公开(公告)号：WO9922368A2

公开(公告)日：1999-05-06

申请号：PCT/IB9801599

申请日：1998-10-12

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS SVENSKA AB

Inventor： RUIGROK JACOBUS JOSEPHUS MARIA ,  COEHOORN REINDER ,  VAN DER ZAAG PIETER JAN

IPC: G01R33/09 ,  G11B5/33 ,  G11B5/39

CPC classification number: B82Y25/00 ,  G01R33/093 ,  G01R33/098 ,  G11B5/332 ,  G11B5/3903 ,  G11B5/3919 ,  G11B5/3922

Abstract: A magnetic field sensor comprising a transducer element (1), whereby: (I) the transducer element (1) is a Spin Tunnel Junction, comprising a first (1a) and second (1b) magnetic layer which are sandwiched about an interposed electrical insulator layer (1c); (II) the sensor comprises a yoke (3) having two arms (3a, 3b); (III) the first magnetic layer (1a) is in direct contact with a first portion of a first arm (3a) of the yoke (3).

Abstract translation: 1。一种包括换能器元件（1）的磁场传感器，其中：（I）所述换能器元件（1）是旋转隧道结，其包括第一（1a）和第二（1b）磁性层，所述磁性层夹在插入的电绝缘体 层（1c）; （II）传感器包括具有两个臂（3a，3b）的轭（3）; （III）第一磁性层（1a）与轭（3）的第一臂（3a）的第一部分直接接触。

公开(公告)号：WO2011027268A3

公开(公告)日：2011-06-16

申请号：PCT/IB2010053839

申请日：2010-08-26

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  VAN DER ZAAG PIETER JAN ,  FEITSMA HARMA MARTINE ,  DEN TOONDER JACOB MARINUS JAN ,  WIMBERGER-FRIEDL REINHOLD

Inventor： VAN DER ZAAG PIETER JAN ,  FEITSMA HARMA MARTINE ,  DEN TOONDER JACOB MARINUS JAN ,  WIMBERGER-FRIEDL REINHOLD

IPC: C12Q1/68

CPC classification number: C12Q1/6834 ,  C12Q2537/149 ,  C12Q2527/107

Abstract: The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.

Abstract translation: 本发明涉及用于特异性选择靶分子的装置，其包括：（a）包含微阵列的至少一个反应区，其中所述微阵列包含其上固定有一种或多种捕获分子的底物，其包含一个 或更多温度控制和/或调节单元，用于控制和/或调节该区域内的温度; （b）至少一个非反应区，包括一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）能够产生和/或调节所述反应区（a）和包括一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的至少一个输送装置。 本发明还涉及用于特异性选择靶分子的装置，其中固定的捕获分子以斑点，细长斑点和/或线的形式组织在微阵列中。 在另一方面，本发明涉及一种特异性选择靶分子的方法，包括向这种装置中引入培养基，在反应区中进行相互作用反应，将不相互作用或不结合的靶分子传输到允许重新激活 目标分子，并在反应区域与再活化的靶分子进行额外的相互作用反应，以及使用这种用于特异性选择靶分子的装置，例如 对于目标富集，文献中也称为基于微阵列的基因组选择（MGS）。

公开(公告)号：WO2012059839A3

公开(公告)日：2012-09-07

申请号：PCT/IB2011054735

申请日：2011-10-24

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  VAN DER ZAAG PIETER JAN ,  DIMITROVA NEVENKA ,  VAN DE STOLPE ANJA ,  VAN HOUTEN HENDRIK

Inventor： VAN DER ZAAG PIETER JAN ,  DIMITROVA NEVENKA ,  VAN DE STOLPE ANJA ,  VAN HOUTEN HENDRIK

IPC: G06Q10/00 ,  C12Q1/68 ,  G06F19/00

CPC classification number: G06Q20/10 ,  G06F19/18 ,  G06Q10/00 ,  G06Q50/22

Abstract: A method comprises: recording an electronic record of diagnostic events including the performing of in- vitro diagnostic tests; during the recording, identifying the performing of a licensed in- vitro diagnostic test for which license information is stored in a licenses database; and computing license compensation due to a licensor for the performing of the licensed in- vitro diagnostic test based on royalty calculation information stored in the licenses database. The recording, identifying, and computing operations are performed by one or more computers. The method may further include remitting the computed license compensation to the licensor, the remitting also being performed by one or more computers. The licensed in- vitro diagnostic test may comprise a licensed biomarker test, for example one obtained by DNA or RNA sequencing, and the method may further comprise: performing the licensed biomarker test using a genome sequencer, wherein the performing of the licensed biomarker test and the computing of license compensation are both performed at a single medical facility.

Abstract translation: 一种方法包括：记录诊断事件的电子记录，包括进行体外诊断测试; 在记录期间，识别许可证信息存储在许可证数据库中的执行的体外诊断测试的执行; 以及基于许可证数据库中存储的使用费计算信息，计算许可人对执行许可的体外诊断测试的许可证补偿。 记录，识别和计算操作由一台或多台计算机执行。 该方法可以进一步包括将计算出的许可证补偿汇出给许可人，汇款也由一个或多个计算机执行。 许可的体外诊断测试可以包括许可的生物标志物测试，例如通过DNA或RNA测序获得的测试，并且该方法可以进一步包括：使用基因组测序仪执行许可的生物标志物测试，其中执行许可的生物标志物测试和 许可证补偿的计算都是在单一的医疗机构进行的。

公开(公告)号：WO2012168803A3

公开(公告)日：2013-07-04

申请号：PCT/IB2012051920

申请日：2012-04-17

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  VAN DER ZAAG PIETER JAN ,  AMBERG RONNY ,  VERHAEGH WILHELMUS FRANCISCUS JOHANNES ,  BEYERLEIN PETER ,  BOETTCHER RENE

Inventor： VAN DER ZAAG PIETER JAN ,  AMBERG RONNY ,  VERHAEGH WILHELMUS FRANCISCUS JOHANNES ,  BEYERLEIN PETER ,  BOETTCHER RENE

IPC: G06F19/22 ,  C12Q1/68 ,  G06F19/20

CPC classification number: G06F19/22 ,  C12Q1/6874 ,  G06F19/20

Abstract: A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.

Abstract translation: 定序器装置产生包括序列发生器装置10中的捕获探针的探针数据34的基本核苷酸序列数据30以及由探针俘获的核酸片段的确定序列32。 定序器装置输出富集的核苷酸序列数据36，其富含数据，该数据包括对核酸片段预期的序列38的引用。

公开(公告)号：WO2007060591A3

公开(公告)日：2007-11-01

申请号：PCT/IB2006054330

申请日：2006-11-20

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  VAN DER ZAAG PIETER JAN ,  BAKKERS ERIK PETRUS ANTONIUS M ,  VAN DER MARK MARTINUS BERNARDU

Inventor： VAN DER ZAAG PIETER JAN ,  BAKKERS ERIK PETRUS ANTONIUS M ,  VAN DER MARK MARTINUS BERNARDU

IPC: G01N33/58

CPC classification number: G01N33/588 ,  B82Y15/00 ,  G01N33/533

Abstract: The invention provides a luminescent particle (10) and a method of detecting a biological entity using a luminescent particle, the luminescent particle comprising a core area (20) and a shell area (30), the core area (20) being covered by the shell area (30), the core area (20) conferring a luminescent behavior on the luminescent particle (10) for at least one excitation wavelength and for at least one emission wavelength by means of a nanocrystal material (21), and the shell area (30) being provided such that it realizes an antireflective coating (31) of the core area (20).

Abstract translation: 本发明提供一种发光粒子（10）和使用发光粒子检测生物实体的方法，所述发光粒子包括核心区域（20）和壳体区域（30），所述核心区域（20）由 壳体区域（30），通过纳米晶体材料（21）赋予发光粒子（10）上至少一个激发波长和至少一个发射波长的发光特性的核心区域（20），并且壳区域 （30）被设置成使得其实现所述芯部区域（20）的抗反射涂层（31）。