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公开(公告)号：WO2006121861A2
公开(公告)日：2006-11-16
申请号：PCT/US2006017412
申请日：2006-05-05
Applicant: MICROBIA INC , ANTONELLI STEPHEN , LUNDIGRAN-SOUCY REGINA , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J , BARDEN TIMOTHY C , JING-JING YANG , ZIMMER DANIEL P
Inventor： ANTONELLI STEPHEN , LUNDIGRAN-SOUCY REGINA , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J , BARDEN TIMOTHY C , JING-JING YANG , ZIMMER DANIEL P
IPC: A61K31/519 , A61K31/522
CPC classification number: C07D205/08 , C07D405/10 , C07F9/568 , C07F9/65586 , C07H7/04 , C07H15/203
Abstract: The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
Abstract translation: 本发明涉及可用于治疗高胆固醇血症和其他疾病的4-联苯-1-苯基氮杂环丁烷-2-酮的化学属。 化合物具有通式（I）。 还公开了用于治疗胆固醇和脂质相关疾病的药物组合物和方法。
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公开(公告)号：WO2006086562A3
公开(公告)日：2007-03-22
申请号：PCT/US2006004601
申请日：2006-02-09
Applicant: MICROBIA INC , ZIMMER DANIEL P , TALLEY JOHN J , LUNDRIGAN-SOUCY REGINA , ROBERTS SHANNON , MARTINEZ EDUARDO
Inventor： ZIMMER DANIEL P , TALLEY JOHN J , LUNDRIGAN-SOUCY REGINA , ROBERTS SHANNON , MARTINEZ EDUARDO
IPC: C07D205/08 , A61K31/395 , A61P3/06 , A61P3/10 , A61P9/12 , A61P25/28 , C07H5/04 , C07H5/08 , C07K2/00
CPC classification number: C07D405/12 , C07H7/04
Abstract: Various azetidinone derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
Abstract translation: 还描述了各种氮杂环丁酮衍生物，以及含有这些化合物的药物组合物以及使用这些化合物治疗疾病的方法。 还描述了其它实施例。
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公开(公告)号：WO2006122117A3
公开(公告)日：2007-01-18
申请号：PCT/US2006017914
申请日：2006-05-09
Applicant: MICROBIA INC , ZIMMER DANIEL P , TALLEY JOHN J
Inventor： ZIMMER DANIEL P , TALLEY JOHN J
IPC: A61K31/70
CPC classification number: C07F9/3834 , C07F9/4021 , C07F9/568
Abstract: The invention relates to chemical genera of organometal benzenephosphonates useful in cross-coupling organic synthesis, having general formula (I): where R is selected from boron, zinc, tin and silicon residues.
Abstract translation: 本发明涉及可用于交叉偶联有机合成的有机金属苯膦酸酯的化学属性，具有通式（I）：其中R选自硼，锌，锡和硅残基。
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4.发明申请1,4-DIPHENYL-3-HYDROXYALKYL-2-AZETIDINONE DERIVATIVES FOR TREATING HYPERCHOLESTROLEMIA 审中-公开用于治疗高胆固醇的1,4-二苯基-3-羟基喹啉-2-氮杂环丁酮衍生物
公开(公告)号：WO2006122186A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018076
申请日：2006-05-10
Applicant: MICROBIA INC , MARTINEZ EDUARDO , TALLEY JOHN J , ZIMMER DANIEL P
Inventor： MARTINEZ EDUARDO , TALLEY JOHN J , ZIMMER DANIEL P
IPC: A61K31/397
CPC classification number: C07D205/08 , C07D405/10
Abstract: The invention relates to a chemical genus of 1,4-diphenyl-3-hydroxyalkyl-2-azetidinones useful for the treatment of hypercholesterolemia and related disorders, having general formula (I).
Abstract translation: 本发明涉及可用于治疗高胆固醇血症和相关疾病的1,4-二苯基-3-羟基烷基-2-氮杂环丁酮的化学属，具有通式（I）。
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公开(公告)号：WO2008039829A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079506
申请日：2007-09-26
Applicant: MICROBIA INC , TALLEY JOHN J , ZIMMER DANIEL P
Inventor： TALLEY JOHN J , ZIMMER DANIEL P
IPC: A61K31/426
CPC classification number: C07D263/20 , C07D205/06 , C07D207/22 , C07D207/26 , C07D233/32 , C07D263/16 , C07D277/14 , C07D285/00 , C07D405/10 , C07D413/12 , C07F9/5683 , C07F9/5722 , C07F9/65062 , C07F9/653 , C07F9/6536 , C07F9/6539 , C07H7/04
Abstract: Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.
Abstract translation: 还描述了各种氮杂环丁酮，吡咯烷，咪唑烷和恶唑烷衍生物，以及含有这些化合物的药物组合物和使用这些化合物治疗疾病的方法。 还描述了其它实施例。
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Patent Agency Ranking
公开(公告)号：WO2006122216A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018153
申请日：2006-05-11
Applicant: MICROBIA INC , BARDEN TIMOTHY C , LEE PETER , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J
Inventor： BARDEN TIMOTHY C , LEE PETER , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J
IPC: A61K31/397
CPC classification number: C07D263/14 , C07D205/08 , C07F7/1892
Abstract: The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives Formula (1)
Abstract translation: 本发明涉及制备式（1）的酚类4-联苯基氮杂环丁-2-酮衍生物的方法，
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公开(公告)号：WO2006122020A3
公开(公告)日：2007-05-18
申请号：PCT/US2006017706
申请日：2006-05-08
Applicant: MICROBIA INC , LEE PETER , ANTONELLI STEPHEN , LUNDIGRAN-SOUCY REGINA , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J
Inventor： LEE PETER , ANTONELLI STEPHEN , LUNDIGRAN-SOUCY REGINA , MARTINEZ EDUARDO J , SCHAIRER WAYNE C , TALLEY JOHN J
IPC: C07D205/08 , C07C251/24 , C07D263/26 , C07D309/10 , C07D405/10 , C07F5/04
CPC classification number: C07C251/24 , C07C229/34 , C07D205/08 , C07D263/26 , C07D405/10 , C07F5/025 , C07F7/1856 , C07F7/1892
Abstract: The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula (I).
Abstract translation: 本发明涉及制备式（I）的4-联苯基氮杂环丁-2-酮衍生物的方法。
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8.发明申请PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS 审中-公开生产4-（二苯基）亚甲基-2-酮磷酸的方法
公开(公告)号：WO2006127893A2
公开(公告)日：2006-11-30
申请号：PCT/US2006020226
申请日：2006-05-25
Applicant: MICROBIA INC , ANTONELLI STEPHEN , BARDEN TIMOTHY C , LEE PETER , MARTINEZ EDUARDO , SCHAIRER WAYNE C , TALLEY JOHN J
Inventor： ANTONELLI STEPHEN , BARDEN TIMOTHY C , LEE PETER , MARTINEZ EDUARDO , SCHAIRER WAYNE C , TALLEY JOHN J
IPC: A61P3/06 , A61K31/397 , A61K31/662 , C07C251/16 , C07D205/08 , C07D263/26 , C07F5/02 , C07F9/568
CPC classification number: C07C251/24 , C07D205/08 , C07D263/26 , C07D309/30 , C07D309/38 , C07F7/1892 , C07F9/568 , C07F9/5683
Abstract: The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula.
Abstract translation: 本发明涉及制备下式的4-（联苯基）吖丁啶-2-酮膦酸衍生物的方法。
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公开(公告)号：WO2004087686A3
公开(公告)日：2004-12-16
申请号：PCT/IB2004001113
申请日：2004-03-26
Applicant: PHARMACIA CORP , CARTER JEFFERY STEVEN , ASTON KARL WILLIAM , BROWN DAVID LOUIS , DEPROW ANGELA , FLETCHER THERESA , HALLINAN E ANN , HAMPER BRUCE CAMERON , HUFF RENEE , KIEFER JAMES RICHARD JR , KOSZYK FRANCIS , KRAMER STEVEN , LIAO SUBO , LIMBURG DAVID CHRISTOPHER , LUDWIG CINDY , MCCALL JOHN MICHAEL , SPRINGER JOHN ROBERT , TALLEY JOHN J , WANG LIJUAN JANE , XING LI , YU YI
Inventor： CARTER JEFFERY STEVEN , ASTON KARL WILLIAM , BROWN DAVID LOUIS , DEPROW ANGELA , FLETCHER THERESA , HALLINAN E ANN , HAMPER BRUCE CAMERON , HUFF RENEE , KIEFER JAMES RICHARD JR , KOSZYK FRANCIS , KRAMER STEVEN , LIAO SUBO , LIMBURG DAVID CHRISTOPHER , LUDWIG CINDY , MCCALL JOHN MICHAEL , SPRINGER JOHN ROBERT , TALLEY JOHN J , WANG LIJUAN JANE , XING LI , YU YI
IPC: A61K31/352 , A61K31/382 , A61K31/395 , A61K31/47 , A61K31/4709 , A61P29/00 , C07D20060101 , C07D215/38 , C07D215/54 , C07D311/58 , C07D311/64 , C07D311/92 , C07D335/06 , C07D401/02 , C07D405/02 , C07D407/02 , C07D409/02 , C07D493/04
CPC classification number: C07D311/58 , C07D311/64 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04 , C07D417/06 , C07D493/04
Abstract: The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R , R , R , and R are as described in specification.
Abstract translation: 本发明涉及可用于治疗与环氧合酶-2介导的疾病有关的病症的方法和化合物。 特别感兴趣的化合物是苯并吡喃及其由式（1）定义的类似物。 其中Z，X，R 1，R 2，R 3和R 4如说明书中所述。
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公开(公告)号：WO2008061238A3
公开(公告)日：2008-09-25
申请号：PCT/US2007085003
申请日：2007-11-16
Applicant: IRONWOOD PHARMACEUTICALS INC , TALLEY JOHN J , BARDEN TIMOTHY C
Inventor： TALLEY JOHN J , BARDEN TIMOTHY C
IPC: C07D205/08 , A61K31/397 , A61P9/00
CPC classification number: C07D205/08 , C07C249/02 , C07C251/24
Abstract: The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula (I).
Abstract translation: 本发明涉及制备式（I）的4-联苯基氮杂环丁-2-酮衍生物的方法。
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