公开(公告)号：WO2009026060A2

公开(公告)日：2009-02-26

申请号：PCT/US2008072978

申请日：2008-08-13

Applicant: MALLINCKRODT INC ,  WAGNER GARY S ,  FAGO FRANK M ,  STAATS PETER ,  BATTIATO DANE

Inventor： WAGNER GARY S ,  FAGO FRANK M ,  STAATS PETER ,  BATTIATO DANE

IPC: A61M5/145 ,  A61M5/142

CPC classification number: A61B5/055 ,  A61M5/007 ,  A61M5/14216 ,  A61M5/14228 ,  A61M5/14526 ,  A61M5/1454 ,  A61M5/16827 ,  A61M39/08 ,  A61M2005/14513

Abstract: Some injectors of the invention may include a fluid drive responsive to pressure of a working fluid (e.g., liquid, pneumatic, or both) to impart a sequence of forces to drive a delivery device (e.g., a syringe) to deliver a medical fluid (e.g., a contrast agent, a radiopharmaceutical, a drug, or a combination thereof). Some injectors may include a multimedia tube configured to pass a working fluid (e.g., air) and a light signal (e.g., infrared). Some injectors may include a peristaltic drive responsive to pressure of a working fluid.

Abstract translation: 本发明的一些注射器可以包括响应于工作流体（例如液体，气动或两者）的压力的流体驱动器，以施加一系列的力来驱动输送装置（例如，注射器）输送医用流体（ 例如造影剂，放射性药物，药物或其组合）。 一些喷射器可以包括配置成通过工作流体（例如空气）和光信号（例如，红外线）的多媒体管。 一些注射器可以包括响应于工作流体的压力的蠕动驱动器。

公开(公告)号：WO2007016171A3

公开(公告)日：2007-06-07

申请号：PCT/US2006029056

申请日：2006-07-26

Applicant: MALLINCKRODT INC ,  FAGO FRANK M ,  WILSON DAVID W ,  WAGNER GARY S ,  POLLARD RALPH E JR

Inventor： FAGO FRANK M ,  WILSON DAVID W ,  WAGNER GARY S ,  POLLARD RALPH E JR

IPC: G21F5/015

CPC classification number: G21F5/015 ,  Y10T29/49 ,  Y10T29/49826

Abstract: In one characterization, the present invention relates to a radiation-shielding assembly for holding a container having a radioactive material disposed therein. The assembly may, at least in one regard, be referred to as an elution shield and/or a dispensing shield. The assembly includes a body at least partially defining a cavity. There is at least one opening through the body into the cavity. The assembly may include a cap that at least generally hinders escape of radiation from the assembly through the opening. The cap may be releasably attached to the body in one orientation and may establish non-attached engagement with the body in another orientation. The assembly may include an adjustable spacer system for adapting the assembly for use with containers having different heights.

Abstract translation: 在一个表征中，本发明涉及一种用于保持放置有放射性材料的容器的辐射屏蔽组件。 至少在一个方面，组件可以被称为洗脱屏蔽和/或分配屏蔽。 组件包括至少部分地限定空腔的主体。 通过身体至少有一个开口进入腔体。 组件可以包括帽，其至少通常阻止辐射通过开口从组件逃逸。 帽可以以一个取向可释放地附接到身体，并且可以在另一取向上与身体建立非附着的接合。 组件可以包括可调节间隔器系统，用于使组件适应于具有不同高度的容器。

公开(公告)号：WO0103757A3

公开(公告)日：2001-09-07

申请号：PCT/US0019275

申请日：2000-07-14

Applicant: MALLINCKRODT INC

Inventor： SMALL JAMES R ,  FAGO FRANK M ,  WAGNER GARY S ,  SMITH MITCHELL A ,  TYSON JOSEPH B

IPC: A61L2/10 ,  A61J3/00 ,  A61L2/16 ,  A61L2/18 ,  A61L2/22 ,  A61M5/00 ,  A61M5/142 ,  A61M5/162 ,  A61M5/31 ,  A61M39/02 ,  A61M39/16

CPC classification number: A61J3/002 ,  A61J2200/76 ,  A61J2205/10 ,  A61J2205/60 ,  A61M5/007 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/162 ,  A61M39/16 ,  A61M39/162 ,  A61M39/165 ,  A61M2005/3128

Abstract: A system (10) to provide a specified volume of a medical fluid (23) from a bulk source (14) to a dose and/or delivery container (16) for injection into a patient. The fluid path (50, 100) between the bulk container (14) and the delivery container (16) is physically separated at a connecting site (66) before fluid (23) is injected from the delivery container (16) into the patient. The bulk container (14) may be a bag or bottle, and the delivery container (16) may be a syringe (81) or bag (28). A bag (28) delivery container (16) may be contained in a pressurizeable chamber (30) and fluid (23) may be delivered by providing pressure to a membrane (52) in the chamber (30) contacting a wall of the bag (28). The system (10) may be automated.

Abstract translation: 一种系统（10），用于从体积源（14）向剂量和/或输送容器（16）提供指定体积的医用流体（23），用于注射到患者体内。 在将流体（23）从输送容器（16）注入患者体内之前，散装容器（14）和输送容器（16）之间的流体路径（50,100）在连接位置（66）处物理分离。 散装容器（14）可以是袋或瓶，并且输送容器（16）可以是注射器（81）或袋（28）。 袋（28）输送容器（16）可以容纳在可加压室（30）中，并且流体（23）可以通过向腔室（30）中的膜（52）提供压力而被输送，所述膜（52）接触袋的壁 28）。 系统（10）可以是自动的。

公开(公告)号：WO2008076150A3

公开(公告)日：2008-11-06

申请号：PCT/US2007015948

申请日：2007-07-12

Applicant: MALLINCKRODT INC ,  BRUCE JOHN K ,  FAGO FRANK M

Inventor： BRUCE JOHN K ,  FAGO FRANK M

IPC: A61M5/178 ,  G21F5/018

CPC classification number: A61M5/1785 ,  A61M2005/312 ,  A61M2005/3128 ,  G21F5/018

Abstract: The application relates to radiation shielding (12) for use with radiopharmaceutical syringes (14). For example, in at least some regards, the invention relates to a syringe radiation shield that includes a sleeve (18) having a syringe receptacle defined therein to accommodate a barrel (26) of the syringe. In addition, this syringe radiation shield may also include a cover (20) having a plunger receptacle defined therein to accommodate a plunger of the syringe. The sleeve and the cover may be removably coupled wit one another so that the syringe can be housed within the syringe radiation shield, for example, during administration of a radiopharmaceutical from the syringe.

Abstract translation: 本申请涉及用于放射性药物注射器（14）的辐射屏蔽（12）。 例如，至少在某些方面，本发明涉及一种注射器辐射屏蔽，其包括套筒（18），其具有限定在其中的注射器容器，以容纳针筒的筒体（26）。 此外，该注射器辐射屏蔽还可以包括具有限定在其中的柱塞接收器以容纳注射器的柱塞的盖（20）。 套筒和盖可以彼此可移除地连接，使得注射器可以容纳在注射器辐射屏蔽内，例如在从注射器施用放射性药物期间。

公开(公告)号：WO2007016172A2

公开(公告)日：2007-02-08

申请号：PCT/US2006029057

申请日：2006-07-26

Applicant: MALLINCKRODT INC ,  WAGNER GARY S ,  WILSON DAVID W ,  FAGO FRANK M ,  POLLARD JR RALPH E

Inventor： WAGNER GARY S ,  WILSON DAVID W ,  FAGO FRANK M ,  POLLARD JR RALPH E

IPC: G21G4/08 ,  G21F5/015

CPC classification number: G21G4/00 ,  G21F5/015 ,  G21Y2002/207 ,  G21Y2002/303 ,  G21Y2002/501 ,  G21Y2004/30

Abstract: The invention, in one characterization, may be said to be directed to an alignment adapter that may be utilized in radioisotope elution procedures. In some embodiments, the alignment adaptor may be utilized to at least assist in aligning various components of an elution system. For example, in some embodiments, the alignment adaptor may be utilized to at least generally assist in aligning an aperture defined in a lid of the elution system and an elution needle of a radioisotope generator. In some embodiments, the alignment adaptor may be utilized to at least generally assist in aligning an elution assembly (e.g., elution shield housing an eluate vial) and an elution needle of a radioisotope generator. Further, in some embodiments, the alignment adaptor may be utilized to at least generally assist in aligning an eluant container (e.g., bottle of eluant) and a needle of a radioisotope generator.

Abstract translation: 在一个表征中，本发明可以说是针对可用于放射性同位素洗脱程序的对准适配器。 在一些实施方案中，对准适配器可用于至少有助于排列洗脱系统的各种组分。 例如，在一些实施例中，对准适配器可以用于至少大体上有助于对齐限定在洗脱系统的盖子中的孔和放射性同位素发生器的洗脱针。 在一些实施方案中，对准适配器可用于至少大体上有助于使洗脱组件（例如，洗脱屏蔽罩住洗脱液瓶）和放射性同位素发生器的洗脱针排列。 此外，在一些实施例中，对准适配器可用于至少大体上有助于对齐洗脱液容器（例如，瓶的洗脱液）和放射性同位素发生器的针。

公开(公告)号：WO2006130681A3

公开(公告)日：2007-04-26

申请号：PCT/US2006021108

申请日：2006-05-31

Applicant: MALLINCKRODT INC ,  HYNES MICHAEL R ,  FAGO FRANK M

Inventor： HYNES MICHAEL R ,  FAGO FRANK M

IPC: A61M5/44

CPC classification number: A61M5/445 ,  A61M5/007 ,  A61M2205/3633

Abstract: The present invention relates to heat-retaining syringe jackets for reducing the cooling rate of medical fluids held inside syringes and methods of using such syringe jackets. An exemplary syringe jacket of the invention may include a material that experiences a phase transition at a phase transition temperature. Additionally or alternatively, the exemplary syringe jacket may include a material exhibiting a high specific heat.

Abstract translation: 本发明涉及用于降低保持在注射器内部的医疗液体的冷却速度的保温注射器护套和使用这种注射器护套的方法。 本发明的示例性注射器套管可以包括在相变温度下经历相变的材料。 另外或替代地，示例性注射器套管可以包括表现出高比热的材料。

公开(公告)号：WO2006124775A3

公开(公告)日：2007-04-12

申请号：PCT/US2006018727

申请日：2006-05-16

Applicant: MALLINCKRODT INC ,  WAGNER GARY S ,  FAGO FRANK M ,  GRISPO KEITH M ,  GIBSON CHAD M ,  LEWIS JOHN H ,  BAUSMITH WILLIAM E ,  HAYNES ELAINE E ,  WILSON DAVID W ,  ORTENZI VERNON D ,  BORGEMENKE ELAINE

Inventor： WAGNER GARY S ,  FAGO FRANK M ,  GRISPO KEITH M ,  GIBSON CHAD M ,  LEWIS JOHN H ,  BAUSMITH WILLIAM E ,  HAYNES ELAINE E ,  WILSON DAVID W ,  ORTENZI VERNON D ,  BORGEMENKE ELAINE

IPC: A61M5/178 ,  A61M5/145 ,  A61N5/10 ,  G01N23/10 ,  G01T7/02 ,  G21F5/015 ,  G21F5/018

CPC classification number: A61M5/14546 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/172 ,  A61M5/1785 ,  A61M2005/14506 ,  A61M2205/60 ,  A61M2205/6018 ,  G06K2017/009

Abstract: Certain embodiments of the invention relate to a radiopharmaceutical system having a shielded cordless injector and various radiopharmaceutical pig and syringe structures that permit the syringe to remain in the pig during transportation and use of the syringe. In some embodiments, the shielded cordless injector may include an injector, a radiation shield disposed at least partially about the injector, a drive coupled to the injector, and an energy storage device coupled to the drive. The pig may have a computer with a display screen that displays a radioactivity level of a radiopharmaceutical and/or a desired (e.g., correct) unit dose volume of a radiopharmaceutical to be administered to a patient.

Abstract translation: 本发明的某些实施例涉及具有屏蔽无绳注射器和各种放射性药物猪和注射器结构的放射性药物系统，其允许注射器在注射器的运输和使用期间保持在猪中。 在一些实施例中，屏蔽无绳注射器可以包括注射器，至少部分地围绕注射器设置的辐射屏蔽，耦合到注射器的驱动器以及耦合到驱动器的能量存储装置。 猪可以具有显示屏幕的计算机，其显示放射性药物的放射性水平和/或待给予患者的放射性药物的期望（例如，正确的）单位剂量体积。

公开(公告)号：WO2006124891A3

公开(公告)日：2007-01-18

申请号：PCT/US2006018905

申请日：2006-05-12

Applicant: MALLINCKRODT INC ,  FAGO FRANK M

Inventor： FAGO FRANK M

IPC: G21F5/018 ,  A61M5/178

CPC classification number: G21F5/018 ,  A61M5/1785 ,  A61M5/3202 ,  A61M5/3204 ,  A61M2005/3215 ,  G21Y2002/207 ,  G21Y2002/208 ,  G21Y2002/304 ,  G21Y2002/50 ,  G21Y2004/30 ,  G21Y2004/40

Abstract: According to at least one aspect, the present invention is directed a radiation-shielding container for holding a radiopharmaceutical syringe including a needle and a syringe cap covering the needle. This radiation-shielding container is equipped with what may be characterized as a cap retainer for selectively holding the syringe cap. The syringe cap may be held by the cap retainer so that an open end of the cap is oriented for insertion of the needle into the cap. The radiopharmaceutical syringe may be used to administer a radiopharmaceutical to a patient and thereby result in what is commonly referred to as a spent radiopharmaceutical syringe. The hypodermic needle of the spent radiopharmaceutical syringe may be inserted into the syringe cap while the syringe cap is held by the cap retainer to secure the syringe cap to the syringe.

Abstract translation: 根据至少一个方面，本发明涉及一种用于保持放射性药剂注射器的放射线屏蔽容器，所述放射线药剂注射器包括针头和覆盖针的注射器帽。 该辐射屏蔽容器配备有可以被表征为用于选择性地保持注射器盖的盖保持器。 注射器帽可以由帽保持器保持，使得帽的开口端被定向成将针插入帽中。 放射性药物注射器可用于向患者施用放射性药物，从而导致通常称为废弃放射性药物注射器。 废弃的放射性药剂注射器的皮下注射针可以插入到注射器盖中，同时注射器帽由帽保持器保持以将注射器帽固定到注射器。

公开(公告)号：WO2005065747A2

公开(公告)日：2005-07-21

申请号：PCT/US2004041225

申请日：2004-12-09

Applicant: MALLINCKRODT INC ,  FAGO FRANK M ,  BERGEN ROBERT ,  FARMER JAMES F

Inventor： FAGO FRANK M ,  BERGEN ROBERT ,  FARMER JAMES F

IPC: A61M5/00 ,  A61M5/145 ,  A61M5/178

CPC classification number: A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/1782 ,  A61M2209/082

Abstract: The filling of a syringe can be performed at a faster rate using a filling sequence which expels air from the fill tube before filling the syringe. A similar method is used when changing contrast containers during a filling sequence to ensure that all the air is expelled from the fill tube before filling resumes with the new contrast container. Additionally, by including a contrast container holder that is affixed to an injector head and holds the container near the syringe tip, the filling sequence can be accomplished without requiring the operator to hold the contrast container during the sequence.

Abstract translation: 注射器的填充可以使用在填充注射器之前从填充管排出空气的填充序列以更快的速率进行。 在填充过程中更换造影剂容器时使用类似的方法，以确保在用新的造影剂容器重新填充之前，所有的空气都从填充管中排出。 此外，通过包括固定在注射器头部上并将容器保持在注射器尖端附近的造影剂容器支架，可以在不需要操作者在顺序期间握住造影剂容器的情况下完成填充序列。

公开(公告)号：WO2010051205A3

公开(公告)日：2010-10-07

申请号：PCT/US2009061568

申请日：2009-10-22

Applicant: MALLINCKRODT INC ,  FAGO FRANK M

Inventor： FAGO FRANK M

IPC: A61M5/14

CPC classification number: A61M5/14546 ,  A61B6/548 ,  A61M5/007 ,  A61M5/1407 ,  A61M5/1413 ,  A61M5/14216 ,  A61M5/1456 ,  A61M5/162 ,  A61M5/16827 ,  A61M5/445 ,  A61M39/08 ,  A61M2005/14553 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/3653 ,  A61M2205/6054

Abstract: A multi-dose injection system (108) is disclosed that allows for safe and easy use of bulk containers, a multi-use tubing set (110), and syringes (86a, 86b) across multiple patients. The bulk containers may include a saline bottle (118) and a contrast bottle (120) for administration to a series of patients undergoing imaging procedures. The bottles (118, 120) may be fluidly connected to a cassette (114) that includes a saline valve (176) and a contrast valve (178) operable to control flow from the saline bottle (118) and the contrast bottle (120), respectively. The cassette (114) may be fluidly interconnected to the multi-use tubing set (110) that is, in turn, fluidly connected to syringes (86a, 86b) on a powerhead (50) and a patient-specific tubing set (112). The patient-specific tubing set (112) may be replaced between patients and may also serve to isolate the remainder of the multi-dose injection system (108) from contamination from bodily fluids.

Abstract translation: 公开了多剂量注射系统（108），其允许跨多个患者安全且容易地使用散装容器，多用途管组（110）和注射器（86a，86b）。 散装容器可以包括生理盐水瓶（118）和造影剂瓶（120），用于向正在进行成像程序的一系列患者施用。 瓶（118,120）可以流体连接到包括盐水阀（176）和可操作以控制来自盐水瓶（118）和对比瓶（120）的流动的对比阀（178）的盒（114） ， 分别。 盒114可流体地互连到多用途管组110，多用管组110又流体地连接到动力头50上的注射器86a和86b以及患者专用管组112， 。 患者特异性管道组（112）可以在患者之间进行替换，并且还可以用于将多剂量注射系统（108）的其余部分与来自体液的污染隔离。