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1.发明申请FIBRONECTIN TYPE III REPEAT BASED PROTEIN SCAFFOLDS WITH ALTERNATIVE BINDING SURFACES 审中-公开具有替代性结合表面的FIBRONECTIN III型重复蛋白质蛋白
公开(公告)号：WO2013049275A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057436
申请日：2012-09-27
Applicant: JANSSEN BIOTECH, INC. , DIEM, Michael , JACOBS, Steven
Inventor： DIEM, Michael , JACOBS, Steven
CPC classification number: G01N33/6845 , C12N15/1044 , C40B30/04 , C40B40/08 , C40B50/06 , G01N2333/78
Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
Abstract translation: 基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗 和疾病和病症的诊断。
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公开(公告)号：WO2019224711A3
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054182
申请日：2019-05-21
Applicant: JANSSEN BIOTECH, INC.
Inventor： DIEM, Michael , GAUDET, Francois , MCDAID, Ronan , NAIR-GUPTA, Priyanka
IPC: C07K16/28 , A61K39/395 , A61P35/02
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：WO2016179518A3
公开(公告)日：2016-11-10
申请号：PCT/US2016/031260
申请日：2016-05-06
Applicant: JANSSEN BIOTECH, INC.
Inventor： ANDERSON, Glenn , CARDOSO, Rosa , DIEM, Michael , GAUDET, Francois , GOLDBERG, Shalom , HARMAN, Benjamin C. , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer , O'NEIL, Karyn , POMERANTZ, Steven C. , CHANDRA RAO, Galla , SPINKA-DOMS, Tracy , TEPLYAKOV, Alexey , WU, Sheng-Jiun , MOONEY, Jill , LUISTRO, Leopoldo
IPC: A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28
Abstract: Provided herein are isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
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公开(公告)号：WO2018111978A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/065983
申请日：2017-12-13
Applicant: JANSSEN BIOTECH, INC.
Inventor： DIEM, Michael , HAWKINS, Rebecca , JACOBS, Steven , SEPULVEDA, Manuel
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and them are useful in therapeutic and diagnostic applications.
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公开(公告)号：WO2017210425A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035442
申请日：2017-06-01
Applicant: JANSSEN BIOTECH, INC.
Inventor： DIEM, Michael , JACOBS, Steven , O'NEIL, Karyn , RUTKOSKI, Thomas
CPC classification number: A61K38/39 , A61K47/549 , A61K2039/505 , C07K14/78 , C07K16/18 , C07K16/40 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.
Abstract translation: 与血清白蛋白特异性结合的纤连蛋白III型结构域（FN3），能够编码血清白蛋白特异性FN3结构域的相关多核苷酸，表达FN3结构域的细胞，以及相关的载体，可检测地标记的FN3结构域 和融合到异源部分的FN3结构域可用于延长分子在诊断和治疗应用中的半衰期。
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Patent Agency Ranking6.发明申请PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) BISPECIFIC BINDING AGENTS AND USES THEREOF 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途
公开(公告)号：WO2016179518A2
公开(公告)日：2016-11-10
申请号：PCT/US2016/031260
申请日：2016-05-06
Applicant: JANSSEN BIOTECH, INC.
Inventor： ANDERSON, Glenn , CARDOSO, Rosa , DIEM, Michael , GAUDET, Francois , GOLDBERG, Shalom , HARMAN, Benjamin C. , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer , O'NEIL, Karyn , POMERANTZ, Steven C. , CHANDRA RAO, Galla , SPINKA-DOMS, Tracy , TEPLYAKOV, Alexey , WU, Sheng-Jiun , MOONEY, Jill , LUISTRO, Leopoldo
IPC: A61K39/395 , A61P16/28 , C07K16/28
CPC classification number: C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
Abstract: Provided herein are isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
Abstract translation: 本文提供了分离的CD3x PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性地 结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达提供的融合蛋白的细胞。 此外，描述了使用提供的分离的CD3 x PSMA双特异性抗原结合分子或其双特异性抗原结合片段的方法。
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公开(公告)号：WO2019224711A2
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054182
申请日：2019-05-21
Applicant: JANSSEN BIOTECH, INC.
Inventor： DIEM, Michael , GAUDET, Francois , MCDAID, Ronan , NAIR-GUPTA, Priyanka
IPC: C07K16/28
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：WO2018111976A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/065980
申请日：2017-12-13
Applicant: JANSSEN BIOTECH, INC.
Inventor： DIEM, Michael , HAWKINS, Rebecca , JACOBS, Steven , SEPULVEDA, Manuel
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：WO2017223180A3
公开(公告)日：2017-12-28
申请号：PCT/US2017/038506
申请日：2017-06-21
Applicant: JANSSEN BIOTECH, INC.
Inventor： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , GOLDBERG, Shalom , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule, isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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10.发明申请PROSTATE SPECIFIC MEMBRANE ANTIGEN BINDING FIBRONECTIN TYPE III DOMAINS 审中-公开PROSTATE特异性膜抗原结合FIBRONECTIN III型域
公开(公告)号：WO2016179534A2
公开(公告)日：2016-11-10
申请号：PCT/US2016/031295
申请日：2016-05-06
Applicant: JANSSEN BIOTECH, INC.
Inventor： CARDOSO, Rosa , DIEM, Michael , GOLDBERG, Shalom , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , O'NEIL, Karyn , SPINKA-DOMS, Tracy
IPC: C12Q1/68
CPC classification number: C07K14/78 , A61K38/00 , A61K51/08 , G01N33/57434 , G01N2333/705
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