公开(公告)号：WO2017192572A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/030617

申请日：2017-05-02

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  SENCHYNA, Diane Michelle ,  HAMILTON, Daniel N.

IPC: A61N1/36

Abstract: Described here are devices, systems, and methods for treating meibomian gland disease and/or blepharitis by providing intranasal stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may unblock obstructed meibomian glands and increase the lipid content of tears, both acutely during stimulation and subsequent to intranasal stimulation. The methods may include an initial round of stimulation to unblock obstructed meibomian glands, and subsequent shorter rounds of stimulation to cause meibum secretion and maintain the open glands.

Abstract translation: 这里描述的是通过提供鼻内刺激来治疗睑板腺疾病和/或睑缘炎的装置，系统和方法。 通常，这些装置可以将电刺激递送至鼻粘膜。 鼻内刺激可以在刺激和鼻内刺激之后急剧地打开阻塞的睑板腺和增加泪液的脂质含量。 这些方法可能包括最初的一轮刺激来打开阻塞的睑板腺，然后进行较短时间的刺激以引起睑脂分泌并维持开放的腺体。

公开(公告)号：WO2016065215A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/057023

申请日：2015-10-22

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  LOUDIN, James, Donald ,  WARDLE, John ,  HOLDBROOK, Mark, Jeffrey

IPC: A61N1/36

CPC classification number: A61N1/36046 ,  A61N1/0526 ,  A61N1/0546 ,  A61N1/3606 ,  A61N1/36146 ,  A61N1/37205 ,  A61N1/37247 ,  A61N1/3756 ,  A61N1/3758

Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.

Abstract translation: 本文描述了用于治疗干眼症，疲劳的眼睛或其它形式的眼部不适的装置和方法，例如由隐形眼镜。 方法通常包括将空间和/或时间图案化的刺激应用于位于眼睛或鼻部区域中的一个或多个解剖结构。 电刺激可以引起激活泪腺的反射，或者可以直接激活支配泪腺的泪腺或神经以产生泪液。 所述装置可以是可植入的或手持式的，并且可以被配置为递送所描述的空间和/或时间图案化的刺激图案。

公开(公告)号：WO2018102778A1

公开(公告)日：2018-06-07

申请号：PCT/US2017/064353

申请日：2017-12-01

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  LIU, Chao ,  ACKERMANN, Douglas, Michael ,  SENCHYNA, Diane, Michelle ,  LOUDIN, James, Donald

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/14 ,  A61B5/00 ,  A61F9/00 ,  A61F9/007 ,  A61N1/36

Abstract: A stimulation system for treating a condition (e.g., dry eye, Meibomian gland disease) of a subject includes a stimulator configured to deliver a stimulus to external facial tissue of the subject, at least one sensor configured to detect a characteristic of the subject, and a control system in communication with the sensor and configured to adjust the stimulus at least partially based on the detected subject characteristic. In some variations, the control system may be configured to adjust the stimulus at least partially based on a detected environmental condition. The stimulator may be configured to activate a nerve of the subject, thereby increasing tear production. The stimulation system may, for example, include a device configured to be worn by a subject such as eyeglasses or a mask, or held by a subject such as handheld stimulator device.

公开(公告)号：WO2018102535A1

公开(公告)日：2018-06-07

申请号：PCT/US2017/063916

申请日：2017-11-30

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  LIU, Chao ,  MURALIDHARAN, Abirami ,  LOUDIN, James Donald ,  ACKERMANN, Douglas Michael ,  ROGERS, Michael G.

IPC: A61B3/10 ,  G16H50/20

Abstract: Generally, a machine may include a processor and a memory connected to the processor, where the memory stores instructions executed by the processor to determine first and second properties related to dry eye symptoms of a patient. The properties may be used to form a dry eye forecast. A treatment recommendation may be selected based at least in part upon the dry eye forecast. The treatment recommendation may be supplied to a device.

公开(公告)号：WO2016065213A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/057021

申请日：2015-10-22

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  LOUDIN, James, Donald ,  KUZMA, Janusz ,  YUN, Paul, Taehyun ,  ACKERMANN, Douglas, Michael

IPC: A61N1/36

CPC classification number: A61N1/36046 ,  A61N1/3606 ,  A61N1/37205 ,  A61N1/3756 ,  A61N2001/37294

Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.

Abstract translation: 这里描述的是用于将鼻刺激剂植入鼻组织并电刺激鼻组织的系统，装置和方法。 在一些变型中，鼻微型刺激器植入系统可以包括植入工具和可植入微型刺激器。 植入工具可以包括轴和用于可释放地附接微刺激器的特征。 微型激励器可以包括无源刺激电路和一个或多个电极。 在其他变型中，鼻部植入系统可另外包括一个或多个附加装置，例如控制器，电探针和/或解剖工具。

公开(公告)号：WO2016065211A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/057019

申请日：2015-10-22

Applicant: OCULEVE, INC.

Inventor： LOUDIN, James, Donald ,  FRANKE, Manfred ,  HAMILTON, Daniel, N. ,  DORAISWAMY, Anand ,  ACKERMANN, Douglas, Michael

IPC: A61N1/36

CPC classification number: A61N1/3787 ,  A61N1/36046 ,  A61N1/36121 ,  B29D11/00038 ,  B29D11/00826

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

Abstract translation: 这里描述的是通过刺激角膜，结膜和/或结膜下增加泪液产生的装置，系统和方法。 在一些变型中，装置可以是隐形眼镜的形式。 隐形眼镜可以包括透镜体和刺激器芯片，其中刺激器芯片嵌入在透镜体中。 外部电源将能量无线地传输到刺激器芯片，其中刺激器芯片可以将能量转换成电波形以刺激角膜，结膜和/或结膜下。 刺激可以激活泪液反射以增加泪液产生。 用于增加泪液生产的装置和系统可以用于治疗干眼症，减少疲劳眼睛的症状，增加隐形眼镜佩戴者的舒适度以及延长隐形眼镜用户可佩戴接触的年数的方法。 还描述了制造隐形眼镜的方法。

公开(公告)号：WO2016015025A1

公开(公告)日：2016-01-28

申请号：PCT/US2015/042130

申请日：2015-07-24

Applicant: OCULEVE, INC.

Inventor： FRANKE, Manfred ,  LOUDIN, James, Donald

IPC: A61N1/05

CPC classification number: A61N1/36046 ,  A61N1/0526 ,  A61N1/0546 ,  A61N1/3606 ,  A61N1/36146 ,  A61N1/3756

Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.

Abstract translation: 本文描述的是电刺激模式及其用于治疗干眼病，疲劳的眼睛或其它形式的眼部不适的方法。 所述方法通常包括将图案刺激应用于位于眼部区域或鼻部区域中的解剖结构以增加泪液产生。