公开(公告)号：WO2022045959A1

公开(公告)日：2022-03-03

申请号：PCT/SG2020/050492

申请日：2020-08-22

Applicant: SUI, Jianjun

Inventor： SUI, Jianjun

IPC: C07D319/12

Abstract: This invention relates to a process by means of distillation for the purification of lactide from a crude lactide vapor product stream, which crude lactide is produced by depolymerization of low molecular weight polylactic acid and is composed of at least water, lactic acid, lactide and lactic acid oligomers, wherein a divided wall column is used as one of the distillation stages to obtain a purified liquid lactide product stream as the sidedraw of the said divided wall column.

公开(公告)号：WO2021083209A1

公开(公告)日：2021-05-06

申请号：PCT/CN2020/124381

申请日：2020-10-28

Applicant: ECCOGENE (SHANGHAI) CO., LTD.

Inventor： REN, Zaifang ,  SUN, Xuefeng ,  XU, Qing

IPC: C07D309/04 ,  C07D319/12 ,  C07D309/10 ,  C07D309/08 ,  C07C317/14 ,  C07D307/10 ,  C07D309/12 ,  C07D211/46 ,  C07D309/06 ,  C07D205/04 ,  C07D275/02 ,  C07D207/06 ,  C07D401/04 ,  C07D295/08 ,  A61K31/10 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00

Abstract: Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of formula (I') or (I), and a method of treating or preventing a disease in which SSAO plays a role.

公开(公告)号：WO2021055849A1

公开(公告)日：2021-03-25

申请号：PCT/US2020/051629

申请日：2020-09-18

Applicant: MODERNATX, INC.

Inventor： BENENATO, Kerry E. ,  CORNEBISE, Mark ,  HENNESSY, Edward ,  MCKENZIE, Andrew

IPC: C07C311/05 ,  C07C311/10 ,  C07C311/11 ,  C07C311/13 ,  C07C311/14 ,  C07C311/24 ,  C07D231/18 ,  C07D233/84 ,  C07D239/38 ,  C07D213/61 ,  C07D261/08 ,  C07D285/10 ,  C07D305/06 ,  C07D305/08 ,  C07D307/18 ,  C07D309/08 ,  C07D319/12 ,  C07D333/48 ,  A61K9/51 ,  A61K9/127 ,  A61K47/06 ,  A61K47/24

Abstract: The application relates to lipids of Formula (A-1) and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include such a lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/ or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：WO2020087217A1

公开(公告)日：2020-05-07

申请号：PCT/CN2018/112468

申请日：2018-10-29

Applicant: PUJING CHEMICAL INDUSTRY CO., LTD

Inventor： LIU, Wei

IPC: C07D319/12 ,  C08G63/06

Abstract: The invention relates to a process of preparing a glycolide product from methyl polyglycolate or its product. The process comprises depolymerizing the methyl polyglycolate or its product in the presence of a depolymerization agent to make a depolymerized product; repolymerizing the depolymerized product to make a glycolic acid oligomer; and pyrolyzing the repolymerized mixture to make a glycolide product. A rare earth metal catalyst may be used facilitate the depolymerization reaction. The glycolide pyrolysis conversion rate may be greater than 90%. Also provided are related glycolide product and the glycolic acid oligomer. The glycolic acid oligomer may have a weight average molecular weight of 4, 000-80, 000.

公开(公告)号：WO2019032126A1

公开(公告)日：2019-02-14

申请号：PCT/US2017/047114

申请日：2017-08-16

Applicant: NOVUS INTERNATIONAL INC.

Inventor： WANG, Xiaojun ,  HOCHWALT, Mark A. ,  ARHANCET, Graciela B.

IPC: C07C67/00 ,  C07C67/08 ,  C07D319/10 ,  C07D319/12

CPC classification number: C07D319/12

Abstract: Processes for preparing heteroatom containing cyclic dimers that result in increased production efficiency and reduced waste production.

公开(公告)号：WO2018088182A1

公开(公告)日：2018-05-17

申请号：PCT/JP2017/038174

申请日：2017-10-23

Applicant: 東洋製罐株式会社

Inventor： 伊藤　卓郎

IPC: C07D319/12 ,  C08J11/12

CPC classification number: C07D319/12 ,  C08G63/91 ,  C08J11/12 ,  C08J11/16 ,  Y02W30/703 ,  Y02W30/705

Abstract: ラクチドを含む樹脂混合物を減圧下に保持し、該樹脂混合物中に含まれるラクチドをガス化し、ガス状ラクチドを含むガス混合物を真空引きしながら、凝縮ラインＡに導入してラクチドを回収する方法において、前記凝縮ラインＡは、冷却温度が順次低くなるように、複数の凝縮器７１、７３、７５が直列に配列しており、これらの凝縮器によって前記ガス混合物から、ラクチドの捕集及びラクチド以外の不純物の分離を行うことを特徴とする。

Abstract translation: 含

树脂混合物交酯保持在减压下，丙交酯中含有的树脂混合物气化，而抽真空的气体混合物，其包含的气态丙交酯，引入缩合线A 在冷凝管线A中，多个冷凝器71,73,75串联布置，使得冷却温度顺序降低，并且这些冷凝器用于从气体混合物中回收丙交酯 ，收集丙交酯并分离丙交酯以外的杂质。

公开(公告)号：WO2018055170A1

公开(公告)日：2018-03-29

申请号：PCT/EP2017/074247

申请日：2017-09-25

Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN

Inventor： DE CLERCQ, Rik ,  DUSSELIER, Michiel ,  SELS, Bert

IPC: C07D319/12

Abstract: The invention relates to a process for preparing cyclic esters by means of a transesterification reaction in the gas phase, comprising the steps of: (i) vaporizing a liquid solution of alpha-hydroxy esters, (ii) passing the ester vapors through a reaction zone containing a solid catalyst and (iii) recovering the cyclic esters from the gaseous product stream; and wherein the solid catalyst comprises at least one metal of titanium (Ti) and Zirconium (Zr), and a SiO 2 support, and wherein said metal is chemically bound to the SiO 2 support through M-O-Si chemical bonds.

Abstract translation: 本发明涉及通过气相中的酯基转移反应制备环酯的方法，其包括以下步骤：（i）蒸发α-羟基酯的液体溶液，（ii） 使酯蒸气通过含有固体催化剂的反应区，和（iii）从气态产物流中回收环酯; 并且其中所述固体催化剂包含钛（Ti）和锆（Zr）中的至少一种金属和SiO 2载体，并且其中所述金属化学键合至SiO 2 / 通过MO-Si化学键进行支撑。

公开(公告)号：WO2016183053A1

公开(公告)日：2016-11-17

申请号：PCT/US2016/031593

申请日：2016-05-10

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： HUMPHREY, Simon, M. ,  HOLLIDAY, Bradley, J. ,  MOORE, Matthew, D. ,  DUNNING, Samuel, G.

IPC: C07D319/12 ,  C09K11/07 ,  C09K11/08 ,  G01N21/64

CPC classification number: G01N21/78 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/182 ,  G01N31/22 ,  G01N2021/7786

Abstract: Embodiments of the present disclosure pertain to methods of monitoring an environment for the presence of a solvent by: (i) exposing the environment to a luminescent compound, where the relative luminescence emission intensity of the luminescent compound changes upon interaction with the solvent; and (ii) monitoring a change in the relative luminescence emission intensity of the luminescent compound, where the absence of the change indicates the absence of the solvent from the environment, and where the presence of the change indicates the presence of the solvent in the environment. The luminescent compounds include a phosphorous atom with one or more carboxyl groups, where the carboxyl groups are coordinated with one or more metallic ions (e.g., lanthanide ions and yttrium ions). The present disclosure also pertains to sensors for monitoring an environment for the presence of a solvent, where the sensors include one or more of the aforementioned luminescent compounds.

Abstract translation: 本公开的实施方案涉及通过以下方式监测溶剂存在的环境的方法：（i）将环境暴露于发光化合物，其中发光化合物的相对发光强度随溶剂相互作用而改变; 和（ii）监测发光化合物的相对发光强度的变化，其中不存在变化表明溶剂不存在于环境中，并且如果存在变化表明溶剂在环境中的存在 。 发光化合物包括具有一个或多个羧基的磷原子，其中羧基与一种或多种金属离子（例如镧系元素离子和钇离子）配位。 本公开还涉及用于监测溶剂存在的环境的传感器，其中传感器包括一种或多种上述发光化合物。

公开(公告)号：WO2016174161A1

公开(公告)日：2016-11-03

申请号：PCT/EP2016/059539

申请日：2016-04-28

Applicant: PURAC BIOCHEM BV

Inventor： DE VRIES, Johannes Jeichienus ,  CAVACO MORAO, Ana Isabel ,  DE HAAN, Andre Banier

IPC: C07D319/12

CPC classification number: C07D319/12 ,  B01D3/34 ,  B01D3/42 ,  B01J19/0013 ,  B01J19/0066 ,  B01J2219/00033 ,  B01J2219/00051 ,  B01J2219/00166

Abstract: The invention relates to a method and a device for manufacturing lactide, whereby crude lactide, being prepared by means of depolymerization of lactic acid oligomers, is purified by means of a distillation step. According to the invention, the prepared crude lactide is maintained for a period of at least 5 hours in a reaction vessel at a temperature between 97º C and 200º C prior to the distillation step. Keeping the lactide during a period of time in a reaction vessel leads to a decrease of the lactic acid content and an increase of the lactic acid oligomer concentration, so that the resulting crude lactide can be more efficiently purified during subsequent distillation. A pre-distilling step gives additional advantages.

Abstract translation: 本发明涉及一种制造丙交酯的方法和装置，其中通过乳酸低聚物的解聚制备的粗丙交酯通过蒸馏步骤纯化。 根据本发明，在蒸馏步骤之前，将制备的粗丙交酯在反应容器中在97℃至200℃之间的温度下保持至少5小时。 在一段时间内将丙交酯在反应容器中保持导致乳酸含量的降低和乳酸低聚物浓度的增加，使得得到的粗丙交酯可以在随后的蒸馏中更有效地纯化。 预蒸馏步骤提供了额外的优点。

公开(公告)号：WO2016097750A1

公开(公告)日：2016-06-23

申请号：PCT/GB2015/054065

申请日：2015-12-18

Applicant: PLAXICA LIMITED

Inventor： PANDYA, Urvish Rameschchandra

IPC: B01D61/44 ,  C07C51/41 ,  C07C51/47 ,  C07C59/08 ,  C07C67/08 ,  C07C69/68 ,  C07D319/12 ,  C07C29/149 ,  C07C57/065

CPC classification number: C07C51/41 ,  B01D61/44 ,  B01D61/445 ,  C07C51/47 ,  C07C59/08

Abstract: A process for the production of lactic acid comprising: (a) reacting a stream rich in saccharide with sodium hydroxide in the presence of water to produce a reaction mixture comprising sodium lactate; and (b) subjecting at least part of said reaction mixture to electrodialysis using an electrodialysis cell containing a cation-selective membrane to produce a first product stream comprising lactic acid and a second product stream comprising sodium hydroxide.

Abstract translation: 一种生产乳酸的方法，包括：（a）在水存在下使富含糖的物流与氢氧化钠反应，以产生包含乳酸钠的反应混合物; 和（b）使用含有阳离子选择性膜的电渗析池对所述反应混合物的至少一部分进行电渗析，以产生包含乳酸的第一产物流和包含氢氧化钠的第二产物流。