公开(公告)号：WO2009120435A1

公开(公告)日：2009-10-01

申请号：PCT/US2009/034859

申请日：2009-02-23

Applicant: MEDTRONIC, INC. ,  FRANCISCHELLI, David E. ,  STEWART, Mark T. ,  CHEEK, Daniel S. ,  ROSS, Brian J. ,  HAMEED, Asif ,  ROTHSTEIN, Paul T. ,  BATCHELOR, Kester J. ,  COLON, William ,  KLEIN, Scott T. ,  CROWE, Douglas A.

Inventor： FRANCISCHELLI, David E. ,  STEWART, Mark T. ,  CHEEK, Daniel S. ,  ROSS, Brian J. ,  HAMEED, Asif ,  ROTHSTEIN, Paul T. ,  BATCHELOR, Kester J. ,  COLON, William ,  KLEIN, Scott T. ,  CROWE, Douglas A.

IPC: A61B18/14 ,  A61N1/37

CPC classification number: A61B18/1402 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2017/00053 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1472 ,  A61N1/06 ,  A61N1/36017

Abstract: A system for ablating tissue and electrically interfacing with a heart including an electrosurgical instrument, an energy source, and a controller. The instrument includes a shaft maintaining first and second electrodes at a distal section. The electrodes are electrically isolated from one another. The controller controls delivery of energy from the energy source, and monitors electrical signals at the electrodes. The controller is programmed to operate in a monopolar mode and a bipolar mode. In the monopolar mode, the first and second electrodes are electrically uncoupled, and energy from the energy source is delivered to the first electrode in performing an ablation procedure. In the bipolar mode, first and second electrodes are electrically coupled and serve as opposite polarity poles to apply energy to a tissue target site, detect electrical signals at a tissue target site, or both.

Abstract translation: 一种用于消融组织并与包括电外科器械，能量源和控制器的心脏电接口的系统。 仪器包括轴，其在远端部分保持第一和第二电极。 电极彼此电隔离。 控制器控制能量从能源的传递，并监测电极处的电信号。 控制器被编程为在单极模式和双极模式下工作。 在单极模式中，第一和第二电极是电耦合的，并且来自能量源的能量在执行消融过程时被传送到第一电极。 在双极模式中，第一和第二电极被电耦合并且用作相反的极性极以将能量施加到组织靶位点，检测组织靶位置处的电信号，或者两者。

公开(公告)号：WO2011106240A1

公开(公告)日：2011-09-01

申请号：PCT/US2011/025309

申请日：2011-02-17

Applicant: MEDTRONIC INC. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E.

Inventor： STEWART, Mark T. ,  FRANCISCHELLI, David E.

IPC: A61B18/14

CPC classification number: A61N7/02 ,  A61B8/485 ,  A61B8/5223 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61N2007/0065 ,  A61N2007/0095 ,  A61N2007/027

Abstract: Device, system and method for evaluating the effectiveness of tissue ablations of a heart of a patient. The tissue is clamped between a pair of opposing jaws. A portion of the tissue is ablated at a first generally linear position on the tissue by applying ablative energy to two of a plurality of elongate electrodes, each of the two of the plurality of elongate electrodes being coupled in opposing relationship to each other and the pair of opposing jaws, respectively. An effectiveness of the ablation is sensed at a second generally linear position on the tissue with at least one of the plurality of elongate electrodes positioned on one of the pair of opposing jaws. The second linear position on the tissue is laterally distal to the first linear position on the tissue with respect to the atrium of the heart.

Abstract translation: 用于评估患者心脏组织消融有效性的装置，系统和方法。 将组织夹在一对相对的夹爪之间。 通过向多个细长电极中的两个施加烧蚀能量，组织的一部分在组织上的第一大致线性位置被消融，多个细长电极中的每一个彼此相对地相互耦合，并且该对 的对颚分别。 在组织上的第二大致直线位置处感测消融的有效性，其中多个细长电极中的至少一个位于一对相对的夹爪中的一个上。 组织上的第二线性位置相对于心脏的心房横向远离组织上的第一线性位置。

公开(公告)号：WO2007127664A1

公开(公告)日：2007-11-08

申请号：PCT/US2007/066952

申请日：2007-04-19

Applicant: MEDTRONIC, INC. ,  PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

Inventor： PLOTT, Christopher J. ,  OLSON, Andrew L. ,  CLOUTIER, Patrick J. ,  SMITH, Christopher W. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E. ,  BRISCOE, Roderick E. ,  HAEG, Daniel C. ,  KIM, David J.S. ,  HOBDAY, Michael J. ,  KANAYINKAL, Tessy ,  GUBBIN, Douglas H. ,  ROTHSTEIN, Paul T. ,  CARDINAL, Joseph E. ,  FOLEY, Jessica L. ,  LEUER, Leonard H. ,  DAIGLE, Thomas P.

IPC: A61B17/12 ,  A61B17/128 ,  A61B17/00

CPC classification number: A61B17/12009 ,  A61B17/12013 ,  A61B17/1285 ,  A61B2017/00243 ,  A61B2017/00296 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00632 ,  A61B2017/12018

Abstract: Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.

Abstract translation: 本发明的一些实施例提供一种用于闭塞患者的左心耳的系统。 该系统的一些实施例可以包括可以围绕左心耳定位的环形阻塞器和环形施放器，以相对于左心耳定位环形闭塞器。 一个实施例公开了通过心房附近获得心脏心内膜表面的方法。 本发明的另外的实施例提供了可围绕左心耳定位的夹子封堵器。 夹子施放器可以相对于左心耳定位夹子封堵器。

公开(公告)号：WO2011094073A2

公开(公告)日：2011-08-04

申请号：PCT/US2011/021227

申请日：2011-01-14

Applicant: MEDTRONIC, INC. ,  URBAN, Jon F. ,  SHARMA, Vinod ,  STEWART, Mark T.

Inventor： URBAN, Jon F. ,  SHARMA, Vinod ,  STEWART, Mark T.

IPC: A61N1/05

CPC classification number: A61N1/0575 ,  A61B5/042 ,  A61B5/6848 ,  A61B5/6852 ,  A61B2017/00053 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0091

Abstract: A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.

Abstract translation: 系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。 该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

公开(公告)号：WO2011136867A1

公开(公告)日：2011-11-03

申请号：PCT/US2011/026007

申请日：2011-02-24

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  WERNETH, Randell L. ,  SHERMAN, Marshall L. ,  STEWART, Mark T. ,  FLAHERTY, J. Christopher

Inventor： WERNETH, Randell L. ,  SHERMAN, Marshall L. ,  STEWART, Mark T. ,  FLAHERTY, J. Christopher

IPC: A61B5/06 ,  A61B18/00 ,  A61B5/053 ,  A61B19/00 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/08 ,  A61B5/103

CPC classification number: A61B18/1492 ,  A61B5/01 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/063 ,  A61B5/08 ,  A61B5/103 ,  A61B5/6885 ,  A61B5/7207 ,  A61B5/743 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/24 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0262 ,  A61B2034/2046 ,  A61B2090/065 ,  G06F19/00

Abstract: A medical method is provided, including a medical device having a distal assembly including at least one electrode and at least one treatment element, the medical device generating information regarding at least one of a physiological measurement and an operational parameter of the medical device; a plurality of surface electrodes affixable to a skin of the patient, wherein the surface electrodes are in electrical communication with the distal assembly to obtain position information of the medical device; and a processor pairing the position information and the at least one of a physiological measurement and an operational parameter of the medical device.

Abstract translation: 提供了一种医疗方法，包括具有包括至少一个电极和至少一个治疗元件的远端组件的医疗装置，所述医疗装置产生关于所述医疗装置的生理测量和操作参数中的至少一个的信息; 多个表面电极可固定在患者皮肤上，其中表面电极与远端组件电连通以获得医疗装置的位置信息; 以及将所述位置信息和所述医疗装置的生理测量和操作参数中的至少一个配对的处理器。

公开(公告)号：WO2012106100A2

公开(公告)日：2012-08-09

申请号：PCT/US2012/021478

申请日：2012-01-17

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  SHERMAN, Marshall L. ,  CONDIE, Catherine R. ,  STEWART, Mark T.

Inventor： SHERMAN, Marshall L. ,  CONDIE, Catherine R. ,  STEWART, Mark T.

IPC: A61B18/12

CPC classification number: A61B5/0531 ,  A61B5/0536 ,  A61B5/4848 ,  A61B5/7246 ,  A61B18/02 ,  A61B18/12 ,  A61B18/1492 ,  A61B2017/00128 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00666 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/0212

Abstract: A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.

Abstract translation: 一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用所述医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

公开(公告)号：WO2013019378A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/046479

申请日：2012-07-12

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  HONECK, Jordon D.

Inventor： STEWART, Mark T. ,  HONECK, Jordon D.

IPC: A61B18/02 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00994 ,  A61B2018/0212 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2018/1437

Abstract: A medical system, including a catheter body, an elongate body disposed in the catheter body; an expandable element having a proximal portion coupled to the catheter body and a distal portion coupled to the elongate body, the distal portion of the expandable element defining the distal-most portion of the medical device; a mesh or array of longitudinal splines substantially surrounding the expandable element, at least a portion of the mesh or splines being electrically conductive; and a coolant source in fluid communication with the expandable element.

Abstract translation: 医疗系统，包括导管主体，设置在导管主体中的细长主体; 可扩张元件，其具有联接到导管主体的近端部分和联接到细长主体的远端部分，可扩张元件的远端部分限定医疗装置的最远部分; 基本上围绕所述可膨胀元件的纵向花键的网状物或阵列，所述网状物或花键的至少一部分是导电的; 以及与可膨胀元件流体连通的冷却剂源。

公开(公告)号：WO2012142197A1

公开(公告)日：2012-10-18

申请号：PCT/US2012/033171

申请日：2012-04-12

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  DAVIE, Scott W. ,  DESROCHERS, Giles

Inventor： STEWART, Mark T. ,  DAVIE, Scott W. ,  DESROCHERS, Giles

IPC: A61B5/0408 ,  A61B5/042 ,  A61B5/00

CPC classification number: A61B5/743 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/0422 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/6852 ,  A61B6/12 ,  A61B6/503 ,  A61B8/0841 ,  A61B8/0883

Abstract: A method of mapping electrophysiological information, including receiving imaging information for a tissue region; receiving a monophasic action potential signal from the tissue region; assigning a value corresponding to a depolarization segment of the monophasic action potential signal; receiving location information associated with the monophasic action potential signal; and generating an image based on the imaging information, the assigned value, and the location information.

Abstract translation: 一种映射电生理信息的方法，包括接收组织区域的成像信息; 从所述组织区域接收单相动作电位信号; 分配与单相动作电位信号的去极化部分对应的值; 接收与单相动作电位信号相关联的位置信息; 以及基于成像信息，分配值和位置信息生成图像。

公开(公告)号：WO2013019385A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/046617

申请日：2012-07-13

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  HONECK, Jordon D.

Inventor： STEWART, Mark T. ,  HONECK, Jordon D.

IPC: A61B18/14 ,  A61N1/32

CPC classification number: A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00613 ,  A61B2018/1435 ,  A61N1/327

Abstract: A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.

Abstract translation: 一种医疗系统，包括具有多个可展开臂的医疗装置，以及至少一个所述多个臂中的至少一个上的至少一个电极; 以及与该医疗装置通信的电信号发生器，该电信号发生器被编程为将脉冲能量传送到医疗装置，足以引起不可逆电穿孔消融。

公开(公告)号：WO2012121882A1

公开(公告)日：2012-09-13

申请号：PCT/US2012/026042

申请日：2012-02-22

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

Inventor： WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

IPC: A61B5/042 ,  A61N1/05 ,  A61B18/14

CPC classification number: A61B5/0422 ,  A61B18/1492 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

Abstract: A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.

Abstract translation: 一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。 控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。