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公开(公告)号：WO2012139063A2
公开(公告)日：2012-10-11
申请号：PCT/US2012/032629
申请日：2012-04-06
Applicant: OCULEVE, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ACKERMANN, Douglas, Michael , LOUDIN, James, Donald , KUZMA, Janusz , PALANKER, Daniel , WETENKAMP, Scott, Franklin
Inventor： ACKERMANN, Douglas, Michael , LOUDIN, James, Donald , KUZMA, Janusz , PALANKER, Daniel , WETENKAMP, Scott, Franklin
CPC classification number: A61N1/37205 , A61N1/0526 , A61N1/36046 , A61N1/37229
Abstract: Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a micro stimulator. The components of the controller and micro stimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and micro stimulator may communicate wirelessly or via a wired connection. The micro stimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the micro stimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.
Abstract translation: 这里描述的是用于刺激患者中的一个或多个解剖目标以用于诸如干眼的治疗状况的刺激系统和方法。 刺激系统可以包括控制器和微刺激器。 控制器和微刺激器的组件可以在单个单元中或在单独的设备中实现。 当单独实施时，控制器和微刺激器可以无线通信或通过有线连接进行通信。 微刺激器可以根据从控制器接收的信号生成脉冲并且将该信号经由一个或多个电极施加到解剖目标。 在一些变型中，微刺激器可以包括被动生成电路，被配置为基于从控制器接收的信号生成脉冲。
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公开(公告)号：WO2014165124A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/024496
申请日：2014-03-12
Applicant: OCULEVE, INC.
Inventor： KUZMA, Janusz , ACKERMANN, Douglas, Michael , STIVERS, Christopher, William , LOUDIN, James, Donald
CPC classification number: A61F9/007 , A61F2/14 , A61F2/141 , A61F2/148 , A61F2/1662 , A61F9/0017 , A61M31/007 , A61M2210/0612
Abstract: Described here are systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may comprise a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further comprise a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.
Abstract translation: 这里描述的是用于将植入物递送到轨道的系统，装置和方法。 在一些情况下，系统可以包括具有舌部件和手柄的输送装置。 输送装置还可以包括被配置成从舌部件输送植入物的喷射器。 输送装置还可以包括构造成在组织中产生开口的刺穿构件。 该系统还可以包括用于在组织中形成开口的刺穿构件。 在一些情况下，穿刺构件可以具有可旋转地连接到第二叶片构件的第一叶片构件。
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公开(公告)号：WO2016065215A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057023
申请日：2015-10-22
Applicant: OCULEVE, INC.
Inventor： FRANKE, Manfred , LOUDIN, James, Donald , WARDLE, John , HOLDBROOK, Mark, Jeffrey
IPC: A61N1/36
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
Abstract translation: 本文描述了用于治疗干眼症，疲劳的眼睛或其它形式的眼部不适的装置和方法，例如由隐形眼镜。 方法通常包括将空间和/或时间图案化的刺激应用于位于眼睛或鼻部区域中的一个或多个解剖结构。 电刺激可以引起激活泪腺的反射，或者可以直接激活支配泪腺的泪腺或神经以产生泪液。 所述装置可以是可植入的或手持式的，并且可以被配置为递送所描述的空间和/或时间图案化的刺激图案。
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公开(公告)号：WO2014172693A3
公开(公告)日：2014-10-23
申请号：PCT/US2014/034733
申请日：2014-04-18
Applicant: OCULEVE, INC.
Inventor： ACKERMANN, Douglas, Michael , LOUDIN, James, Donald , WARDLE, John , BALDWIN, Jarren, Armond , HAMILTON, Daniel, N. , KUZMA, Janusz , STIVERS, Christopher, William
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
Abstract translation: 这里描述的是通过向鼻或鼻窦组织提供刺激来治疗一种或多种病症（例如干眼症）或改善眼睛健康的装置，系统和方法。 通常，这些装置可以是手持的或可植入的。 在一些变型中，手持设备可具有刺激器主体和具有一个或多个鼻插入叉的刺激器探针。 当该装置和系统用于治疗干眼症时，可以刺激鼻腔或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼表健康。
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公开(公告)号：WO2014138709A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/022158
申请日：2014-03-07
Applicant: OCULEVE, INC.
Inventor： ACKERMANN, Douglas, Michael , LOUDIN, James, Donald
CPC classification number: A61N1/37217 , A61N1/0526 , A61N1/36046
Abstract: Described here are devices, systems, and methods for treating a condition in an animal. Generally the systems include a stimulator that is implantable in the animal and a controller system configured to transmit one or more signals to the implanted stimulator. The controller system may have a controller configured to generate the one or more signals. The controller system may include one or more collars, bridles, horse hoods, cages, animal beds, and/or food bowls. The systems may be used to treat one or more conditions such as dry eye, and may treat the conditions in an animal such as a horse, dog, or cat.
Abstract translation: 这里描述的是用于治疗动物状况的装置，系统和方法。 通常，系统包括可植入动物的刺激器和被配置为将一个或多个信号传输到植入的刺激器的控制器系统。 控制器系统可以具有被配置为产生一个或多个信号的控制器。 控制器系统可以包括一个或多个衣领，绷腿，马罩，笼子，动物床和/或食物碗。 该系统可用于治疗一种或多种病症如干眼症，并且可以治疗动物如马，狗或猫的病症。
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Patent Agency Ranking
公开(公告)号：WO2018102778A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064353
申请日：2017-12-01
Applicant: OCULEVE, INC.
Inventor： FRANKE, Manfred , LIU, Chao , ACKERMANN, Douglas, Michael , SENCHYNA, Diane, Michelle , LOUDIN, James, Donald
Abstract: A stimulation system for treating a condition (e.g., dry eye, Meibomian gland disease) of a subject includes a stimulator configured to deliver a stimulus to external facial tissue of the subject, at least one sensor configured to detect a characteristic of the subject, and a control system in communication with the sensor and configured to adjust the stimulus at least partially based on the detected subject characteristic. In some variations, the control system may be configured to adjust the stimulus at least partially based on a detected environmental condition. The stimulator may be configured to activate a nerve of the subject, thereby increasing tear production. The stimulation system may, for example, include a device configured to be worn by a subject such as eyeglasses or a mask, or held by a subject such as handheld stimulator device.
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公开(公告)号：WO2016065213A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057021
申请日：2015-10-22
Applicant: OCULEVE, INC.
Inventor： FRANKE, Manfred , LOUDIN, James, Donald , KUZMA, Janusz , YUN, Paul, Taehyun , ACKERMANN, Douglas, Michael
IPC: A61N1/36
CPC classification number: A61N1/36046 , A61N1/3606 , A61N1/37205 , A61N1/3756 , A61N2001/37294
Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
Abstract translation: 这里描述的是用于将鼻刺激剂植入鼻组织并电刺激鼻组织的系统，装置和方法。 在一些变型中，鼻微型刺激器植入系统可以包括植入工具和可植入微型刺激器。 植入工具可以包括轴和用于可释放地附接微刺激器的特征。 微型激励器可以包括无源刺激电路和一个或多个电极。 在其他变型中，鼻部植入系统可另外包括一个或多个附加装置，例如控制器，电探针和/或解剖工具。
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公开(公告)号：WO2016065211A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057019
申请日：2015-10-22
Applicant: OCULEVE, INC.
Inventor： LOUDIN, James, Donald , FRANKE, Manfred , HAMILTON, Daniel, N. , DORAISWAMY, Anand , ACKERMANN, Douglas, Michael
IPC: A61N1/36
CPC classification number: A61N1/3787 , A61N1/36046 , A61N1/36121 , B29D11/00038 , B29D11/00826
Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
Abstract translation: 这里描述的是通过刺激角膜，结膜和/或结膜下增加泪液产生的装置，系统和方法。 在一些变型中，装置可以是隐形眼镜的形式。 隐形眼镜可以包括透镜体和刺激器芯片，其中刺激器芯片嵌入在透镜体中。 外部电源将能量无线地传输到刺激器芯片，其中刺激器芯片可以将能量转换成电波形以刺激角膜，结膜和/或结膜下。 刺激可以激活泪液反射以增加泪液产生。 用于增加泪液生产的装置和系统可以用于治疗干眼症，减少疲劳眼睛的症状，增加隐形眼镜佩戴者的舒适度以及延长隐形眼镜用户可佩戴接触的年数的方法。 还描述了制造隐形眼镜的方法。
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公开(公告)号：WO2016015025A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042130
申请日：2015-07-24
Applicant: OCULEVE, INC.
Inventor： FRANKE, Manfred , LOUDIN, James, Donald
IPC: A61N1/05
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/3756
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
Abstract translation: 本文描述的是电刺激模式及其用于治疗干眼病，疲劳的眼睛或其它形式的眼部不适的方法。 所述方法通常包括将图案刺激应用于位于眼部区域或鼻部区域中的解剖结构以增加泪液产生。
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公开(公告)号：WO2015130707A2
公开(公告)日：2015-09-03
申请号：PCT/US2015/017379
申请日：2015-02-24
Applicant: OCULEVE, INC.
Inventor： LOUDIN, James, Donald , GUPTA, Amitava , WARDLE, John , STIVERS, Christopher, William , DORAISWAMY, Anand , CHRIST, Marie, Dvorak , CHRIST, F., Richard
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
Abstract translation: 本文描述了用于促进鼻或鼻窦组织的电刺激的聚合物制剂。 聚合物制剂可以是通过UV交联工艺制备的水凝胶。 可以包含水凝胶作为鼻刺激器装置的组件，其电刺激泪腺以改善眼泪产生并治疗干眼症。 另外，本文描述了用于制造鼻刺激器的装置和方法，包括水凝胶的成形。
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