公开(公告)号：WO2015110436A1

公开(公告)日：2015-07-30

申请号：PCT/EP2015/051039

申请日：2015-01-21

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： DENG, Yinhui ,  LI, Xiaomin ,  GU, Xiaolin ,  SHAMDASANI, Vijay Thakur ,  WU, Ying

IPC: A61B8/08 ,  A61B8/13 ,  A61B8/14 ,  A61B8/00

CPC classification number: A61B8/523 ,  A61B8/14 ,  A61B8/145 ,  A61B8/4488 ,  A61B8/4494 ,  A61B8/465 ,  A61B8/466 ,  A61B8/469 ,  A61B8/483 ,  A61B8/54

Abstract: The present invention provides an ultrasound imaging system and an ultrasound imaging method for improving the imaging quality of the desired imaging plane in the volume of interest of a subject. According to the present invention, it is possible to directly scan the desired imaging plane by exploiting the capability of a 2D matrix ultrasound transducer and/or the flexibility of the position/orientation of the ultrasound probe. In some cases, the setting parameters of the transducer elements can be adjusted so that the ultrasound signal transmitted from the transducer elements is able to derive ultrasound echo data of the desired imaging plane without moving the probe. In other cases where the desired imaging plane cannot be directly scanned without changing the position/orientation of the ultrasound probe, the position/orientation of the ultrasound probe can be adjusted by means of user interaction, namely by outputting the instruction for guiding the user to move the probe so as to enable direct scanning of the desired imaging plane. In this way, the image of the desired imaging plane is not reconstructed by interpolation of the ultrasound echo data of the plurality of scanning planes (which are determined by the setting parameters of the transducer elements), but instead it is reconstructed from the ultrasound echo data of the desired imaging plane itself. In other words, the desired imaging plane is directly scanned. Thus, the image quality of the desired imaging plane is improved and may help doctors conduct a more accurate diagnosis.

Abstract translation: 本发明提供一种超声成像系统和超声成像方法，用于改善对象体感兴趣的所需成像平面的成像质量。 根据本发明，可以通过利用2D矩阵超声波换能器的能力和/或超声波探头的位置/取向的灵活性来直接扫描期望的成像平面。 在一些情况下，可以调节换能器元件的设定参数，使得从换能器元件发送的超声信号能够在不移动探针的情况下导出所需成像平面的超声波回波数据。 在不改变超声波探头的位置/姿势的情况下，不能直接扫描所需成像平面的其他情况下，可以通过用户交互来调整超声波探头的位置/方向，即通过输出用于引导用户的指令 移动探头，以便能够直接扫描所需的成像平面。 以这种方式，通过对多个扫描平面（由换能器元件的设定参数确定）的超声波回波数据的内插来重建所需成像平面的图像，而是从超声波回波 所需成像平面本身的数据。 换句话说，直接扫描期望的成像平面。 因此，期望的成像平面的图像质量得到改善，并且可以帮助医生进行更准确的诊断。

公开(公告)号：WO2015071815A1

公开(公告)日：2015-05-21

申请号：PCT/IB2014/065921

申请日：2014-11-10

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： DENG, Yinhui ,  LI, Xiaomin ,  GU, Xiaolin ,  SHAMDASANI, Vijay Thakur ,  WU, Ying

IPC: G06F19/18 ,  G06F19/26 ,  G06F19/00

CPC classification number: G06F19/345 ,  G06F19/00 ,  G06F19/325 ,  G16H10/60 ,  G16H50/20

Abstract: Individual computer diagnostic support (CDS) systems are coupled to a 'global' CDS system, each of the CDS systems using the same learning system or the same learning system technique. Training and testing cases from each of the individual CDS systems are provided to the global CDS system, and the global CDS system uses these training cases to produce learning system parameters based on the training cases. Having more training cases than any of the individual CDS systems, the parameters provided by the global CDS system offer a higher quality diagnostic output than any of the individual CDS systems. The learning system parameters at the global CDS system may be provided to each of the individual CDS systems, to update the parameters of the individual CDS systems' learning system. The global CDS may also refine and/or adjust the structure of the embodied learning systems.

Abstract translation: 个人计算机诊断支持（CDS）系统耦合到“全球”CDS系统，每个CDS系统使用相同的学习系统或相同的学习系统技术。 每个CDS系统的培训和测试案例均提供给全球CDS系统，全球CDS系统使用这些培训案例，根据培训案例生成学习系统参数。 具有比任何单个CDS系统更多的培训案例，由全球CDS系统提供的参数提供比任何单个CDS系统更高质量的诊断输出。 可以将全球CDS系统的学习系统参数提供给每个单独的CDS系统，以更新各个CDS系统的学习系统的参数。 全球CDS还可以改进和/或调整体现的学习系统的结构。

公开(公告)号：WO2017032715A1

公开(公告)日：2017-03-02

申请号：PCT/EP2016/069712

申请日：2016-08-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： GU, Xiaolin ,  DENG, Yinhui ,  LI, Xiaomin ,  SHAMDASANI, Vijay, Thakur ,  WU, Ying

IPC: A61B8/06 ,  A61B8/08 ,  G06F19/00

CPC classification number: A61B8/06 ,  A61B8/0825 ,  A61B8/085 ,  A61B8/481 ,  A61B8/5223 ,  G01S7/52039 ,  G06F19/00 ,  G16H30/40

Abstract: An ultrasonic diagnostic imaging system produces contrast enhanced images which are processed differently during different stages of contrast agent wash-in. During an initial stage of contrast wash-in, imaging is done using pixels processed by maximum intensity detection, to better reflect the rapid change in contrast intensity. During a later stage of contrast wash-in, time averaged processing is used to diminish the effects of noise and motion on the pixel values. During an intermediate period of peak enhancement, a combination of both pixel values processed by both techniques is used. In another aspect, a wash-in period can be characterized by an appearance stage, a growth stage and a peak stage, in which contrast pixel data is adaptively processed in different ways during these periods.

Abstract translation: 超声诊断成像系统产生对比增强图像，其在造影剂洗涤的不同阶段中被不同地处理。 在对比度洗涤的初始阶段，使用通过最大强度检测处理的像素进行成像，以更好地反映对比度强度的快速变化。 在对比度洗涤的后期阶段，使用时间平均处理来减少噪声和运动对像素值的影响。 在峰值增强的中间周期期间，使用由两种技术处理的两个像素值的组合。 在另一方面，洗涤期可以通过出现阶段，生长阶段和峰值阶段来表征，其中对比像素数据在这些周期期间以不同的方式进行自适应处理。

公开(公告)号：WO2015018946A1

公开(公告)日：2015-02-12

申请号：PCT/EP2014/067139

申请日：2014-08-11

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： DENG, Yinhui ,  LI, Xiaomin ,  GU, Xiaolin ,  SHAMDASANI, Vijay Thakur ,  WU, Ying

IPC: A61B8/00 ,  A61B8/08 ,  G06F19/00 ,  G06T7/00

CPC classification number: A61B8/5207 ,  A61B8/08 ,  A61B8/461 ,  A61B8/466 ,  A61B8/467 ,  A61B8/469 ,  A61B8/483 ,  A61B8/485 ,  A61B8/486 ,  A61B8/488 ,  A61B8/5246 ,  A61B8/5292 ,  G06F19/00 ,  G06F19/321 ,  G16H50/20

Abstract: The present invention provides a method and a system for medical imaging and information display. According to an aspect of the present invention, there is proposed a method (10) of medical imaging and information display, comprising: acquiring (11) imaging data of each point of a plurality of points in an imaging plane or imaging volume of a subject in each mode of a plurality of different imaging modes of a medical imaging apparatus; deriving (12), for said each point, a value by applying the imaging data of the point in said each mode and the imaging data of at least one other point of said plurality of points adjacent to the point in said each mode to a predetermined model, wherein the predetermined model is selected in accordance with a clinical medical application related to the subject; constructing (13) an image based on all the derived values; and displaying (14) the constructed image to a user. Accordingly, the novel method of medical imaging and information display may reduce the burden of doctors, and provide them with an image with a higher definition compared to the conventional ROI method.

Abstract translation: 本发明提供了一种用于医学成像和信息显示的方法和系统。 根据本发明的一个方面，提出了一种医学成像和信息显示的方法（10），包括：获取（11）成像平面中的多个点的每个点的数据或对象的成像体积 在医疗成像设备的多种不同成像模式的每种模式中; 通过将所述每个模式中的点的成像数据和与所述每个模式中的点相邻的所述多个点的至少另一个点的成像数据应用于预定的（12），得到（12） 模型，其中根据与所述受试者相关的临床医学应用选择所述预定模型; 构建（13）基于所有导出值的图像; 并将构造的图像显示（14）给用户。 因此，与传统的ROI方法相比，医学成像和信息显示的新颖方法可以减轻医生的负担，并为他们提供具有更高清晰度的图像。

公开(公告)号：WO2018127476A1

公开(公告)日：2018-07-12

申请号：PCT/EP2018/050030

申请日：2018-01-02

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： GU, Xiaolin ,  DENG, Yinhui ,  LI, Xiaomin ,  SHAMDASANI, Vijay, Thakur

IPC: A61B8/06 ,  A61B8/08

Abstract: An ultrasonic diagnostic imaging system and method acquire a sequence of image data as a bolus of contrast agent washes into and out of the liver. The image data of contrast intensity is used to compute time-intensity curves of contrast flow for points in an ultrasound image. Time-dependent data is calculated from the data of the time-intensity curves which, in a described implementation, comprise first and second derivatives of the time-intensity curves. A color map is formed of the time-dependent data or the polarities of the data and displayed in a parametric image as a color overlay of a contrast image of the liver.

公开(公告)号：WO2018087198A1

公开(公告)日：2018-05-17

申请号：PCT/EP2017/078690

申请日：2017-11-09

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： GU, Xiaolin ,  DENG, Yinhui ,  LI, Xiaomin ,  SHAMDASANI, Vijay Thakur

IPC: A61B8/06 ,  A61B8/08

Abstract: An ultrasonic diagnostic imaging system and method acquire a sequence of image data as a bolus of contrast agent washes into and out of the liver. The image data of contrast intensity is used to compute time-intensity curves of contrast flow in the hepatic artery, the portal vein, and at one or more regions of interest in the liver. The time-intensity curve of contrast flow in the hepatic artery is scaled to the time-intensity curve of contrast flow in a region of interest to produce time-intensity curve data representing the flow of blood at the region of interest due to arterial flow. The time-intensity curve data representing the flow of blood at the region of interest due to arterial flow is subtracted from the time-intensity curve of contrast flow in the region of interest to produce time-intensity curve data representing the flow of blood at the region of interest due to venous flow.

Abstract translation: 超声诊断成像系统和方法获取一系列图像数据，作为造影剂大量进出肝脏的造影剂。 对比强度的图像数据用于计算肝动脉，门静脉和肝脏中一个或多个感兴趣区域的造影剂流动的时间 - 强度曲线。 将肝动脉中造影剂流动的时间 - 强度曲线缩放为感兴趣区域中造影剂流动的时间 - 强度曲线，以产生代表由于动脉血流引起的感兴趣区域处的血液流动的时间 - 强度曲线数据。 从感兴趣区域中的对比度流的时间强度曲线中减去表示由于动脉流动引起的感兴趣区域处的血液流量的时间强度曲线数据，以产生时间强度曲线数据，该时间强度曲线数据表示血液在 感兴趣的区域由于静脉流动。

公开(公告)号：WO2016097320A1

公开(公告)日：2016-06-23

申请号：PCT/EP2015/080552

申请日：2015-12-18

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： GU, Xiaolin ,  SHAMDASANI, Vijay Thakur ,  DENG, Yinhui ,  LI, Xiaomin ,  WU, Ying

IPC: A61B8/08 ,  A61B8/00

CPC classification number: A61B8/481 ,  A61B8/085 ,  A61B8/463 ,  A61B8/483 ,  A61B8/5223

Abstract: The present invention proposes an ultrasound imaging system and a method of calculating a perfusion parameter ratio. The proposed approach comprises: acquiring a time intensity curve of a contrast agent for each region unit of a plurality of region units of an imaging region of a subject, each region unit comprising one or more points of the imaging region; selecting, among the plurality of region units, a first, second and third sets of region units respectively corresponding to normal tissue, vessel and background noise, based on the time-intensity curves; calculating a perfusion parameter for each of one or more region units of the first set of region units and a perfusion parameter for a region of interest in the imaging region based on the calculated time-intensity curves; calculating a reference perfusion parameter based on the perfusion parameters of the one or more region units; and calculating a ratio value for the region of interest as a ratio of the perfusion parameter of the region of interest and the reference perfusion parameter. Since the reference perfusion parameter is calculated based on the one or more region units which are automatically selected, the approach requires no manual manipulation and the calculated perfusion parameter ratios are independent of operator experience.

Abstract translation: 本发明提出一种超声成像系统和计算灌注参数比的方法。 所提出的方法包括：获取对象成像区域的多个区域单元中的每个区域单元的造影剂的时间强度曲线，每个区域单元包括成像区域的一个或多个点; 基于时间 - 强度曲线，在多个区域单元中选择分别对应于正常组织，血管和背景噪声的第一，第二和第三组区域单位; 基于所计算的时间 - 强度曲线，计算所述第一组区域单位的一个或多个区域单元中的每一个的灌注参数和所述成像区域中的感兴趣区域的灌注参数; 基于一个或多个区域单元的灌注参数计算参考灌注参数; 以及计算感兴趣区域的比值作为感兴趣区域的灌注参数与参考灌注参数的比值。 由于基于自动选择的一个或多个区域单位计算参考灌注参数，所以该方法不需要手动操作，并且所计算的灌注参数比率与操作者体验无关。