公开(公告)号：WO2018200189A1

公开(公告)日：2018-11-01

申请号：PCT/US2018/026857

申请日：2018-04-10

Applicant: MEDTRONIC VASCULAR, INC.

Inventor： ARGENTINE, Jeffery

IPC: A61F2/966 ,  A61F2/95

Abstract: A delivery system for delivering a prosthesis includes a housing, a sheath extending from within the housing, a first rotatable knob, a first pulley coupled to the first rotatable knob so as to be rotatable therewith, a second rotatable knob, a second pulley coupled to the second rotatable knob so as to be rotatable therewith, and a cable coupled to the first pulley and to the second pulley. The cable is coupled to a proximal portion of the sheath. Rotation of the first rotatable knob causes the first pulley to rotate while the second pulley remains stationary thereby causing the first pulley to wind up a portion of the cable and retract the sheath at a first speed. Rotation of the second rotatable knob causes both the first and second pulleys to rotate, thereby causing both the first and second pulleys to wind up a portion of the cable and retract the sheath at a second speed being faster than the first speed.

公开(公告)号：WO2017139545A1

公开(公告)日：2017-08-17

申请号：PCT/US2017/017327

申请日：2017-02-10

Applicant: MEDTRONIC VASCULAR INC.

Inventor： PERKINS, Keith ,  ARGENTINE, Jeffery ,  PETRUSKA, Matt ,  ROBAINA, Samuel ,  GALLIGAN, Darren ,  RADHAKRISHNAN, Rajesh

IPC: A61F2/07 ,  A61F2/00

CPC classification number: A61F2/07 ,  A61F2/0077 ,  A61F2002/065 ,  A61F2002/068 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2210/0061 ,  A61F2230/0065 ,  A61F2250/0051 ,  A61F2250/0056 ,  A61F2310/00023

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract translation: 脚手架支架移植物包括具有内表面和外表面的移植物材料。 内表面限定移植物材料内的内腔。 脚手架覆膜支架还包括支架，该支架包括在外表面处与移植物材料偶联的网。 支架构造成促进其中的组织向内生长。 以这种方式，支架增强组织整合到脚手架支架 - 移植物中。 组织整合增强了支架支架移植物在血管中的生物固定，从而最大限度地减少了内漏和迁移的可能性。

公开(公告)号：WO2016200964A1

公开(公告)日：2016-12-15

申请号：PCT/US2016/036475

申请日：2016-06-08

Applicant: MEDTRONIC VASCULAR INC.

Inventor： GALLIGAN, Darren ,  ARGENTINE, Jeffery ,  MORRIS, Benjamin

IPC: A61B17/04

CPC classification number: A61B17/0467 ,  A61B17/0482 ,  A61B17/0487 ,  A61B2017/00659 ,  A61B2017/00663 ,  A61B2017/0488

Abstract: A system for forming a suture connector in situ includes a suture connector placement device having a handle, an outer shaft, an intermediate shaft, and a push rod, and a suture connector having a sleeve and a plug. The intermediate shaft is slidingly disposed through a lumen of the outer shaft, and the push rod is slidingly disposed through a lumen of the intermediate shaft. When the suture connector is in a loaded configuration within the suture connector placement device, the sleeve is radially disposed over the intermediate shaft and the plug is positioned proximal to the sleeve within the lumen of the intermediate shaft. Distal advancement of the push rod moves the plug into the sleeve and proximal retraction of the intermediate shaft releases the resilient sleeve onto the plug, thereby securing two suture portions between the sleeve and the plug. The system is then utilized to trim the suture portions.

Abstract translation: 用于原位形成缝合连接器的系统包括具有手柄，外轴，中间轴和推杆的缝合线连接器放置装置，以及具有套筒和塞子的缝合连接器。 中间轴通过外轴的内腔滑动地设置，并且推杆通过中间轴的内腔滑动设置。 当缝合连接器处于缝合连接器放置装置内的装载构造中时，套筒径向地设置在中间轴上方，并且插头位于中间轴的内腔内的套筒的近侧。 推杆的远端推进将插头移动到套筒中，并且中间轴的近端缩回将弹性套筒释放到插头上，从而将两个缝合部分固定在套筒和插头之间。 然后将该系统用于修剪缝合部分。

公开(公告)号：WO2015122987A1

公开(公告)日：2015-08-20

申请号：PCT/US2015/011519

申请日：2015-01-15

Applicant: MEDTRONIC VASCULAR INC.

Inventor： ARGENTINE, Jeffery

IPC: A61B17/04

CPC classification number: A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B2017/00862 ,  A61B2017/0409 ,  A61B2017/0488

Abstract: A system (400) for forming a suture connector in situ includes a suture connector placement device having a handle (450), an outer shaft (464), an intermediate shaft (474), and a push rod (482), and a suture connector having a sleeve (406) and a plug (408). The intermediate shaft is slidingly disposed through a lumen of the outer shaft, and the push rod is slidingly disposed through a lumen of the intermediate shaft. When the suture connector is in a loaded configuration within the suture connector placement device, the sleeve is radially disposed between the intermediate shaft and the outer shaft and the plug is positioned proximal to the sleeve within the lumen of the intermediate shaft. Distal advancement of the push rod moves the plug into the sleeve and proximal retraction of the intermediate shaft releases the resilient sleeve onto the plug, thereby securing two suture portions between the sleeve and the plug.

Abstract translation: 一种用于原位形成缝线连接器的系统（400）包括具有手柄（450），外轴（464），中间轴（474）和推杆（482）的缝线连接器放置装置，以及缝线 连接器具有套筒（406）和插头（408）。 中间轴通过外轴的内腔滑动地设置，并且推杆通过中间轴的内腔滑动设置。 当缝线连接器处于缝合连接器放置装置内的装载构造中时，套筒径向地设置在中间轴和外部轴之间，并且插头位于中间轴的内腔内的套筒的近侧。 推杆的远端推进将插头移动到套筒中，并且中间轴的近端缩回将弹性套筒释放到插头上，从而将两个缝合部分固定在套筒和插头之间。

公开(公告)号：WO2013162688A1

公开(公告)日：2013-10-31

申请号：PCT/US2013/026738

申请日：2013-02-19

Applicant: MEDTRONIC VASCULAR INC.

Inventor： ARGENTINE, Jeffery ,  HAGGARD, Mathew ,  MAGGARD, Jason ,  SIMMONS, Emilie

IPC: A61F2/966

CPC classification number: A61F2/966 ,  A61F2/954 ,  A61F2002/061 ,  A61F2002/067 ,  A61F2002/9517 ,  A61F2250/006

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract translation: 公开了一种可重新配置的输送系统，其具有多腔输送导管配置，其允许自扩张主血管支架移植物的递送和分期释放以及允许引入用于输送和植入的各种医疗装置的输送护套构造 与主血管支架移植物配对的各种分支血管支架移植物。 公开了一种方法，其中所述递送系统首先用于多腔输送导管构型以递送和释放被配置用于放置在腹主动脉中的主血管支架移植物，用于治疗短颈肾上，近肾和/ 或肾上动脉瘤，然后用于输送鞘结构，以促进分支血管支架移植物的输送，其构造成从主血管支架移植物延伸到相应的肾动脉中。

公开(公告)号：WO2015047654A1

公开(公告)日：2015-04-02

申请号：PCT/US2014/053283

申请日：2014-08-28

Applicant: MEDTRONIC VASCULAR INC.

Inventor： GALLIGAN, Darren ,  ARGENTINE, Jeffery

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/062

CPC classification number: A61B17/0057 ,  A61B17/0483 ,  A61B17/062 ,  A61B2017/00663 ,  A61B2017/0472

Abstract: A suturing device includes a handle, an elongated body, at least one suture snag, at least one pair of needles, and at least one suture pair. The suture snag is moveable between a deployed position in which two distal arm portions thereof radially extend away from the elongated body and a retracted position in which the two distal arm portions are disposed within the elongated body. The suture pair is slidingly disposed through the needle pair. The suturing device deploys the suture snag within a vessel adjacent to an arteriotomy, extends the needle pair through a vessel wall around the arteriotomy and through the deployed suture snag, extends the suture pair beyond the distal ends of the needle pair, and then utilizes the suture snag to capture the extended suture pair by retracting the suture snag to pull first or distal ends of the sutures back into the suturing device. An inflatable balloon or an expandable suture capture component may be alternatives to the suture snag for capturing the suture ends.

Abstract translation: 缝合装置包括手柄，细长主体，至少一个缝合线，至少一对针和至少一个缝线对。 缝合线可以在展开位置之间移动，其中两个远端臂部分之间径向延伸离开细长主体，并且其中两个远端臂部分设置在细长主体内的缩回位置。 缝合线对通过针对滑动地布置。 缝合装置在与动脉切开术相邻的血管内展开缝合线，将针对延伸穿过动脉切开术周围的血管壁，并通过展开的缝合线将缝线对延伸超过针对的远端，然后利用 通过缩回缝合线将缝合线的第一或远端拉回到缝合装置中以捕获延伸的缝合线。 可膨胀气囊或可扩张缝合线捕获部件可以是用于捕获缝合线端部的缝合线钩的替代物。

公开(公告)号：WO2014133798A1

公开(公告)日：2014-09-04

申请号：PCT/US2014/016565

申请日：2014-02-14

Applicant: MEDTRONIC VASCULAR INC.

Inventor： ARGENTINE, Jeffery ,  GORMLEY, Stephen ,  PERKINS, Keith ,  WAINERDI, Jennifer ,  JOSAITIS, James ,  O'TOOLE, Thomas ,  CURRAN, Padraic ,  DOOHER, Karl

IPC: A61F2/958

CPC classification number: A61F2/958 ,  A61F2/07 ,  A61F2002/828

Abstract: A stent-graft delivery system includes a balloon (420), a sleeve (430) disposed over the balloon, and a stent graft (100) mounted over the sleeve. The sleeve includes a weakened area (436) between a first end and a second end of the sleeve such that when the balloon is expanded, the balloon expands from a center portion of the balloon towards the ends of the balloon. The weakened area of the sleeve may be a slit, a thinner wall section, grooves, notches, or other weakening features. The sleeve may be adhesively attached to an outer shaft of the catheter or to an outer surface of the balloon.

Abstract translation: 支架移植物递送系统包括球囊（420），设置在球囊上方的套筒（430）和安装在套管上的支架移植物（100）。 套筒包括在套筒的第一端和第二端之间的弱化区域（436），使得当球囊膨胀时，球囊从球囊的中心部分朝向球囊的端部膨胀。 套筒的弱化区域可以是狭缝，较薄的壁部分，凹槽，凹口或其它弱化特征。 套筒可以粘合地附接到导管的外轴或气囊的外表面。

公开(公告)号：WO2013162686A2

公开(公告)日：2013-10-31

申请号：PCT/US2013/026735

申请日：2013-02-19

Applicant: MEDTRONIC VASCULAR INC.

Inventor： MAGGARD, Jason ,  ARGENTINE, Jeffery ,  HAGGARD, Mathew ,  PEARSON, Meghan ,  SIMMONS, Emilie

IPC: A61F2/07

CPC classification number: A61F2/954 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2250/006 ,  A61M25/00

公开(公告)号：WO2012145245A1

公开(公告)日：2012-10-26

申请号：PCT/US2012/033541

申请日：2012-04-13

Applicant: MEDTRONIC VASCULAR INC. ,  PERKINS, Keith ,  ROBAINA, Samuel ,  ARGENTINE, Jeffery ,  BRUSZEWSKI, Walter ,  KIEHL, Andrew

Inventor： PERKINS, Keith ,  ROBAINA, Samuel ,  ARGENTINE, Jeffery ,  BRUSZEWSKI, Walter ,  KIEHL, Andrew

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2/962 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2230/0067

Abstract: A prosthesis comprising a proximal landing zone comprising metal comprising an array of holes therein, wherein a metal to vessel ratio of the proximal landing zone when in the final configuration is sufficiently high to encourage tissue ingrowth around the proximal landing zone yet is sufficiently low to ensure perfusion of a branch vessel through the proximal landing zone; and an exclusion zone attached to the proximal landing zone, the exclusion zone comprising graft material. The metal to vessel ratio is the percentage of the proximal landing zone covered by the metal when the proximal landing zone is in the final configuration. By forming the exclusion zone of graft material, excellent exclusion of the aneurysm is achieved.

Abstract translation: 一种假体，其包括近端着陆区，该近端着陆区包括在其中包括孔阵列的金属，其中当处于最终构型时近端着陆区的金属与血管比例足够高以促进近侧着陆区周围的组织向内生长足够低以确保 通过近端着陆区灌注分支血管; 以及附接到近端着陆区的排除区，所述排除区包括移植材料。 金属与容器的比例是当近端着陆区处于最终构型时由金属覆盖的近端着陆区的百分比。 通过形成移植材料的排除区，实现了优异的动脉瘤排除。

公开(公告)号：WO2019199533A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/025501

申请日：2019-04-03

Applicant: MEDTRONIC VASCULAR, INC.

Inventor： SETHNA, Sohrab ,  ARGENTINE, Jeffery

IPC: A61F2/966 ,  A61F2/95

Abstract: Devices, methods, and systems for prosthesis delivery to patient vasculature are provided. A prosthesis delivery device provided herein delivers a prosthesis to the vasculature of a patient and permits an operator to deploy the prosthesis using a single action mechanism to deploy the prosthesis at a standard deployment rate and a dual action mechanism to deploy the prosthesis at an accelerated deployment rate. Deploying the prosthesis at an accelerated deployment rate results in alterations to the deployed prosthesis structure because the prosthesis is deployed with increased axial compression that results in the prosthesis having increased radial force.