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    METHOD AND APPARATUS FOR LEAK DETECTION IN A FLUID LINE
    2.
    发明申请
    METHOD AND APPARATUS FOR LEAK DETECTION IN A FLUID LINE 审中-公开
    流体液体泄漏检测方法及装置

    公开(公告)号：WO03006944A3

    公开(公告)日：2003-10-09

    申请号：PCT/US0221372

    申请日：2002-07-08

    Applicant: NXSTAGE MEDICAL INC ,  BRUGGER JAMES ,  BURBANK JEFFREY

    Inventor： BRUGGER JAMES ,  BURBANK JEFFREY

    IPC: A61M1/36 ,  A61M37/00 ,  B01D11/00 ,  B01D35/00 ,  B01D35/14 ,  B01D35/147 ,  B01D61/00 ,  C02F1/00 ,  C02F1/44

    CPC classification number: A61M1/3626 ,  A61M1/3656 ,  A61M2205/13

    Abstract: One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Such systems draw blood at such a high rate that a loss of integrity in the blood circuit can be catastrophic. The most reliable leak detection method known is the detection of infiltrated air in the blood line, but this only works in blood lines under negative pressure. According to the invention, a leak detector for return lines is provided by periodically generating a negative pressure, which may be brief or at a 50 % duty cycle, in the blood return line to draw air into it and thereby reveal the leaks using an air sensor (345). Although the return line is ordinarily under positive pressure, during the negative pressure cycle, the blood return line draws air through any leaks or disconnects. If air is detected, the system is shut down and an alarm (330) is generated.

    Abstract translation: 体外血液治疗如透析自动化中最重要的安全问题之一是出现血液渗漏的风险。 这样的系统以如此高的速度吸取血液，使得血液回路中完整性的丧失可能是灾难性的。 已知的最可靠的泄漏检测方法是检测血液中的渗透空气，但这只能在负压下的血液系统中起作用。 根据本发明，通过在血液回流管线周期性地产生负压（可以是短暂的或占空比为50％）来提供返回管线的泄漏检测器，以将空气吸入其中，从而使用空气泄露泄漏 传感器（345）。 虽然返回线通常处于正压力下，但是在负压循环期间，血液回流管路通过任何泄漏或断开线吸入空气。 如果检测到空气，则关闭系统并产生报警（330）。

    IMPROVED METHODS AND APPARATUS FOR LEAK DETECTION IN BLOOD PROCESSING SYSTEMS
    6.
    发明申请
    IMPROVED METHODS AND APPARATUS FOR LEAK DETECTION IN BLOOD PROCESSING SYSTEMS 审中-公开
    改进的方法和装置用于血液加工系统中的泄漏检测

    公开(公告)号：WO2005046439A3

    公开(公告)日：2006-01-12

    申请号：PCT/US2004036933

    申请日：2004-11-05

    Applicant: NXSTAGE MEDICAL INC

    Inventor： BRUGGER JAMES ,  MCDOWELL CHRISTOPHER S

    IPC: A61B20060101 ,  A61M1/36 ,  A61M39/22 ,  A61M37/00 ,  A61M1/00

    CPC classification number: A61M1/367 ,  A61M1/3626 ,  A61M1/3653 ,  A61M1/3656 ,  A61M39/223 ,  A61M2205/15 ,  Y10T137/86831

    Abstract: A blood processing system includes a flow reversing device with at least an air sensor in the venous line located near the patient. During treatment, blood flow is reversed to cause air to infiltrate the blood lines if any disconnections or breaks in the blood line are present. One means for placing the sensor close to the patient is to provide the flow switching device and sensors in a small lightweight module that can be located close the treatment machine. Another is to provide a module with just the sensors near the access.

    Abstract translation: 血液处理系统包括在位于患者附近的静脉线中至少具有空气传感器的流动反转装置。 在治疗过程中，如果存在血液管线中的任何断开或断裂，血流量会相反，导致空气渗入血管。 用于将传感器放置在患者身上的一种方法是将流量切换装置和传感器提供在一个可以靠近治疗机器的小型轻型模块中。 另一个是在访问附近提供一个只有传感器的模块。

    BLOOD CIRCUIT WITH LEAK-SAFE FEATURES
    7.
    发明申请
    BLOOD CIRCUIT WITH LEAK-SAFE FEATURES 审中-公开
    具有泄漏安全特性的血液回路

    公开(公告)号：WO2004084972A3

    公开(公告)日：2005-05-06

    申请号：PCT/US2004008452

    申请日：2004-03-19

    Applicant: NXSTAGE MEDICAL INC

    Inventor： BURBANK JEFFREY ,  BRUGGER JAMES

    IPC: A61M1/36 ,  A61M37/00

    CPC classification number: A61M1/3653 ,  A61M1/3626 ,  A61M1/3656 ,  A61M1/3659

    Abstract: A leak safe access needle and blood circuit are combined in a fluid circuit with the access needle configured as a double lumen access needle whose venous line is permanently attached to the fluid circuit. The arterial line has an air detection device. In this configuration, the only way the venous line can be disconnected is for the access needle to be withdrawn from the patient, which will necessarily result in disconnection of the arterial line, which in turn will be detected by air infiltration into the arterial line. This combination ensures that venous disconnects are revealed by the air detection. Other embodiments allow non-permanent connection of the venous line.

    Abstract translation: 泄漏安全检查针和血液回路组合在流体回路中，进入针被配置为双腔管接头针，其静脉管线永久地附接到流体回路。 动脉线具有空气检测装置。 在这种构造中，静脉管线可以断开的唯一方式是使得进入针从病人身体中取出，这将必然导致动脉管线的断开，这又会被空气渗透到动脉管线中而被检测到。 这种组合可确保通过空气检测显示静脉断开。 其他实施例允许静脉管线的非永久性连接。

    BATCH FILTRATION SYSTEM FOR PREPARATION OF STERILE REPLACEMENT FLUID FOR RENAL THERAPY
    9.
    发明申请
    BATCH FILTRATION SYSTEM FOR PREPARATION OF STERILE REPLACEMENT FLUID FOR RENAL THERAPY 审中-公开
    用于制备用于肾功能治疗的无效替代液的批量过滤系统

    公开(公告)号：WO2004062710A3

    公开(公告)日：2004-10-21

    申请号：PCT/US2004000476

    申请日：2004-01-07

    Applicant: BRUGGER JAMES ,  BURBANK JEFFREY ,  NXSTAGE MEDICAL INC ,  GREEN BRIAN

    Inventor： BRUGGER JAMES ,  BURBANK JEFFREY ,  GREEN BRIAN

    IPC: A61M20060101 ,  A61M1/16 ,  B01D61/00 ,  B01D61/24 ,  B01D61/28 ,  B01D61/30 ,  B01D61/32

    CPC classification number: A61M1/1656 ,  A61M1/14 ,  A61M1/166 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1674 ,  A61M1/28 ,  A61M1/288 ,  A61M1/3462 ,  A61M2205/12 ,  C02F1/44

    Abstract: A method and device for blood treatment involving infusion of replacement fluid are provided. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter (11) from a fluid source to a replacement fluid container (1). The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering need not match the rate of consumption during treatment. As a result, the sterilization filter (11) can have a small capacity. In another embodiment, a filter (11) is placed immediately prior to the point at which replacement fluid is injected into the patient's bloodstream. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.

    Abstract translation: 提供了一种涉及输液置换液的血液处理方法和装置。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器（11）从流体源传递到替换流体容器（1）。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器（11）可以具有小容量。 在另一个实施方案中，将过滤器（11）立即放置在将替换流体注入患者血流中的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。

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