公开(公告)号：WO2013049275A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057436

申请日：2012-09-27

Applicant: JANSSEN BIOTECH, INC. ,  DIEM, Michael ,  JACOBS, Steven

Inventor： DIEM, Michael ,  JACOBS, Steven

IPC: C40B50/00 ,  C40B40/10

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: 基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗 和疾病和病症的诊断。

公开(公告)号：WO2017223180A2

公开(公告)日：2017-12-28

申请号：PCT/US2017/038506

申请日：2017-06-21

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Mark ,  ATTAR, Ricardo ,  DIEM, Michael ,  GOLDBERG, Shalom ,  HYUN, Linus ,  JACOBS, Steven ,  KING, Alastair ,  KLEIN, Donna ,  MOORES, Sheri ,  O'NEIL, Karyn ,  PICHA, Kristen

IPC: C07K14/78

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule, isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

Abstract translation: 包含一个或多个游离半胱氨酸氨基酸的半胱氨酸改造的单特异性和双特异性EGFR和/或含c-Met FN3结构域的分子通过诱变母体分子的核酸序列并将一个或多个氨基 通过半胱氨酸编码半胱氨酸改造的含FN3结构域的单特异性或双特异性分子的酸残基; 表达半胱氨酸改造的含FN3结构域的分子; 并回收半胱氨酸改造的含FN3结构域的分子，分离的半胱氨酸改造的单特异性或双特异性FN3结构域分子可以共价连接到检测标记或药物部分上并用于治疗。

公开(公告)号：WO2018111976A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/065980

申请日：2017-12-13

Applicant: JANSSEN BIOTECH, INC.

Inventor： DIEM, Michael ,  HAWKINS, Rebecca ,  JACOBS, Steven ,  SEPULVEDA, Manuel

IPC: A61K39/00 ,  C07K16/28

Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.

公开(公告)号：WO2018111973A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/065973

申请日：2017-12-13

Applicant: JANSSEN BIOTECH, INC.

Inventor： HAWKINS, Rebecca ,  JACOBS, Steven ,  SEPULVEDA, Manuel

IPC: A61K51/08 ,  A61K49/00 ,  G01N33/53

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：WO2013177398A2

公开(公告)日：2013-11-28

申请号：PCT/US2013/042429

申请日：2013-05-23

Applicant: JANSSEN BIOTECH, INC.

Inventor： JACOBS, Steven

IPC: C07K14/00

CPC classification number: C07K14/315 ,  C07K14/001 ,  C07K14/31 ,  C07K14/47 ,  C07K2319/01 ,  C07K2319/31

Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.

Abstract translation: 非天然白蛋白结合结构域，编码其的多核苷酸以及制备和使用这些结构域和多核苷酸的方法可用于控制患者治疗分子的半衰期。

公开(公告)号：WO2017223180A3

公开(公告)日：2017-12-28

申请号：PCT/US2017/038506

申请日：2017-06-21

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Mark ,  ATTAR, Ricardo ,  DIEM, Michael ,  GOLDBERG, Shalom ,  HYUN, Linus ,  JACOBS, Steven ,  KING, Alastair ,  KLEIN, Donna ,  MOORES, Sheri ,  O'NEIL, Karyn ,  PICHA, Kristen

IPC: A61K38/00 ,  A61K38/39 ,  C07K14/78 ,  C07K16/28 ,  C12N15/09

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule, isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

公开(公告)号：WO2016179534A2

公开(公告)日：2016-11-10

申请号：PCT/US2016/031295

申请日：2016-05-06

Applicant: JANSSEN BIOTECH, INC.

Inventor： CARDOSO, Rosa ,  DIEM, Michael ,  GOLDBERG, Shalom ,  HYUN, Linus ,  JACOBS, Steven ,  KLEIN, Donna ,  O'NEIL, Karyn ,  SPINKA-DOMS, Tracy

IPC: C12Q1/68

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K51/08 ,  G01N33/57434 ,  G01N2333/705

公开(公告)号：WO2014081944A2

公开(公告)日：2014-05-30

申请号：PCT/US2013/071267

申请日：2013-11-21

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Mark ,  ATTAR, Ricardo ,  DIEM, Michael ,  HYUN, Linus ,  JACOBS, Steven ,  KING, Alastair ,  KLEIN, Donna ,  MOORES, Sheri ,  O'NEIL, Karyn ,  PICHA, Kristen

IPC: C07K14/78 ,  A61K38/39 ,  A61K45/06

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: 单特异性和双特异性EGFR和/或c-Met FN3结构域分子，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。

公开(公告)号：WO2016179518A3

公开(公告)日：2016-11-10

申请号：PCT/US2016/031260

申请日：2016-05-06

Applicant: JANSSEN BIOTECH, INC.

Inventor： ANDERSON, Glenn ,  CARDOSO, Rosa ,  DIEM, Michael ,  GAUDET, Francois ,  GOLDBERG, Shalom ,  HARMAN, Benjamin C. ,  HYUN, Linus ,  JACOBS, Steven ,  KLEIN, Donna ,  LI, Yingzhe ,  LUO, Jinquan ,  MCDAID, Ronan ,  NEMETH-SEAY, Jennifer ,  O'NEIL, Karyn ,  POMERANTZ, Steven C. ,  CHANDRA RAO, Galla ,  SPINKA-DOMS, Tracy ,  TEPLYAKOV, Alexey ,  WU, Sheng-Jiun ,  MOONEY, Jill ,  LUISTRO, Leopoldo

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/00 ,  C07K16/28

Abstract: Provided herein are isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3 x PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

公开(公告)号：WO2015057545A3

公开(公告)日：2015-04-23

申请号：PCT/US2014/060227

申请日：2014-10-13

Applicant: JANSSEN BIOTECH, INC.

Inventor： GOLDBERG, Shalom ,  JACOBS, Steven ,  LIN, Tricia ,  O'NEIL, Karyn

IPC: A61K38/22 ,  C12N1/20

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN 3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizig a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules: and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.