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公开(公告)号：WO2019161151A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018136
申请日：2019-02-15
摘要： The present disclosure provides modified, transgenic, or genome edited/mutated corn plants that are semi-dwarf and have one or more improved ear traits relative to a control plant, such as increase in ear diameter, single kernel weight, ear fresh weight, ear area, ear volume, ear length, number of kernels per ear, and yield. The modified, transgenic, or genome edited/mutated corn plants comprise a transgene encoding one or more MADS-box polypeptides and have a reduced expression of one or more GA20 or GA3 oxidase genes. Also provided are methods for producing the modified, transgenic, or genome edited/mutated corn plants.
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公开(公告)号：WO2019161146A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018130
申请日：2019-02-15
发明人： ALVES-JUNIOR, Leonardo , BRUCE, Wesley B. , DIETRICH, Charles R. , IVLEVA, Natalia , KIANI, Kian , RAPP, Ryan , SLEWINSKI, Thomas L.
摘要： The present disclosure provides modified, transgenic, or genome edited/mutated corn plants that are semi-dwarf and have one or more improved ear traits relative to a control plant, such as increase in ear area, increased single kernel weight, increased ear fresh weight, increased number of florets, and mitigated flowering delay. The modified, transgenic, or genome edited/mutated corn plants comprise a transgene encoding one or more CONSTANS (CO) or CONSTANS-like (COL) polypeptide and have a reduced expression of one or more GA20 or GA3 oxidase genes. Also provided are methods for producing the modified, transgenic, or genome edited/mutated corn plants.
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3.发明申请
公开(公告)号：WO2020243363A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034996
申请日：2020-05-28
摘要： The present disclosure provides compositions and methods for altering gibberellin (GA) content in corn or other cereal plants. Methods and compositions are also provided for altering the expression of genes related to gibberellin biosynthesis through editing of a specific GA20 oxidase gene or locus to produce a genomic deletion or disruption that brings an antisense sequence of the GA20 oxidase gene under the control of a neighboring SAMT gene promoter. Modified plant cells and plants having a dominant allele reducing the expression or activity of one or more GA oxidase genes are further provided comprising reduced gibberellin levels and improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types.
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4.发明申请
公开(公告)号：WO2019161147A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018131
申请日：2019-02-15
摘要： The present disclosure provides compositions and methods for the editing or mutating of specific subtypes of GA20 oxidase genes and specific zygosity combinations of those edits or mutations. Modified plants, and plant parts and cells thereof, having mutations reducing the expression or activity of GA20 oxidase genes are further provided with improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types. Methods are further provided for making modified plants, and plant parts and cells thereof, having one or more mutations in specific subtypes of GA20 oxidase genes.
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5.发明申请METHODS AND COMPOSITIONS FOR SHORT STATURE PLANTS THROUGH MANIPULATION OF GIBBERELLIN METABOLISM TO INCREASE HARVESTABLE YIELD 审中-公开通过调控GABBERELLIN代谢来提高可收获产量的短期植物的方法和组合物
公开(公告)号：WO2018035354A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047405
申请日：2017-08-17
发明人： ALLEN, Edwards M. , BODDU, Jayanand , DIETRICH, Charles R. , GOLDSHMIDT, Alexander , HOWELL, Miya , KOSOLA, Kevin R. , NEELAM, Anil , SLEWINSKI, Thomas L. , VENKATESH, Tyamagondlu V. , WANG, Huai
摘要： The present disclosure provides compositions and methods for altering gibberellin (GA) content in corn or other cereal plants. Methods and compositions are also provided for altering the expression of genes related to gibberellin biosynthesis through suppression, mutagenesis and/or editing of specific subtypes of GA20 or GA3 oxidase genes. Modified plant cells and plants having a suppression element or mutation reducing the expression or activity of a GA oxidase gene are further provided comprising reduced gibberellin levels and improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types.
摘要翻译： 本公开提供用于改变玉米或其他谷类植物中的赤霉素（GA）含量的组合物和方法。 还提供了通过抑制，诱变和/或编辑GA20或GA3氧化酶基因的特定亚型来改变与赤霉素生物合成有关的基因表达的方法和组合物。 进一步提供了具有降低GA氧化酶基因的表达或活性的抑制元件或突变的修饰的植物细胞和植物，其包含降低的赤霉素水平和改善的特征，例如降低的植物高度和增加的抗倒伏性，但没有脱落类型。 p>
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6.发明申请
公开(公告)号：WO2022109286A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/060116
申请日：2021-11-19
IPC分类号： C07K14/415 , C12N15/63 , C12N15/82
摘要： The present disclosure provides compositions and methods for altering auxin accumulation in corn or other cereal plants. Methods and compositions are also provided for altering the expression of genes related to auxin efflux through editing of a Brachytic2 (br2) gene to introduce an antisense sequence or segment or a deletion or premature stop codon into the gene. Modified plant cells and plants having a dominant or semi-dominant allele reducing the expression or activity of a br2 gene product are further provided comprising improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types in the plant.
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公开(公告)号：WO2019161148A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018132
申请日：2019-02-15
发明人： ALVES-JUNIOR, Leonardo , BRUCE, Wesley B. , CHITTOOR, Jaishree , DIETRICH, Charles R. , IVLEVA, Natalia , LI, Hong , SLEWINSKI, Thomas L. , WU, Xiaoyun
摘要： The present disclosure provides modified, transgenic, or genome edited/mutated corn plants that are semi-dwarf and have one or more improved ear traits relative to a control plant, such as increase in ear diameter, ear fresh weight, and single kernel weight, and increased yield. The modified, transgenic, or genome edited/mutated corn plants comprise a transgene encoding one or more molybdenum cofactor (Moco) biosynthesis polypeptides and have a reduced expression of one or more GA20 or GA3 oxidase genes. Also provided are methods for producing the modified, transgenic, or genome edited/mutated corn plants.
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8.发明申请
公开(公告)号：WO2019161144A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/018128
申请日：2019-02-15
摘要： The present disclosure provides compositions and methods for altering gibberellin (GA) content in corn or other cereal plants. Methods and compositions are also provided for altering the expression of genes related to gibberellin biosynthesis through suppression, mutagenesis and/or editing of specific subtypes of GA20 or GA3 oxidase genes. Modified plant cells and plants having a suppression element or mutation reducing the expression or activity of a GA oxidase gene are further provided comprising reduced gibberellin levels and improved characteristics, such as reduced plant height and increased lodging resistance, but without off-types.
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公开(公告)号：WO2021030539A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/046082
申请日：2020-08-13
发明人： DIETRICH, Charles R. , IVLEVA, Natalia , SLEWINSKI, Thomas L. , BRUCE, Wesley B. , ALVES-JUNIOR, Leonardo
摘要： The present disclosure provides modified, transgenic, or genome edited/mutated corn plants that are semi-dwarf and have one or more improved ear traits relative to a control plant, such as increase in ear area, ear diameter, ear length, green leaf number below ear, yield, single kernel weight, and/or ear fresh weight, and decrease in ear tip void. The modified, transgenic, or genome edited/mutated corn plants comprise a transgene encoding one or more proliferating cell nuclear antigen (PCNA) polypeptide and have a reduced expression of one or more GA20 or GA3 oxidase genes. Also provided are methods for producing the modified, transgenic, or genome edited/mutated corn plants.
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公开(公告)号：WO2020243368A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035001
申请日：2020-05-28
发明人： CARGILL, Edward James , EUDY, Douglas Michael , KOURANOV, Andrei Y. , LAWRENCE, Richard Joseph , SLEWINSKI, Thomas L. , SHULTZ, Randy , TO, PokChun Jennnifer , YANG, Samuel Sukhwan , ZHANG, Yuanji
IPC分类号： C12N15/113 , A61K48/00 , C12N5/10 , C07K14/415 , C12N15/102 , C12N15/1137 , C12N15/8213 , C12N15/8216 , C12N15/8218 , C12N15/8223 , C12N15/8226 , C12N15/8261 , C12N15/8262 , C12N15/8286 , C12N15/8297 , C12N15/902 , C12N2310/11 , C12N2310/127 , C12N2310/141 , C12N2310/20 , C12N2320/34 , C12N9/0071 , C12N9/22 , A40
摘要： The present disclosure provides methods and compositions for generating dominant alleles using targeted editing techniques. Also provided are modified chromosomes, cells, tissues, and plants comprising modified dominant allele.
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