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公开(公告)号：WO2016049367A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/052046
申请日：2015-09-24
Applicant: LOS ALAMOS NATIONAL SECURITY, LLC , PRZEKWAS, Andrzej
Inventor： PRZEKWAS, Andrzej , IYER, Rashi , HARRIS, Jennifer, F. , HUANG, Jen-Huang , NATH, Pulak
CPC classification number: G01N33/5064 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0627 , B01L2300/0681 , B01L2300/0832 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0633 , C12N5/06 , C12N5/067 , F16K7/045 , G01N33/5008 , G01N33/5014 , G01N33/5082
Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.
Abstract translation: 本文公开的是培养细胞，组织和/或器官的培养基。 本文公开的培养基制剂可用于支持一种或多于一种细胞类型，组织或器官的生长，活力和/或功能。 在一些实施方案中，在足以支持细胞类型，组织和/或器官的生长，活力和/或功能的条件下，将一种或多种细胞类型，组织，器官器官和/或器官与公开的培养基接触 。 所公开的介质可以用于培养多种细胞类型的方法，并且在一些实例中，例如用于包括一种或多种器官器官的平台装置中，例如通过使介质循环通过平台中的一个或多个器官器官。
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公开(公告)号：WO2016049365A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/052043
申请日：2015-09-24
Applicant: LOS ALAMOS NATIONAL SECURITY, LLC
Inventor： IYER, Rashi , NATH, Pulak , HUANG, Jen-Huang
CPC classification number: G01N33/5064 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0627 , B01L2300/0681 , B01L2300/0832 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0633 , C12N5/06 , C12N5/067 , F16K7/045 , G01N33/5008 , G01N33/5014 , G01N33/5082
Abstract: Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations thereof. The devices disclosed herein are cost-efficient and user-friendly and can be implemented in a variety of reactor systems.
Abstract translation: 这里公开了用于管理流体输送的装置的实施例。 在特别公开的实施例中，该装置用于管理反应器系统中的流体输送，例如生物评估系统，化学合成反应器等。 本文公开的装置包括流体管理装置，储存器组件，阀门系统，泵及其组合。 本文公开的装置具有成本效益和用户友好性，并且可以在各种反应器系统中实现。
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公开(公告)号：WO2016049363A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/052039
申请日：2015-09-24
Applicant: LOS ALAMOS NATIONAL SECURITY, LLC
Inventor： IYER, Rashi , HUANG, Jen-Huang , NATH, Pulak , HARRIS, Jennifer
CPC classification number: G01N33/5064 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0627 , B01L2300/0681 , B01L2300/0832 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0633 , C12N5/06 , C12N5/067 , F16K7/045 , G01N33/5008 , G01N33/5014 , G01N33/5082
Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.
Abstract translation: 本文公开了可用于模拟肺器官的生化和生理作用的装置的实施方案。 本文还公开了包括在装置中的部件的实施例以及制造和使用该装置的方法。 进一步公开的平台装置实施例和其中使用的各种部件可以与本文公开的肺器官装置组合使用。 在一些实施方案中，所公开的装置可用于确定药物毒性，并且还可与一种或多种疾病模型一起使用以确定治疗疾病的方法。
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