公开(公告)号：WO2020169770A1

公开(公告)日：2020-08-27

申请号：PCT/EP2020/054546

申请日：2020-02-20

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  BELSER, Thomas ,  ELLINGER, Stefan ,  ZARAGOZA DOERWALD, Florencio ,  BELLER, Matthias ,  NEUMANN, Helfried ,  FISCHER, Florian ,  ZHANG, Shaoke

IPC: C07D319/12 ,  C07F15/04 ,  C07F17/00

Abstract: The invention discloses a method for the preparation of fluoro alkylated 1,4-dioxene by homogene- ous Ni catalyzed fluoro alkylation with fluoro alkyl halides of 1,4-dioxane in the presence of a base.

公开(公告)号：WO2015067405A1

公开(公告)日：2015-05-14

申请号：PCT/EP2014/070233

申请日：2014-09-23

Applicant: LONZA LTD

Inventor： SIEVERT, Katharina ,  SCHULZ, Axel ,  HARLOFF, Jörg ,  ELLINGER, Stefan ,  TAESCHLER, Christoph ,  ZUR TAESCHLER, Cornelia

IPC: H01M10/056 ,  C07F5/02 ,  C07F5/00 ,  C07F5/06 ,  H01M6/14 ,  H01L31/00 ,  H01M14/00

CPC classification number: C07F5/027 ,  B01J27/125 ,  B01J29/7049 ,  B01J31/0287 ,  C07C209/68 ,  C07D233/58 ,  H01M6/14 ,  H01M10/056 ,  H01M14/005 ,  H01M2300/0022

Abstract: The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Cat n+ ][(Z 1 F 4-m (CN) m ) - ] n by a reaction of [(Z 1 F 4 ) - ] with trimethylsilylcyanide in the presence of a Lewis acid and in the presence of the cation Cat n+ ; Cat n+ is a cation, Z 1 is B, Al, Ga, In or Tl, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4.

Abstract translation: 本发明公开了一种由式（I）代表的具有1,2,3或4个氰基的周期表第13族的氰基化合物的制备方法：[Catn +] [（Z1F4-m（CN）m） - ]在路易斯酸存在下和在阳离子Catn +存在下，通过[（Z1F4） - ]与三甲基甲硅烷基氰化物的反应， Catn +是阳离子，Z1是B，Al，Ga，In或Tl，m是1,2,3或4，n是1,2,3或4。

公开(公告)号：WO2018154097A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054620

申请日：2018-02-26

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  GIRARD, Christophe ,  TONAZZI, Sandro ,  POLENSKE, Daniel ,  GARMS, Stefan ,  ESCHER, Christoph ,  LORENZ, Andreas ,  BINER, Sonja ,  VON DER GRUEN, Mareile ,  KUEHBERGER, Herbert ,  ZURBRIGGEN, Jonas ,  IN-ALBON, Dieter ,  LUTZ, Beat

IPC: C07D231/34

CPC classification number: C07D231/34

Abstract: The invention discloses a method for the preparation of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol with high selectivity with respect to the content of the isomer 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol, wherein ethyl 4,4,4-trifluoroacetoacetate is reacted with methyl hydrazine in the presence of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol: ethyl 4,4,4-trifluoroacetoacetate and methyl hydrazine are brought into contact in the presence of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol and are reacted in the presence of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol.

公开(公告)号：WO2016023929A1

公开(公告)日：2016-02-18

申请号：PCT/EP2015/068508

申请日：2015-08-12

Applicant: LONZA LTD

Inventor： ZARAGOZA DOERWALD, Florencio ,  TAESCHLER, Christoph ,  HATTORI, Hiromu

IPC: C07C51/09 ,  C07C51/44 ,  C07C59/21

CPC classification number: C07C51/09 ,  C07C51/44 ,  C07C59/21

Abstract: The invention discloses a method for the preparation of trifluoroacetylacetic acid in its dehydrated form with a low content of the hydrate of trifluoroacetoacetic acid.

Abstract translation: 本发明公开了一种三乙酰乙酸水合物含量低的脱水形式的三氟乙酰乙酸的制备方法。

公开(公告)号：WO2019020726A1

公开(公告)日：2019-01-31

申请号：PCT/EP2018/070242

申请日：2018-07-26

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  ZARAGOZA DOERWALD, Florencio ,  ELLINGER, Stefan ,  BELLER, Matthias ,  NEUMANN, Helfried ,  WENIGER, Florian

IPC: C07B37/04 ,  C07D231/12 ,  C07D333/12 ,  C07D233/64 ,  C07D241/10 ,  C07D207/33 ,  C07D213/26 ,  C07C43/17 ,  C07C43/225 ,  C07C41/30 ,  C07C45/68

Abstract: The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.

公开(公告)号：WO2016071425A1

公开(公告)日：2016-05-12

申请号：PCT/EP2015/075763

申请日：2015-11-05

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  ZARAGOZA DOERWALD, Florencio ,  ELLINGER, Stefan ,  BELLER, Matthias ,  NEUMANN, Helfried ,  HE, Lin ,  NATTE, Kishore

IPC: C07B39/00 ,  C07C17/275 ,  C07C22/08 ,  C07C41/30 ,  C07C43/225 ,  C07C45/69 ,  C07C49/80 ,  C07D207/325 ,  C07D207/333 ,  C07D209/10 ,  C07D333/12 ,  C07D473/08 ,  C07D473/10

CPC classification number: C07D473/10 ,  C07B39/00 ,  C07C17/272 ,  C07C17/275 ,  C07C22/08 ,  C07C41/30 ,  C07C43/225 ,  C07C45/68 ,  C07C45/69 ,  C07C49/80 ,  C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D209/10 ,  C07D333/12 ,  C07D473/08 ,  C07C49/84

Abstract: The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl.

Abstract translation: 本发明公开了一种在二（1-金刚烷基） - 丁基膦存在下通过氟，氯和氟氯烷基卤化物均相Pd催化的氟，氯和氟氯烷基化制备氟，氯和氟氯烷基化合物的方法， 的2,2,6,6-四甲基哌啶1-氧基。

公开(公告)号：WO2014167035A1

公开(公告)日：2014-10-16

申请号：PCT/EP2014/057220

申请日：2014-04-10

Applicant: LONZA LTD

Inventor： SIEVERT, Katharina ,  SCHULZ, Axel ,  HARLOFF, Jörg ,  STOFFERS, Alrik ,  ELLINGER, Stefan ,  OTT, Lothar ,  RIJKSEN, Christiaan ,  FRANKE, Patrick ,  TAESCHLER, Christoph ,  ZUR TAESCHLER, Cornelia

IPC: C07F9/02 ,  C09K19/00 ,  H01M10/0568 ,  C01B25/10

CPC classification number: H01M10/0569 ,  C07F9/02 ,  H01M10/0568 ,  H01M2300/0045

Abstract: The invention discloses a method for preparation of fluoro and chloro cyano compounds represented by formula (I) given below, by a reactions using trimethylsilylcyanide. The compounds are used as ionic liquids in electrochemical or optoelectronic devices such as batteries and solar cells. [Cat n+ ] [(Z 1 (Q 1 ) 6-m (CN) m ) - ] n (I) Also disclosed are electrolyte formulations and compounds of a subgroup of formula (I), represented by formula (la). [Cat n+ ] [(cis-PF 2 (CN) 4 ) ] n (la) Typical examples of formula (lb) are: [(n-Bu)4N] [cis-PF2(CN)4], Ag[cis-PF 2 (CN) 4 ], K[cis-PF 2 (CN) 4 ], Li[cis- PF 2 (CN) 4 ], [Et 3 HN][ [cis-PF 2 (CN) 4 ], [(n-Bu) 4 P][cis-PF 2 (CN) 4 ], [H30] [cis-PF2(CN)4], Mg[cis-PF 2 (CN) 4]2 *4H 2 0, Zn[cis-PF 2 (CN) 4]2 *2H 2 0, [H 5 0 2 ] [Cis-PF 2 (CN) 4 ]

Abstract translation: 本发明公开了通过使用三甲基甲硅烷基氰的反应制备由下式（I）表示的氟代和氯代氰基化合物的方法。 这些化合物用作电化学或光电器件如电池和太阳能电池中的离子液体。 [化学式7] [（Z 1（Q 1）6-m（CN）m） - ] n（I）还公开了由式（Ia）表示的式（I）亚类的电解质配方和化合物。 [（n-Bu）4 N] [顺式-PF 2（CN）4]，Ag [顺式 -PF 2（CN）4]，K [顺式 - PF 2（CN）4]，Li [顺式 - PF 2（CN）4]，[Et 3 H N] [[顺式-PF 2（CN） （n-Bu）4P] [顺式-PF 2（CN）4]，[H30] [顺式 - PF2（CN）4]，Mg [顺式 - PF 2（CN）4] 2 * 4H 20，Zn [ -PF 2（CN）4] 2 * 2H 20，[H 50 2] [Cis-PF 2（CN）4]

公开(公告)号：WO2018041853A1

公开(公告)日：2018-03-08

申请号：PCT/EP2017/071690

申请日：2017-08-30

Applicant: LONZA LTD

Inventor： ZARAGOZA DOERWALD, Florencio ,  TAESCHLER, Christoph ,  CARREIRA, Erick

IPC: C07D241/24

CPC classification number: C07D241/24

Abstract: The invention discloses a method for the preparation of 3-(trifluoromethyl)pyrazine-2-carboxylic acid esters starting from alkyl 4,4,4-trifluoro-2-(hydroxyimino)-3-oxobutanoates by reaction with ethylenediamine.

Abstract translation: 本发明公开了由4,4,4-三氟-2-（羟基亚氨基）-3-氧代丁酸烷基酯开始制备3-（三氟甲基）吡嗪-2-羧酸酯的方法， 与乙二胺反应。

公开(公告)号：WO2017084995A1

公开(公告)日：2017-05-26

申请号：PCT/EP2016/077531

申请日：2016-11-14

Applicant: LONZA LTD

Inventor： TAESCHLER, Christoph ,  GIRARD, Christophe ,  TONAZZI, Sandro ,  POLENSKE, Daniel ,  GARMS, Stefan ,  ESCHER, Christoph ,  LORENZ, Andreas ,  BINER, Sonja ,  VON DER GRUEN, Mareile ,  KUEHBERGER, Herbert ,  ZURBRIGGEN, Jonas ,  IN-ALBON, Dieter ,  LUTZ, Beat

IPC: C07D231/20

CPC classification number: C07D231/20

Abstract: The invention discloses a method for the preparation of 1-methyl-3-(trifluoromethyl)-1H- pyrazol-5-ol with high selectivity with respect to the content of the isomer 1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-ol.

Abstract translation: 本发明公开了一种制备1-甲基-3-（三氟甲基）-1H-吡唑-5-醇的方法，该方法相对于异构体1-甲基-5 - （三氟甲基）-1H-吡唑-3-醇

公开(公告)号：WO2016162400A1

公开(公告)日：2016-10-13

申请号：PCT/EP2016/057584

申请日：2016-04-07

Applicant: LONZA LTD

Inventor： ELLINGER, Stefan ,  TAESCHLER, Christoph ,  ZUR TAESCHLER, Cornelia ,  SIEVERT, Katharina ,  SCHULZ, Axel ,  HARLOFF, Jörg

IPC: C07F9/02 ,  C01B25/00 ,  C09K19/00 ,  H01M10/0568

CPC classification number: C07F9/02 ,  C01B35/063 ,  H01M10/0569 ,  H01M2300/0045

Abstract: The invention discloses a method for preparation of cyano compounds of boron with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Cat n+ ] [(BF 4-m (CN)m) - ] n by a reaction of compound of formula (A1) with trimethylsilylcyanide in the presence of a Bronstedt acid; [Cat n+ ] [(BF 4 ) - ] n (A1); n+ Cat is a cation, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4. In a specific embodiment, the method is for prepration of the following three compounds: [(n-Bu) 4 N][BF(CN) 3 ] (1), [(n-Pr) 3 NH][BF(CN) 3 ] (2), [(n-Pr) 3 NH][B(CN) 4 ] (3).

Abstract translation: 本发明公开了通过式（I）代表的具有1,2,3或4个氰基的硼的氰基化合物的制备方法：[Catn +] [（BF4-m（CN）m） - ] n通过 在布朗斯台德酸存在下，式（A1）化合物与三甲基甲硅烷基氰化物反应; [Catn +] [（BF4） - ] n（A1）; n + Cat为阳离子，m为1,2,3或4，n为1,2,3或4.在具体实施方案中，该方法用于制备以下三种化合物：[（n-Bu）4 N] [BF（CN）3]（1），[（n-Pr）3NH] [BF（CN）3]（2），[（n-Pr）3 NH] [B（CN）4]（3）。