公开(公告)号：WO2015100343A1

公开(公告)日：2015-07-02

申请号：PCT/US2014/072186

申请日：2014-12-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  EDELMAN, Elazer R. ,  KELMANSKY, Regina ,  CERVANTES, Marc Mier

IPC: A61L27/20 ,  A61L27/50 ,  A61K9/00 ,  A61L24/00 ,  A61L24/08

CPC classification number: A61K31/785 ,  A61K9/0019 ,  A61K47/34 ,  A61L24/001 ,  A61L24/08 ,  A61L27/20 ,  A61L27/50 ,  C08L5/02

Abstract: Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.

Abstract translation: 提供了处理，粘附或密封生物组织的方法。 所述方法包括组合含有能够彼此反应的聚合物组分和树枝状大分子组分的溶液，并且至少一种组分包括能够可逆地二聚的能够进行可光反应的二聚化的取代基。 还提供了含有这两种组分的药物递送组合物和试剂盒。

公开(公告)号：WO2016210112A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/038991

申请日：2016-06-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  EDELMAN, Elazer R. ,  KELMANSKY, Regina ,  CERVANTES, Marc Mier ,  ZHANG, Yi

IPC: A61L24/00 ,  A61L24/04 ,  A61L26/00

CPC classification number: A61L24/043 ,  A61L24/0015 ,  A61L26/0052 ,  A61L26/0066 ,  C08L5/02 ,  C08L101/005

Abstract: Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.

Abstract translation: 提供了用于治疗，粘附或密封生物组织的方法，组合物，试剂盒和药物递送装置。 所述方法包括组合包含低聚物/聚合物组分的第一溶液和包含树枝状大分子组分的第二溶液，并且至少一种低聚物/聚合物组分和树枝状聚合物组分包括至少一个能够进行可光反应二聚的取代基。 取代基的可逆二聚可以允许一种或多种组分的可逆二聚和/或聚合。 能够进行光可逆二聚化的取代基可以通过施加诸如UV光的光而具有活性。