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公开(公告)号：WO2015100343A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/072186
申请日：2014-12-23
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ARTZI, Natalie , EDELMAN, Elazer R. , KELMANSKY, Regina , CERVANTES, Marc Mier
CPC classification number: A61K31/785 , A61K9/0019 , A61K47/34 , A61L24/001 , A61L24/08 , A61L27/20 , A61L27/50 , C08L5/02
Abstract: Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.
Abstract translation: 提供了处理，粘附或密封生物组织的方法。 所述方法包括组合含有能够彼此反应的聚合物组分和树枝状大分子组分的溶液，并且至少一种组分包括能够可逆地二聚的能够进行可光反应的二聚化的取代基。 还提供了含有这两种组分的药物递送组合物和试剂盒。
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2.发明申请THERANOSTIC NANOPROBES FOR OVERCOMING CANCER MULTIDRUG RESISTANCE AND METHODS 审中-公开用于覆盖癌症多药耐药性和方法的神经病性纳豆
公开(公告)号：WO2016134232A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018632
申请日：2016-02-19
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ARTZI, Natalie , CONDE, Joao , OLIVA, Nuria
IPC: A61K33/24 , A61K31/713 , A61K47/48
CPC classification number: A61K47/48884 , A61K31/513 , A61K31/713 , A61K33/24 , A61K47/6923 , A61K49/0032 , A61K49/0054 , A61K49/0065 , A61K49/0093 , A61K2300/00 , A61K31/24
Abstract: Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The theranostic nanoprobes may include gold nanoparticles functionalized with DNA-hairpin. The DNA-hairpin may be configured to hybridize to a complementary target, which may silence or lessen the multidrug resistance of cancer cells. The theranostic nanoprobes may be configured to release a chemotherapeutic agent upon hybridization of the DNA-hairpin to a target molecule.
Abstract translation: 提供了纳曲酮纳米探针以克服癌症多药耐药性，以及用于治疗生物组织（包括癌组织）的方法。 衍生物纳米探针可以包括用DNA-发夹官能化的金纳米颗粒。 DNA发夹可以被配置为与互补靶物杂交，其可以沉默或减轻癌细胞的多药耐药性。 衍生物纳米探针可以被配置为在DNA-发夹与靶分子杂交时释放化学治疗剂。
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公开(公告)号：WO2022183126A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/018205
申请日：2022-02-28
Inventor： ARTZI, Natalie , DOSTA, Pere , PUIGMAL, Nuria , SOLHJOU, Zhabiz , YATIM, Karim , AZZI, Jamil
Abstract: The present disclosure describes methods of treating a skin disorder in a subject in need thereof and methods of locally suppressing an immune response in a tissue of a subject in need thereof. The methods can include contacting a microneedle array comprising a plurality of microneedles with a skin surface of the subject, wherein the plurality of microneedles comprises: i) a degradable hyaluronic acid polymer comprising a disulfide bond, and ii) a therapeutic agent; and applying pressure on the microneedle array such that the plurality of microneedles penetrates the skin surface, thereby releasing the therapeutic agent beneath the skin surface while simultaneously capturing ISF for successive analysis.
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公开(公告)号：WO2017044768A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050977
申请日：2016-09-09
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ARTZI, Natalie , CONDE, João , OLIVA, Nuria
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K47/595 , A61K47/61 , A61K47/6903 , C12N2310/113 , C12N2310/141 , C12N2310/15 , C12N2310/3515 , C12N2310/3517 , C12N2320/31 , C12N2320/32
Abstract: Provided herein are RNA triple helix structures. The RNA triple helix may be associated with a dendrimer to form an RNA triple helix-dendrimer conjugate, which may be applied to a biological tissue, such as a tumor. The RNA triple helix-dendrimer conjugate may be disposed in a hydrogel. The hydrogel may be applied to a biological tissue, such as a tumor. The hydrogel and/or dendrimer may control the release of the RNA triple helix. Methods of treating a biological tissue and kits also are provided.
Abstract translation: 本文提供了RNA三螺旋结构。 RNA三螺旋可以与树状聚合物缔合以形成RNA三螺旋 - 树枝状大分子缀合物，其可以应用于生物组织，例如肿瘤。 RNA三螺旋 - 树枝状大分子缀合物可以设置在水凝胶中。 水凝胶可以应用于诸如肿瘤的生物组织。 水凝胶和/或树枝状大分子可以控制RNA三螺旋的释放。 还提供了处理生物组织和试剂盒的方法。
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公开(公告)号：WO2012142470A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033604
申请日：2012-04-13
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARTZI, Natalie , EDELMAN, Elazer, R. , JORGE, Nuria, Oliva , SOLANES, Maria, Carcole
Inventor： ARTZI, Natalie , EDELMAN, Elazer, R. , JORGE, Nuria, Oliva , SOLANES, Maria, Carcole
CPC classification number: A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
Abstract translation: 提供生物相容的粘合剂材料，例如用于生物组织和/或医疗植入物，以及用于制备和使用生物相容性粘合剂材料的方法和试剂盒。 生物相容性粘合剂材料包括树枝状聚合物组分和聚合物组分，并且可以针对特定组织类型和条件而定制。
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Patent Agency Ranking
公开(公告)号：WO2022246093A1
公开(公告)日：2022-11-24
申请号：PCT/US2022/030078
申请日：2022-05-19
Inventor： ARTZI, Natalie , PONS, Pere, Dosta , CRYER, Alexander, M.
Abstract: A nanoparticle composition including: a first polymer conjugated to a drug by a linker to form a first polymer compound, the first polymer compound having a net negative charge; and a second polymer conjugated to at least one positively charged group to form a second polymer compound, the second polymer compound having a net positive charge, and the first polymer compound and the second polymer compound interacting electrostatically to form a nanoparticle.
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7.发明申请HYDROGEL PARTICLE OF CYSTAMINE CROSS-LINKED DEXTRAN ALDEHYDE CONTAINING IMINE CONJUGATED DOXORUBICIN AND RGD PEPTIDE FOR CHEMOTHERAPY 审中-公开半胱氨酸交联的含右旋糖酐的阿霉素含亚胺偶联的阿霉素和RGD肽化学治疗
公开(公告)号：WO2017201407A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033542
申请日：2017-05-19
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ARTZI, Natalie , OLIVA JORGE, Nuria , ZHANG, Yi , CONDE, Joao
IPC: C07D309/14 , A61K9/06 , A61K9/10 , A61K31/351 , A61K31/704 , A61K47/36 , A61P35/00
Abstract: A hydrogel particle comprising: cross-linked dextran aldehyde (oxidized dextran), comprising the redox sensitive disulfide cross-linker cystamine (2,2'-disulfanediyldiethanamine), the anti-tumor agent doxorubicin conjugated to the cross-linked polymer by a pH sensitive imine bond and the cell penetrating peptide RGD, for use in chemotherapy.
Abstract translation: 水凝胶颗粒包含：交联葡聚糖醛（氧化葡聚糖），其包含氧化还原敏感的二硫化物交联剂胱胺（2,2'-二硫烷二基二乙胺），抗肿瘤剂多柔比星与 交联聚合物通过pH敏感的亚胺键和细胞穿透肽RGD用于化学疗法。
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8.发明申请
公开(公告)号：WO2017196986A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031968
申请日：2017-05-10
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： EDELMAN, Elazer R. , ARTZI, Natalie , OLIVA, Nuria
IPC: A61K47/56
CPC classification number: A61K47/59 , A61K31/704 , A61K47/595 , A61K47/60 , A61K47/62 , A61K47/6903 , A61M5/19 , A61P35/00
Abstract: Abstract of the Disclosure Provided herein are compositions that include a dendrimer to which a drug and a binding peptide are conjugated. The binding peptide may be configured to bind to a receptor that is overexpressed by a diseased cell, such as a cancer cell. The compositions may include a hydrogel in which the dendrimer-drug conjugate is dispersed. Methods of drug delivery and kits also are provided.
Abstract translation: 本公开的摘要是包括药物和结合肽缀合于其上的树枝状聚合物的组合物。 结合肽可以被配置成结合由患病细胞（例如癌细胞）过表达的受体。 组合物可以包括其中分散有树状聚合物 - 药物缀合物的水凝胶。 还提供了药物递送方法和试剂盒。
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公开(公告)号：WO2017066516A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056967
申请日：2016-10-14
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： ARTZI, Natalie , EDELMAN, Elazer , UNTERMAN, Shimon Aryeh , CHARLES, Lyndon Fitzgerald , STRECKER, Sara Elaine
CPC classification number: A61L26/0052 , A61L24/0089 , A61L24/043 , A61L26/0004 , A61L26/0019 , A61L26/0057 , A61L26/0066 , A61L26/008 , A61L27/446 , A61L27/52 , A61L2400/06 , A61L2430/02 , A61L2430/06
Abstract: Provided herein are methods for treating, adhering, or sealing biological tissue with a material, such as a hydrogel, that may include phyllosilicate nanoplatelets. The phyllosilicate nanoplatelets can have a high aspect ratio, a low aspect ratio, or be a mixture of high aspect ratio and low aspect ratio nanoplatelets. Drug releasing compositions and kits also are provided herein.
Abstract translation: 本文提供了用可包含页硅酸盐纳米片的材料（例如水凝胶）处理，粘附或密封生物组织的方法。 页硅酸盐纳米片可以具有高纵横比，低纵横比，或者是高纵横比和低纵横比纳米片的混合物。 本文还提供了药物释放组合物和试剂盒。
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公开(公告)号：WO2022183122A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/018192
申请日：2022-02-28
Inventor： ARTZI, Natalie , DOSTA, Pere , PUIGMAL, Nuria
Abstract: The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond.
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