公开(公告)号：WO2017196986A1

公开(公告)日：2017-11-16

申请号：PCT/US2017/031968

申请日：2017-05-10

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： EDELMAN, Elazer R. ,  ARTZI, Natalie ,  OLIVA, Nuria

IPC: A61K47/56

CPC classification number: A61K47/59 ,  A61K31/704 ,  A61K47/595 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6903 ,  A61M5/19 ,  A61P35/00

Abstract: Abstract of the Disclosure Provided herein are compositions that include a dendrimer to which a drug and a binding peptide are conjugated. The binding peptide may be configured to bind to a receptor that is overexpressed by a diseased cell, such as a cancer cell. The compositions may include a hydrogel in which the dendrimer-drug conjugate is dispersed. Methods of drug delivery and kits also are provided.

Abstract translation: 本公开的摘要是包括药物和结合肽缀合于其上的树枝状聚合物的组合物。 结合肽可以被配置成结合由患病细胞（例如癌细胞）过表达的受体。 组合物可以包括其中分散有树状聚合物 - 药物缀合物的水凝胶。 还提供了药物递送方法和试剂盒。

公开(公告)号：WO2015100343A1

公开(公告)日：2015-07-02

申请号：PCT/US2014/072186

申请日：2014-12-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  EDELMAN, Elazer R. ,  KELMANSKY, Regina ,  CERVANTES, Marc Mier

IPC: A61L27/20 ,  A61L27/50 ,  A61K9/00 ,  A61L24/00 ,  A61L24/08

CPC classification number: A61K31/785 ,  A61K9/0019 ,  A61K47/34 ,  A61L24/001 ,  A61L24/08 ,  A61L27/20 ,  A61L27/50 ,  C08L5/02

Abstract: Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.

Abstract translation: 提供了处理，粘附或密封生物组织的方法。 所述方法包括组合含有能够彼此反应的聚合物组分和树枝状大分子组分的溶液，并且至少一种组分包括能够可逆地二聚的能够进行可光反应的二聚化的取代基。 还提供了含有这两种组分的药物递送组合物和试剂盒。

公开(公告)号：WO2022182975A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017877

申请日：2022-02-25

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： BROWN, Jonathan ,  EDELMAN, Elazer R. ,  MURPHY, Michael

IPC: A61B5/05 ,  G06G7/60

Abstract: A method includes determining, by a computer processor coupled to memory, data associated with a patient, the data comprising a heart rate value, a peak velocity through aortic valve value, and a stroke volume value; generating a flow waveform for the patient using the data; determining a set of candidate vascular impedance (VI) values for the patient based at least in part on the flow waveform, the set of candidate VI values comprising first and second VI values; determining a first pressure waveform using the flow waveform and the first VI value; determining a second pressure waveform using the flow waveform and the second VI value; determining a blood pressure value for the patient; determining that the first pressure waveform is a closer match to the blood pressure value than the second pressure waveform; and determining that the patient has a vascular impedance of the first VI value.

公开(公告)号：WO2019246301A1

公开(公告)日：2019-12-26

申请号：PCT/US2019/038039

申请日：2019-06-19

Applicant: ABIOMED, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  EL KATERJI, Ahmad ,  TAN, Qing ,  MOYER, Christian ,  SHIP, Alexander ,  BHAVSAR, Sonya Sanat ,  JOSEPHY, Noam ,  EDELMAN, Elazer R. ,  CHANG, Brian Yale ,  KELLER, Steven

Inventor： EL KATERJI, Ahmad ,  TAN, Qing ,  MOYER, Christian ,  SHIP, Alexander ,  BHAVSAR, Sonya Sanat ,  JOSEPHY, Noam ,  EDELMAN, Elazer R. ,  CHANG, Brian Yale ,  KELLER, Steven

IPC: A61B5/02 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/021 ,  A61B5/00 ,  A61M1/10 ,  A61M1/12

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

公开(公告)号：WO2016210112A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/038991

申请日：2016-06-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  EDELMAN, Elazer R. ,  KELMANSKY, Regina ,  CERVANTES, Marc Mier ,  ZHANG, Yi

IPC: A61L24/00 ,  A61L24/04 ,  A61L26/00

CPC classification number: A61L24/043 ,  A61L24/0015 ,  A61L26/0052 ,  A61L26/0066 ,  C08L5/02 ,  C08L101/005

Abstract: Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.

Abstract translation: 提供了用于治疗，粘附或密封生物组织的方法，组合物，试剂盒和药物递送装置。 所述方法包括组合包含低聚物/聚合物组分的第一溶液和包含树枝状大分子组分的第二溶液，并且至少一种低聚物/聚合物组分和树枝状聚合物组分包括至少一个能够进行可光反应二聚的取代基。 取代基的可逆二聚可以允许一种或多种组分的可逆二聚和/或聚合。 能够进行光可逆二聚化的取代基可以通过施加诸如UV光的光而具有活性。

公开(公告)号：WO2014169137A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/033671

申请日：2014-04-10

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： INDOLFI, Laura ,  EDELMAN, Elazer R. ,  LANGER, Robert S. ,  CLARK, Jeffrey W. ,  TING, David T. ,  FERRONE, Cristina Rosa Annamaria ,  LIGORIO, Matteo

IPC: A61L31/10 ,  A61K47/34 ,  A61K9/70 ,  A61F2/04

CPC classification number: A61L31/10 ,  A61F2/915 ,  A61F2002/041 ,  A61F2230/0021 ,  A61K9/0024 ,  A61K9/0034 ,  A61K9/7007 ,  A61K31/337 ,  A61K47/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2420/06 ,  C08L67/04

Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 µm to about 1000 µm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

Abstract translation: 提供了用于治疗胰腺，胆汁系统，胆囊，肝脏，小肠或结肠肿瘤的药物洗脱装置和方法。 方法包括部署具有膜的药物洗脱装置，该膜包括可降解聚合物和化学治疗药物的混合物，其中所述膜具有约2μm至约1000μm的厚度进入组织部位并释放治疗有效量的 来自膜的化疗药物以治疗肿瘤，其中通过在组织部位的聚合物的体内降解来控制来自膜的治疗有效量的药物的释放。