公开(公告)号：WO2018070938A1

公开(公告)日：2018-04-19

申请号：PCT/SG2017/050512

申请日：2017-10-12

申请人： LIFE TECHNOLOGIES HOLDINGS PTE LIMITED

发明人： CHEN, Mingsong ,  SHI, Benyong ,  TOH, Tiong Han ,  YEO, Steven

IPC分类号： G02B21/06 ,  G02B21/36 ,  G01N21/64

CPC分类号： G02B27/14 ,  G01N21/253 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G02B6/04 ,  G02B17/02 ,  G02B21/06 ,  G02B21/362 ,  G02B26/0816 ,  G02B27/1066 ,  G02B27/108 ,  G02B27/16

摘要： An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.

摘要翻译： 照明系统包括被配置为具有放置在其上的成像目标的表面，光源，分束器和至少第一反射镜。 分束器被配置为分离来自光源的光束，并且第一反射镜被配置为将来自分束器的第一光束反射到具有成像目标的表面上。 成像系统包括被配置成具有放置在其上的成像目标的成像表面，镜子和捕捉装置。 捕捉设备被配置为通过从成像目标延伸的发射光的路径捕捉成像目标的图像，从镜子反射并捕捉到捕捉设备。 镜子，捕捉设备或两者被配置成相对于成像表面沿对角方向移动以减小发射光路径的长度。 校准成像系统以消除或减少由于成像系统特性导致的样品图像内的不均匀性的系统和方法。