公开(公告)号：WO2018045199A2

公开(公告)日：2018-03-08

申请号：PCT/US2017/049668

申请日：2017-08-31

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： TOMICH, John M. ,  REECK, Gerald ,  AVILA FLORES, Luz Adriana ,  CHANDRASEKAR, Raman

IPC: A01N57/08 ,  A01N25/00

CPC classification number: A01N25/006 ,  A01N25/08 ,  A01N25/12 ,  A01N57/08 ,  A61K9/5146 ,  A61K47/6455 ,  C07K7/02 ,  C07K14/001

Abstract: Described herein are nucleic acid-peptide capsule complexes or nanoparticles comprising pre-formed peptide capsules and nucleic acids bound the exterior surface of the capsule, such that the wrap around the capsule membrane. The peptide capsules comprise bilayer membrane defining a liquid-receiving interior space and comprises a plurality of branched, amphipathic peptides. Method of making and using such complexes for delivering nucleic acids in vivo and in vitro are also described.

Abstract translation: 本文描述了核酸 - 肽胶囊复合物或纳米颗粒，其包含预先形成的肽胶囊和结合胶囊外表面的核酸，使得包裹胶囊膜。 肽胶囊包含限定液体接收内部空间并包含多个分支的两亲性肽的双层膜。 还描述了制备和使用这种用于体内和体外递送核酸的复合物的方法。