公开(公告)号：WO2009149367A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/046437

申请日：2009-06-05

Applicant: MEDRAD, INC. ,  UBER, Arthur, E., III ,  TROCKI, Mark ,  MABIE, Marc, A. ,  MCCUTCHAN, Larry ,  SIDDOWAY, L., George ,  COWAN, Kevin, P. ,  COATES, Lisa, M. ,  KALAFUT, John, F. ,  HUGHES, Aaron ,  GRIFFITHS, David, M. ,  TWICHELL, Peter ,  GULICK, Julie ,  TROMBLEY, Frederick, W., III

Inventor： UBER, Arthur, E., III ,  TROCKI, Mark ,  MABIE, Marc, A. ,  MCCUTCHAN, Larry ,  SIDDOWAY, L., George ,  COWAN, Kevin, P. ,  COATES, Lisa, M. ,  KALAFUT, John, F. ,  HUGHES, Aaron ,  GRIFFITHS, David, M. ,  TWICHELL, Peter ,  GULICK, Julie ,  TROMBLEY, Frederick, W., III

IPC: E03B11/00

CPC classification number: A61N5/1007 ,  A61M5/007 ,  A61M5/16827 ,  A61M5/1785 ,  A61M2005/1402 ,  A61M2202/0225 ,  A61M2202/049 ,  A61M2206/11 ,  A61M2206/18 ,  Y10T137/0318

Abstract: A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.

Abstract translation: 公开了一种危险流体输送容器和危险流体输送系统。 危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。 第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。 可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。 此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。 此外，公开了一种用于注射器或其他容器的放射性流体输送容器。 放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

公开(公告)号：WO2002070049A1

公开(公告)日：2002-09-12

申请号：PCT/US2002/003210

申请日：2002-02-04

Applicant: MEDRAD, INC.

Inventor： REILLY, David, M. ,  TROMBLEY, Frederick, W., III ,  TROCKI, Mark

IPC: A61M5/145

CPC classification number: A61M5/31581 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/31593 ,  A61M5/31595

Abstract: A syringe loading/filling device (5) (or "syringe Loader") includes a syringe mounting mechanism (22a, 22b) adapted to cooperate with an attachment mechanism of a syringe (20) to attach the syringe to the syringe loader and a drive member adapted to impart motion to the syringe plunger (40). The syringes for use with the syringe loader include a syringe plunger (40) slidably disposed therein and an attachment mechanism (66a, 66b) for attachment of the syringe (20) to an injector (10). Such injectors include a mounting mechanism adapted to cooperate with the attachment mechanism on the syringe to mount the syringe (20) on the injector.

Abstract translation: 注射器装载/填充装置（5）（或“注射器装载机”）包括适于与注射器（20）的附接机构配合以将注射器附接到注射器装载器的驱动器的注射器安装机构（22a，22b） 适于将动作赋予注射器柱塞（40）的构件。 用于注射器装载器的注射器包括可滑动地设置在其中的注射器柱塞（40）和用于将注射器（20）附接到注射器（10）的附接机构（66a，66b）。 这种注射器包括适于与注射器上的附接机构配合以将注射器（20）安装在注射器上的安装机构。

公开(公告)号：WO2007053779A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/043134

申请日：2006-11-06

Applicant: MEDRAD, INC. ,  UBER, Arthur, E., III ,  TROMBLEY, Frederick, W., III ,  GELBLUM, Eugene, A. ,  RHINEHART, Edward, J. ,  REILLY, David, M. ,  CEDARHOLM, Page ,  COWAN, Kevin, P. ,  TROCKI, Mark ,  HIRSCHMAN, Alan, D.

Inventor： UBER, Arthur, E., III ,  TROMBLEY, Frederick, W., III ,  GELBLUM, Eugene, A. ,  RHINEHART, Edward, J. ,  REILLY, David, M. ,  CEDARHOLM, Page ,  COWAN, Kevin, P. ,  TROCKI, Mark ,  HIRSCHMAN, Alan, D.

IPC: A61M31/00 ,  A01N1/02 ,  C12M1/12 ,  C12M1/24 ,  B65D25/04 ,  A01N1/00 ,  C12M3/00 ,  B65D1/24

CPC classification number: A61J1/1443 ,  A61J1/1456 ,  A61J1/1475 ,  A61M5/142 ,  A61M5/1723 ,  A61M5/3145 ,  A61M31/005 ,  B01L3/502 ,  B01L2300/044 ,  B01L2300/0681 ,  G06F19/3468

Abstract: A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract translation: 用于将注射器注射到患者体内的系统包括用于保持注射器的第一可加压容器; 与所述第一可加压容器流体连接的患者接口，所述患者接口适于将所述注射器通入患者的组织; 动力注射器，其与所述第一可加压容器可操作地连接以对所述注射器加压; 与动力注射器操作连接的控制器系统; 以及适于与病人界面操作连接的立体定向定位框架，以协助控制患者界面的定位。 用于处理细胞（和/或其它注射组分）的系统​​包括适于可滑动地定位在容器内的容器和柱塞。 该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。 柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于通过入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物 港口。

公开(公告)号：WO2005110007A2

公开(公告)日：2005-11-24

申请号：PCT/US2004/011190

申请日：2004-04-12

Applicant: MEDRAD, INC.

Inventor： TROMBLEY, Frederick, W., III ,  SCHMIDT, Robert, M. ,  REILLY, David, M. ,  HIRSCHMAN, Alan, D. ,  GRIFFITHS, David, M. ,  CALLAN, Gerald, W. ,  PEDRAZA, Luis, A. ,  KWO, Jennie ,  ZIRPS, Christopher, T. ,  BEAULIEU, Roderick, H.

IPC: A61M5/00 ,  A61M5/14 ,  A61M5/145 ,  A61M5/168 ,  A61M5/36 ,  A61M39/22 ,  A61M39/24

CPC classification number: A61M5/007 ,  A61M5/14546 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/36 ,  A61M39/22 ,  A61M39/223 ,  A61M39/24 ,  A61M2005/1403 ,  A61M2205/3331 ,  A61M2205/582

Abstract: An injector system includes a source of injection fluid, a pump device, a fluid path set disposed between the source of injection fluid and the pump device, and a fluid control device operatively associated with the fluid path set. The fluid control device is adapted to permit purging of air from the fluid path set and to stop flow of the injection fluid to a patient at substantially any pressure or flow rate generated by the pump device for delivering a sharp bolus of the injection fluid to the patient. The fluid control device is preferably part of the fluid path set between the source of injection fluid and the pump device. In another aspect, an injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injector, a fluid path in fluid connection with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection with the fluid path. A pressure isolation mechanism for use in a medical procedure includes a lumen, an isolation port in fluid connection with the lumen, and a valve having a first state and a second state. The first state occurs when the lumen and the isolation port are connected. The second state occurs when the lumen and the isolation port are disconnected. The lumen remains open for flow of fluid therethrough in the first state and in the second state. The valve is normally in the first state and is switchable to the second state when fluid pressure in the lumen reaches a predetermined pressure level. A pressure transducer can be in fluid connection with the isolation port of the pressure isolation mechanism. A fluid delivery system includes a manually operated syringe and a pressure isolation mechanism as described above.

Abstract translation: 注射器系统包括注射流体源，泵装置，设置在注射流体源和泵装置之间的流体路径组以及与流体路径组可操作地相关联的流体控制装置。 流体控制装置适于允许从流体路径组清洗空气并且以基本上由泵装置产生的任何压力或流速停止注射流体到患者的流动，用于将喷射流体的尖锐推注物输送到 患者。 流体控制装置优选地是在注射流体源和泵装置之间设置的流体路径的一部分。 在另一方面，喷射器系统包括动力注射器，与动力注射器可操作地连接的加压室，与加压室流体连接的流体路径，以及与流体路径流体连接的手动控制。 手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。 致动器通过与流体路径的流体连接提供到操作者的流体路径中的压力的​​触觉反馈。 用于医疗过程的压力隔离机构包括管腔，与内腔流体连接的隔离口以及具有第一状态和第二状态的阀。 当管腔和隔离口连接时，发生第一种状态。 当管腔和隔离端口断开时，发生第二种状态。 在第一状态和第二状态下，内腔保持打开以使流体流过其中。 阀通常处于第一状态，并且当内腔中的流体压力达到预定压力水平时可切换到第二状态。 压力传感器可以与压力隔离机构的隔离端口流体连接。 流体输送系统包括手动操作的注射器和如上所述的压力隔离机构。

公开(公告)号：WO2003006101A2

公开(公告)日：2003-01-23

申请号：PCT/US2002/021482

申请日：2002-07-03

Applicant: MEDRAD, INC.

Inventor： TROMBLEY, Frederick, W., III ,  SCIULLI, Francis, J. ,  GRIFFITHS, David, M. ,  TROCKI, Mark ,  UBER, Arthur, E., III

IPC: A61M39/08

CPC classification number: A61M5/142 ,  A61M39/08 ,  A61M39/10

Abstract: A tubing set inludes a length of tubing having at least a section thereof that is fabricated to function with an infusion pump. The tubing set further preferably includes a first valve that is removably connected to the length of tubing on a first end thereof. The first valve is preferably in a closed state when disconnected from the length of tubing. The tubing set also preferably includes a second valve on a second end thereof. The second valve is preferably in a closed state until connected to another fluid path component. The tubing set is preferably suitable for use in an MR environment. A method of replacing at least a first infusion pump in connection with a patient with at least a second infusion pump includes the steps: closing a length of patient tubing connected to a patient to prevent blackflow of blood therethrough, the patient tubing being in fluid communication at a first end thereof with a length of administration tubing, the administration tubing being in operative connection with the first infusion pump and being in fluid connection with a source of fluid, the patient tubing being in fluid connection with a patient catheter at a second end thereof; disconnecting the patient tubing from the administration tubing; connnecting an intermediate length of tubing to the administration tubing, the intermediate tubing including at least a section thereof that is fabricated to function with the second infusion pump; placing the second infusion pump in operative connection with the intermediate tubing; removing the first infusion pump from operative connection with the administration tubing; and connecting the intermediate tubing to the patient tubing.

Abstract translation: 管组包括具有至少其一部分的管的长度，其被制造成与输注泵一起起作用。 管组还优选地包括第一阀，其可拆卸地连接到其第一端上的管道长度。 当与管道的长度断开时，第一阀优选处于关闭状态。 管组还优选地包括在其第二端上的第二阀。 第二阀优选地处于关闭状态，直到连接到另一个流体路径部件。 管组优选适用于MR环境。 用至少第二输液泵替代与患者相关的至少第一输注泵的方法包括以下步骤：闭合连接到患者的一段长度的患者管线，以防止血液从其中流过，患者管路处于流体连通状态 在其第一端具有一定长度的给药管，所述给药管与所述第一输注泵可操作地连接并且与流体源流体连接，所述患者管与第二端的患者导管流体连接 物; 从患者管路断开患者管路; 将中间长度的管道连接到所述管理管道，所述中间管道包括制造成与所述第二输注泵一起起作用的至少一部分; 将所述第二输液泵放置成与所述中间管道有效连接; 将所述第一输注泵从所述管道管的操作连接中移除; 并将中间管连接到患者管。

公开(公告)号：WO2003006101A3

公开(公告)日：2003-01-23

申请号：PCT/US2002/021482

申请日：2002-07-03

Applicant: MEDRAD, INC.

Inventor： TROMBLEY, Frederick, W., III ,  SCIULLI, Francis, J. ,  GRIFFITHS, David, M. ,  TROCKI, Mark ,  UBER, Arthur, E., III

IPC: A61M39/08

Abstract: A tubing set inludes a length of tubing having at least a section thereof that is fabricated to function with an infusion pump. The tubing set further preferably includes a first valve that is removably connected to the length of tubing on a first end thereof. The first valve is preferably in a closed state when disconnected from the length of tubing. The tubing set also preferably includes a second valve on a second end thereof. The second valve is preferably in a closed state until connected to another fluid path component. The tubing set is preferably suitable for use in an MR environment. A method of replacing at least a first infusion pump in connection with a patient with at least a second infusion pump includes the steps: closing a length of patient tubing connected to a patient to prevent blackflow of blood therethrough, the patient tubing being in fluid communication at a first end thereof with a length of administration tubing, the administration tubing being in operative connection with the first infusion pump and being in fluid connection with a source of fluid, the patient tubing being in fluid connection with a patient catheter at a second end thereof; disconnecting the patient tubing from the administration tubing; connnecting an intermediate length of tubing to the administration tubing, the intermediate tubing including at least a section thereof that is fabricated to function with the second infusion pump; placing the second infusion pump in operative connection with the intermediate tubing; removing the first infusion pump from operative connection with the administration tubing; and connecting the intermediate tubing to the patient tubing.

公开(公告)号：WO2002066100A2

公开(公告)日：2002-08-29

申请号：PCT/US2002/004827

申请日：2002-02-20

Applicant: MEDRAD, INC.

Inventor： COWAN, Kevin, P. ,  HITCHINS, Mark, W. ,  BISEGNA, Joseph, E. ,  MCFALL, Frank, B. ,  TROMBLEY, Frederick, W., III ,  GRUBIC, Herbert, M. ,  REILLY, David, M. ,  UBER, Arthur, E., III ,  SCIULLI, Francis, J. ,  SCHRIVER, Ralph, H.

IPC: A61M3/00

CPC classification number: A61M39/1011 ,  A61M2039/1033 ,  A61M2039/1044

Abstract: A syringe for use in a medical injection procedure in connection with connectors having a tapered fitting includes a syringe tip having a cooperating tapered fitting including a passage therein in fluid communication with an interior of the syringe. The syringe also includes a first connecting member having a radially inward threaded portion on an inner surface thereof adapted to connect to a first type of connector including a tapered fitting having at least one radially outward extending flange adapted to connect to the radially inward threaded portion of the first connecting member. In that regard, the first connecting member allows connection of the syringe to, for example, a standard luer fitting connector. The syringe further includes a second connecting member having at least one attachment member such as a radially outward extending flange adapted to connect to a second type of connector which includes a tapered fitting and a cooperating attachment member to engage the at least one attachment member of the second connecting member. The second connecting member allows connection of the syringe to improved tapered fitting connectors described herein.

Abstract translation: 用于与具有锥形配件的连接器相关的医疗注射程序的注射器包括具有配合的锥形配件的注射器末端，其包括与注射器的内部流体连通的通道。 注射器还包括第一连接构件，其内表面上具有径向向内的螺纹部分，其适于连接到第一类型的连接器，该第一连接器包括具有至少一个径向向外延伸的凸缘的锥形配件，该凸缘适于连接到径向向内螺纹部分 第一连接构件。 在这方面，第一连接构件允许注射器连接到例如标准鲁尔接头连接器。 注射器还包括第二连接构件，其具有至少一个附接构件，例如径向向外延伸的凸缘，其适于连接到第二类型的连接器，该第二类型的连接器包括锥形配件和配合的附接构件，以与所述至少一个连接构件 第二连接构件。 第二连接构件允许注射器连接到本文所述的改进的锥形配合连接器。

公开(公告)号：WO1994022520A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003618

申请日：1994-04-01

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  TROMBLEY, Frederick, W., III ,  DEDOLA, Salvatore, J.

IPC: A61M25/00

CPC classification number: A61M39/10 ,  A61M2039/1033 ,  A61M2039/1044 ,  Y10S604/905

Abstract: A luer connector (10) is provided with a tactile and audible torque indicator. The indicator comprises a detent incorporated between the female cylindrical component (14) of the luer connector and a rotatable collar (32) mounted thereon. As the collar (32) is turned in a clockwise direction, the collar is impeded by the detent formed by opposingly projecting protuberances (34, 38) between the inside of the collar and the outside of the female cylindrical luer component (14). As the threaded luer connection is tightened, requiring additional torque to tighten it further, the additional torque overcomes the resistance of the detent, allowing the collar protuberance to slip past the cylinder protuberance. The female luer component may also be provided with a color patch or pattern (40), to indicate by its rotation, when the detent has been overcome, that the luer connection has been appropriately tightened.

Abstract translation: 路厄连接器（10）设置有触觉和听觉扭矩指示器。 指示器包括结合在路厄尔连接器的阴圆柱形部件（14）和安装在其上的可旋转轴环（32）之间的制动器。 当套环（32）沿顺时针方向转动时，套环由在套环的内部和阴圆柱形路厄器件（14）的外侧之间相对突出的突起（34,38）形成的制动器阻碍。 当螺纹鲁尔连接被拧紧时，需要额外的扭矩来进一步拧紧，额外的扭矩克服了制动器的阻力，允许轴环凸起滑过气缸凸起。 阴路厄部件还可以设置有色块或图案（40），以通过其旋转来指示当制动器已被克服时，鲁尔连接已被适当地拧紧。