公开(公告)号：WO2019020726A1

公开(公告)日：2019-01-31

申请号：PCT/EP2018/070242

申请日：2018-07-26

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  ZARAGOZA DOERWALD, Florencio ,  ELLINGER, Stefan ,  BELLER, Matthias ,  NEUMANN, Helfried ,  WENIGER, Florian

IPC: C07B37/04 ,  C07D231/12 ,  C07D333/12 ,  C07D233/64 ,  C07D241/10 ,  C07D207/33 ,  C07D213/26 ,  C07C43/17 ,  C07C43/225 ,  C07C41/30 ,  C07C45/68

Abstract: The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.

公开(公告)号：WO2016071425A1

公开(公告)日：2016-05-12

申请号：PCT/EP2015/075763

申请日：2015-11-05

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  ZARAGOZA DOERWALD, Florencio ,  ELLINGER, Stefan ,  BELLER, Matthias ,  NEUMANN, Helfried ,  HE, Lin ,  NATTE, Kishore

IPC: C07B39/00 ,  C07C17/275 ,  C07C22/08 ,  C07C41/30 ,  C07C43/225 ,  C07C45/69 ,  C07C49/80 ,  C07D207/325 ,  C07D207/333 ,  C07D209/10 ,  C07D333/12 ,  C07D473/08 ,  C07D473/10

CPC classification number: C07D473/10 ,  C07B39/00 ,  C07C17/272 ,  C07C17/275 ,  C07C22/08 ,  C07C41/30 ,  C07C43/225 ,  C07C45/68 ,  C07C45/69 ,  C07C49/80 ,  C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D209/10 ,  C07D333/12 ,  C07D473/08 ,  C07C49/84

Abstract: The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl.

Abstract translation: 本发明公开了一种在二（1-金刚烷基） - 丁基膦存在下通过氟，氯和氟氯烷基卤化物均相Pd催化的氟，氯和氟氯烷基化制备氟，氯和氟氯烷基化合物的方法， 的2,2,6,6-四甲基哌啶1-氧基。

公开(公告)号：WO2020169770A1

公开(公告)日：2020-08-27

申请号：PCT/EP2020/054546

申请日：2020-02-20

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  BELSER, Thomas ,  ELLINGER, Stefan ,  ZARAGOZA DOERWALD, Florencio ,  BELLER, Matthias ,  NEUMANN, Helfried ,  FISCHER, Florian ,  ZHANG, Shaoke

IPC: C07D319/12 ,  C07F15/04 ,  C07F17/00

Abstract: The invention discloses a method for the preparation of fluoro alkylated 1,4-dioxene by homogene- ous Ni catalyzed fluoro alkylation with fluoro alkyl halides of 1,4-dioxane in the presence of a base.

公开(公告)号：WO2020249759A1

公开(公告)日：2020-12-17

申请号：PCT/EP2020/066351

申请日：2020-06-12

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  BELLER, Matthias ,  NEUMANN, Helfried ,  FISCHER, Florian ,  ZHANG, Shaoke ,  YE, Fei ,  ELLINGER, Stefan ,  ZARAGOZA DOERWALD, Florencio

IPC: C07D207/06 ,  C07D211/12 ,  C07D223/04 ,  C07D265/30 ,  C07D317/72

Abstract: The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

公开(公告)号：WO2020169768A1

公开(公告)日：2020-08-27

申请号：PCT/EP2020/054542

申请日：2020-02-20

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  ELLINGER, Stefan ,  ZARAGOZA DOERWALD, Florencio ,  BELLER, Matthias ,  NEUMANN, Helfried ,  FISCHER, Florian ,  ZHANG, Shaoke ,  ROTTA-LORIA, Nicolas

IPC: C07F15/04 ,  C07F17/00 ,  C07D319/12 ,  C07C17/00 ,  C07D333/12 ,  C07D233/10 ,  C07D213/62

Abstract: The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base.

公开(公告)号：WO2015185677A1

公开(公告)日：2015-12-10

申请号：PCT/EP2015/062474

申请日：2015-06-04

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  BELLER, Matthias ,  NEUMANN, Helfried ,  HE, Lin ,  NATTE, Kishore ,  ELLINGER, Stefan ,  ZARAGOZA DOERWALD, Florencio

IPC: C07D333/12 ,  C07D333/28 ,  C07B37/04 ,  C07D473/12 ,  C07D207/323 ,  C07D213/127 ,  C07D213/26 ,  C07C17/32 ,  C07C22/08 ,  C08F8/24

CPC classification number: C07D473/12 ,  C07B37/04 ,  C07C17/32 ,  C07C22/08 ,  C07C41/30 ,  C07C45/68 ,  C07C253/30 ,  C07D207/323 ,  C07D213/127 ,  C07D213/26 ,  C07D333/12 ,  C07D333/28 ,  C08F8/24 ,  C07C25/02 ,  C07C255/54 ,  C07C43/225 ,  C07C43/23 ,  C07C49/84 ,  C08F12/08

Abstract: The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs 2 C0 3 or CsHC0 3 .

Abstract translation: 本发明公开了在Cs 2 CO 3存在下，用烷基卤化物或氟，氯和氟氯代烷基卤化物进行异构Pt / C催化烷基化或氟，氯和氟氯烷基化制备烷基化或氟，氯和氟氯烷基化合物的方法 或CsHC03。