inhibitors of Formula (I), a composition containing the inhibitor and the use thereof.
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Patent Agency Ranking
公开(公告)号：WO2022188729A1
公开(公告)日：2022-09-15
申请号：PCT/CN2022/079476
申请日：2022-03-07
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： HAN, Huifeng , GAO, Panliang , MA, Cunbo , WANG, Peng , LONG, Wei , ZHANG, Hao , ZHANG, Lei , LIU, Dan
IPC: C07D498/16 , C07D498/22 , A61K31/553 , A61P35/00
Abstract: The disclosure relates to a KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2022184178A1
公开(公告)日：2022-09-09
申请号：PCT/CN2022/079487
申请日：2022-03-07
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： HAN, Huifeng , GAO, Panliang , MA, Cunbo , WANG, Peng , LONG, Wei , WANG, Yanping , ZHANG, Hao , LIU, Dan
IPC: C07D471/00 , C07D471/02 , C07D471/04 , C07D487/04 , C07D519/00 , C07D491/048 , A61K31/435 , A61K31/4375 , A61K31/517 , A61P35/00
Abstract: Provided are KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof.
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公开(公告)号：WO2023046135A1
公开(公告)日：2023-03-30
申请号：PCT/CN2022/121202
申请日：2022-09-26
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , ZHANG, Wei , LIU, Xiaoyu , WANG, Yanping , LONG, Wei
IPC: C07D498/14 , C07D498/22 , C07D498/16 , A61K31/55 , A61P35/00
Abstract: Provided are K-Ras mutant protein inhibitors of formula (I), a composition containing the same and the use thereof.
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公开(公告)号：WO2023020519A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112919
申请日：2022-08-17
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC: C07D401/14 , C07D403/04 , C07D471/04 , A61K31/519 , A61P35/00 , C07D413/04 , C07D417/14 , C07D487/04 , C07D519/00
Abstract: A Compound of formula (I) or (II), a stereoisomer thereof, an atropisomer, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer, a pharmaceutically acceptable salt of the atropisomer, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof is disclosed:
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公开(公告)号：WO2023020518A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112918
申请日：2022-08-17
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC: C07D471/04 , A61K31/519 , A61P35/00
Abstract: Provided herein is a compound of Formula (IB), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer thereof, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof; composition containing the same and the use thereof.
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