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公开(公告)号：WO2016180826A8
公开(公告)日：2016-11-17
申请号：PCT/EP2016/060438
申请日：2016-05-10
发明人： VAN DONGEN, Maria , BUYCK, Christophe, Francis, Robert, Nestor , SCHEPENS, Wim, Bert, Griet , JURASZEK, Jaroslaw , KESTELEYN, Bart, Rudolf, Romanie , RABOISSON, Pierre, Jean-Marie, Bernard , BRANDENBURG, Boerries
摘要： The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.
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公开(公告)号：WO2018141854A1
公开(公告)日：2018-08-09
申请号：PCT/EP2018/052537
申请日：2018-02-01
发明人： VAN DONGEN, Maria , JURASZEK, Jaroslaw , SCHEPENS, Wim, Bert, Griet , LAWSON, Edward, Charles , SHOOK, Brian, C , JONCKERS, Tim, Hugo, Maria , TAHRI, Abdellah , RABOISSON, Pierre, Jean-Marie, Bernard , BUYCK, Christophe, Francis, Robert, Nestor
IPC分类号： C07D263/57 , C07D413/14 , A61P31/16 , A61K31/496 , C07D417/04 , C07D277/66 , C07D498/04 , C07D413/12 , C07D417/12 , C07D307/81 , C07D487/08 , C07D417/10 , C07D413/10 , C07D413/04 , C07D235/18 , C07D401/10 , A61K31/4995 , A61K31/454 , A61K31/551
CPC分类号： C07D263/57 , A61P31/16 , C07D235/18 , C07D277/66 , C07D307/81 , C07D401/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12 , C07D487/08 , C07D498/04
摘要： The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
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公开(公告)号：WO2018078008A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077424
申请日：2017-10-26
摘要： The present invention relates to novel compounds, in particular peptidic macrocyclic peptides, that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses comprising HA of the H1 subtype 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic 5 compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.
摘要翻译： 本发明涉及新型化合物，特别是肽类大环肽，其能够结合和/或中和流感病毒，特别是包含H1亚型1的HA的流感A病毒，并且涉及 包含这些化合物的药物组合物 本发明还涉及拟肽化合物在诊断，预防和/或治疗流感病毒感染中的用途。
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公开(公告)号：WO2016180826A1
公开(公告)日：2016-11-17
申请号：PCT/EP2016/060438
申请日：2016-05-10
发明人： VAN DONGEN, Maria , BUYCK, Christophe, Francis, Robert, Nestor , SCHEPENS, Wim, Bert, Griet , JURASZEK, Jaroslaw , KESTELEYN, Bart, Rudolf, Romanie , RABOISSON, Pierre, Jean-Marie, Bernard , BRANDENBURG, Boerries
CPC分类号： C07K7/56 , A61K38/00 , A61P31/16 , C07K7/06 , C12N2760/16111 , G01N33/56983
摘要： The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.
摘要翻译： 本发明涉及能够结合和/或中和流感病毒，特别是系统发生性组1的甲型流感病毒的新型拟肽化合物，以及包含这些化合物的药物组合物。 本发明还涉及拟肽化合物在流感病毒感染的诊断，预防和/或治疗中的用途。
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