专利检索 ap:("LATVIAN INSTITUTE OF ORGANIC SYNTHESIS") AND inv:"JIRGENSONS, Aigars" 第 1 页

1.

发明申请
MACROCYCLIC AMIDES ACTING AS PLASMEPSIN INHBITORS FOR THE TREATMENT OF MALARIA 审中-公开

公开(公告)号：WO2021123883A1

公开(公告)日：2021-06-24

申请号：PCT/IB2019/061066

申请日：2019-12-19

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： JIRGENSONS, Aigars , KOVADA, Vadims , BOBROVS, Raitis , SUNA, Edgars , JAUDZEMS, Kristaps , RASINA, Dace , ZOGOTA, Rimants

IPC分类号： A61P33/06 , A61K31/33 , C07D498/08

摘要： The present invention relates to medicine and in particular to the treatment of malarial infections, more particularly to inhibitors of malarial aspartic proteases - plasmepsins. Even more particularly, the invention relates to macrocyclic amides and pharmaceutical compositions thereof and their use as inhibitors for plasmepsins (Plm).

2.

发明申请
NOVEL SUBSTITUTED 2-AMINOQUINAZOLIN-4(3H)-ONE DERIVATIVES AS MALARIAL ASPARTIC PROTEASE INHIBITORS 审中-公开
标题翻译：新的替代的2-氨基喹啉-4（3H） - 酮衍生物作为疟原虫蛋白酶抑制剂

公开(公告)号：WO2015063544A1

公开(公告)日：2015-05-07

申请号：PCT/IB2013/059782

申请日：2013-10-30

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： JIRGENSONS, Aigars , DOMRACEVA, Ilona , KANEPE-LAPSA, Iveta , RASINA, Dace , JAUDZEMS, Kristaps , OTIKOVS, Martins

IPC分类号： C07D405/04 , A61K31/505 , A61P33/06

CPC分类号： C07D405/04

摘要： The present invention discloses novel substituted 2-aminoquinazolin-4(3H)-one derivatives and their use as inhibitors of malarial aspartic protease plasmepsin I,II,IV or related malarial aspartic proteases, as well as pharmaceutical compositions thereof for treatment of malaria.

摘要翻译： 本发明公开了新型取代的2-氨基喹唑啉-4（3H） - 酮衍生物及其作为疟疾天冬氨酸蛋白酶等离子体蛋白酶I，II，IV或相关疟疾天冬氨酸蛋白酶抑制剂的用途，以及用于治疗疟疾的药物组合物。

3.

发明申请
NOVEL ADENOSYLMERCAPTANE DERIVATIVES AS VIRAL mRNA CAP METHYLTRANSFERASE INHIBITORS 审中-公开

公开(公告)号：WO2022189846A1

公开(公告)日：2022-09-15

申请号：PCT/IB2021/061623

申请日：2021-12-13

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： BOBILEVA, Olga , BOBROVS, Raitis , KANEPE, Iveta , KALNINS, Gints , SISOVS, Mihails , BULA, Anna Lina , JIRGENSONS, Aigars , TARS, Kaspars , JAUDZEMS, Kristaps

IPC分类号： A61K31/14 , A61K31/52 , C07H19/167

摘要： The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylmercaptane derivatives and pharmaceutical compositions thereof and their use as inhibitors for viral mRNA cap methyltransferases.

4.

发明申请
NOVEL BORONIC ACID CONTAINING PEPTIDOMIMETICS AS MALARIAL SERINE PROTEASE INHIBITORS 审中-公开

公开(公告)号：WO2021001697A1

公开(公告)日：2021-01-07

申请号：PCT/IB2020/053392

申请日：2020-04-09

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： JIRGENSONS, Aigars , LIDUMNIECE, Elina , WITHERS-MARTINEZ, Chrislaine , BLACKMAN, Michael , FINN, Paul William

IPC分类号： A61P33/06 , A61K38/55

摘要： The invention relates to novel boric acid-containing peptidomimetics I, (I) acting as inhibitors of the malaria subtilisin-related serine protease (SUB). They are useful as medicinal preparations or as ingredients for the treatment of malaria.

5.

发明申请
SUBSTITUTED AMINOALKYLAZOLES AS MALARIAL ASPARTIC PROTEASE INHIBITORS 审中-公开
标题翻译：作为疟原虫蛋白酶抑制剂的取代氨基喹唑啉

公开(公告)号：WO2017069601A1

公开(公告)日：2017-04-27

申请号：PCT/LV2015/000007

申请日：2015-10-19

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： KINENA, Linda , OZOLA, Vita , SUNA, Edgars , LEITIS, Gundars , JIRGENSONS, Aigars , JAUDZEMS, Kristaps , KANEPE-LAPSA, Iveta , DOMRACHEVA, Ilona

IPC分类号： C07D401/06 , C07D401/10 , C07D401/12 , C07D413/10 , C07D249/06 , C07D261/08 , C07D207/08 , C07D207/20 , C07D207/333 , A61K31/4192 , A61P33/06

CPC分类号： C07D401/10 , C07D207/08 , C07D207/20 , C07D207/333 , C07D249/06 , C07D261/08 , C07D401/06 , C07D401/12 , C07D413/10

摘要： The present invention relates to novel aminoalkylazoles acting as inhibitors of malarial protease plasmepsin II. These can be used as medicines or as constituent of medicines for the treatment of malaria infection.

摘要翻译： 本发明涉及作为疟疾蛋白酶plasmepsin II抑制剂的新型氨基烷基唑类。这些可以用作药物或作为治疗疟疾感染的药物成分。

6.

发明申请
NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS 审中-公开
标题翻译：新型N-亚氨基磺酰胺衍生物作为氨基酰基-TNA合成酶抑制剂

公开(公告)号：WO2016129983A1

公开(公告)日：2016-08-18

申请号：PCT/LV2016/000001

申请日：2016-02-11

申请人： LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人： JIRGENSONS, Aigars , LOZA, Einars , CHARLTON, Michael , FINN, Paul William , RIBAS DE POUPLANA, Lluis , SAINT-LEGER, Adelaide

IPC分类号： C07D213/71 , C07D311/20 , C07D215/36 , C07D217/22 , C07C311/00 , C07D239/42 , C07D239/47 , C07D239/48 , C07D251/22 , C07D487/04 , A61K31/4402 , A61K31/47 , A61K31/505 , A61K31/18 , A61P31/00

CPC分类号： C07C311/51 , C07C2601/02 , C07D213/71 , C07D215/06 , C07D215/36 , C07D217/04 , C07D217/22 , C07D217/26 , C07D239/42 , C07D239/47 , C07D239/48 , C07D251/22 , C07D311/04 , C07D311/20 , C07D487/04

摘要： The present invention relates to novel N-acyl-diarysulfonamides acting as inhibitors of bacterial aminoacyl-tRNA synthetase. These can be used as medicines or as constituent of medicines for the treatment of bacterial infections.

摘要翻译： 本发明涉及作为细菌氨酰-tRNA合成酶抑制剂的新型N-酰基 - 二芳基磺酰胺。这些可用作药物或用作治疗细菌感染的药物的组成部分。