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公开(公告)号：WO2018175478A3
公开(公告)日：2018-09-27
申请号：PCT/US2018/023411
申请日：2018-03-20
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： GRIFFITH, Linda, G. , TRUMPER, David, L. , EDINGTON, Collin , ROHATGI, Gaurav , FREAKE, Duncan , SOENKSEN, Luis , KASSIS, Timothy , BHUSHAN, Brij, Mohan
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks with microbiome for an extended period of time of at least weeks and months. The platform has one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self- leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs together with microbiome in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology- based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the bioreactors is also provided.
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2.发明申请MODULAR ORGAN MICROPHYSIOLOGICAL SYSTEM WITH INTEGRATED PUMPING, LEVELING, AND SENSING 审中-公开集成泵送，调平和检测的模块化组织生物系统
公开(公告)号：WO2017176357A2
公开(公告)日：2017-10-12
申请号：PCT/US2017/016721
申请日：2017-02-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： GRIFFITH, Linda , TRUMPER, David, L. , EDINGTON, Collin, D. , ROHATGI, Gaurav , FREAKE, Duncan , SOENKSEN, Luis , BHUSHAN, Mohan, Brij
CPC classification number: C12M23/12 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2300/0829 , B01L2300/0887 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M25/14 , C12M29/10 , F04B19/006 , F04B23/04 , F04B23/06 , F04B43/043 , F04B43/12
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.
Abstract translation: 提供流体多孔生物反应器作为微生理学平台，用于多器官串联体的体外研究，持续至少数周和数月的持续时间。 所公开的平台具有对现有生物反应器的一个或多个改进，包括用于气动驱动的流体流动的板载泵送，用于从源到下自流平的重新设计的溢流道，非接触式内置流体液位感测装置，精确的 控制流体流动剖面和分区，以及简单的重新配置，如菊花链和多层堆叠。 该平台支持微生理学相互作用系统中多种器官的培养，适用于广泛的生物医学应用，包括全身毒性研究和基于生理学的药代动力学和药效学预测。 还提供了制造所公开的生物反应器的过程。
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公开(公告)号：WO2018175478A2
公开(公告)日：2018-09-27
申请号：PCT/US2018/023411
申请日：2018-03-20
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： GRIFFITH, Linda, G. , TRUMPER, David, L. , EDINGTON, Collin , ROHATGI, Gaurav , FREAKE, Duncan , SOENKSEN, Luis , KASSIS, Timothy , BHUSHAN, Brij, Mohan
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01J2219/00182 , B01J2219/00306 , B01J2219/00355 , B01J2219/00479 , B01J2219/00889 , B01J2219/00952 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2300/0829 , B01L2300/0887 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , C12M23/04 , C12M23/16 , C12M23/42 , F04B19/006 , F04B23/06 , F04B43/043 , F04B43/12 , G01F23/263
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks with microbiome for an extended period of time of at least weeks and months. The platform has one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self- leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs together with microbiome in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology- based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the bioreactors is also provided.
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4.发明申请
公开(公告)号：WO2017176357A3
公开(公告)日：2017-10-12
申请号：PCT/US2017/016721
申请日：2017-02-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： GRIFFITH, Linda , TRUMPER, David, L. , EDINGTON, Collin, D. , ROHATGI, Gaurav , FREAKE, Duncan , SOENKSEN, Luis , BHUSHAN, Mohan, Brij
IPC: B01L3/00
Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.
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