公开(公告)号：WO2017201407A1

公开(公告)日：2017-11-23

申请号：PCT/US2017/033542

申请日：2017-05-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  OLIVA JORGE, Nuria ,  ZHANG, Yi ,  CONDE, Joao

IPC: C07D309/14 ,  A61K9/06 ,  A61K9/10 ,  A61K31/351 ,  A61K31/704 ,  A61K47/36 ,  A61P35/00

Abstract: A hydrogel particle comprising: cross-linked dextran aldehyde (oxidized dextran), comprising the redox sensitive disulfide cross-linker cystamine (2,2'-disulfanediyldiethanamine), the anti-tumor agent doxorubicin conjugated to the cross-linked polymer by a pH sensitive imine bond and the cell penetrating peptide RGD, for use in chemotherapy.

Abstract translation: 水凝胶颗粒包含：交联葡聚糖醛（氧化葡聚糖），其包含氧化还原敏感的二硫化物交联剂胱胺（2,2'-二硫烷二基二乙胺），抗肿瘤剂多柔比星与 交联聚合物通过pH敏感的亚胺键和细胞穿透肽RGD用于化学疗法。

公开(公告)号：WO2003068065A1

公开(公告)日：2003-08-21

申请号：PCT/US2003/004591

申请日：2003-02-14

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ZHANG, Yi ,  ASADA, Haruhiko, H.

IPC: A61B5/02

CPC classification number: H04L25/0242 ,  A61B5/02 ,  A61B5/029 ,  H04L25/0204 ,  H04L25/0238

Abstract: Multi-channel blind system identification is utilized to identify a system input from non-invasive measurements of a system output. A cardiovascular system is used to illustrate the method. The system's transfer functions can be formulated with an autoregression moving average model utilizing finite impulse response or a group of infinite impulse responses. Both these models identify the system functions by solving a set of linear equations using the least-squares method. The system input is then identified by deconvolving the system output and the estimated impulse response of each channel. These models can be augmented to obtain an estimate of the maximum order of the cardiac functions when they are unknown a priori. The approach can also be modified to obtain the functions by first resolving the distinct dynamics associated with each channel, then determining the common dynamics, and ultimately determining the system input.

Abstract translation: 多通道盲系统识别用于从系统输出的非侵入性测量中识别系统输入。 心血管系统用于说明该方法。 系统的传递函数可以利用有限脉冲响应或一组无限脉冲响应的自回归移动平均模型来制定。 这两种模型通过使用最小二乘法求解一组线性方程来识别系统功能。 然后通过对系统输出进行去卷积和每个通道的估计脉冲响应来识别系统输入。 可以增加这些模型，以便在先验未知时获得心脏功能的最大顺序的估计。 还可以通过首先解决与每个通道相关的不同动力，然后确定共同的动力学，最终确定系统输入，来修改该方法以获得功能。

公开(公告)号：WO2016210112A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/038991

申请日：2016-06-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ARTZI, Natalie ,  EDELMAN, Elazer R. ,  KELMANSKY, Regina ,  CERVANTES, Marc Mier ,  ZHANG, Yi

IPC: A61L24/00 ,  A61L24/04 ,  A61L26/00

CPC classification number: A61L24/043 ,  A61L24/0015 ,  A61L26/0052 ,  A61L26/0066 ,  C08L5/02 ,  C08L101/005

Abstract: Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.

Abstract translation: 提供了用于治疗，粘附或密封生物组织的方法，组合物，试剂盒和药物递送装置。 所述方法包括组合包含低聚物/聚合物组分的第一溶液和包含树枝状大分子组分的第二溶液，并且至少一种低聚物/聚合物组分和树枝状聚合物组分包括至少一个能够进行可光反应二聚的取代基。 取代基的可逆二聚可以允许一种或多种组分的可逆二聚和/或聚合。 能够进行光可逆二聚化的取代基可以通过施加诸如UV光的光而具有活性。