公开(公告)号：WO1991009678A1

公开(公告)日：1991-07-11

申请号：PCT/US1990007492

申请日：1990-12-18

Applicant: OMNI QUEST CORPORATION

Inventor： OMNI QUEST CORPORATION ,  CHAGNON, Mark, S.

IPC: B03C01/00

CPC classification number: B82Y5/00 ,  A61K49/183 ,  A61K49/1833 ,  B03C1/01 ,  G01N33/54313 ,  G01N33/5434 ,  G01N33/551 ,  G01N2446/20 ,  G01N2446/80 ,  G01N2446/84 ,  G01N2446/90

Abstract: Magnetically responsive particles and to their use in systems in which the separation of certain molecules from the surrounding medium is necessary or desirable are disclosed. The magnetically responsive particles consist of a metal, metal oxide or metal alloy core, coated with an organo-metallic polymer having attached thereto an organic functionality to which a variety of organic and/or biological molecules can be coupled. The particles can be dispersed in aqueous media without rapid gravitational settling and conveniently reclaimed from the media using a magnetic field. The magnetically responsive particles of the invention may be coupled to biological or organic molecules with affinity for, or the ability to absorb, or which interact with certain other biological or organic molecules. Particles so coupled may be used in a variety of in vitro or in vivo systems involving separations steps or the directed movement of coupled molecules to particular sites, including immunological assays, other biological assays, biochemical or enzymatic reactions, affinity chromatographic purification, cell sorting and diagnostic and therapeutic uses.

Abstract translation: 公开了磁响应颗粒及其在某些分子与周围介质的分离是必需或期望的系统中的用途。 磁响应颗粒由金属，金属氧化物或金属合金芯组成，涂覆有有机金属聚合物，其附着有有机官能团，各种有机和/或生物分子可以偶合到其上。 颗粒可以分散在水介质中，而不需要快速重力沉降，并且可以方便地使用磁场从介质中回收。 本发明的磁响应性颗粒可以与生物或有机分子偶联，具有与某些其它生物或有机分子的亲和力或吸收能力或与之相互作用的生物或有机分子。 如此偶联的颗粒可用于各种体外或体内系统，包括分离步骤或偶联分子到特定位点的定向运动，包括免疫测定，其他生物测定，生物化学或酶反应，亲和层析纯化，细胞分选和 诊断和治疗用途。

公开(公告)号：WO1992000596A1

公开(公告)日：1992-01-09

申请号：PCT/US1990003637

申请日：1990-06-28

Applicant: OMNI QUEST CORPORATION

Inventor： OMNI QUEST CORPORATION ,  CHAGNON, Mark, S. ,  FERRIS, John, R.

IPC: H01F01/117

CPC classification number: H01F41/16 ,  G11B5/70678

Abstract: Magnetic inks useful for the production of magnetic recording products are disclosed. The present magnetic inks contain ferromagnetic barium ferrite particles dispersed in a flexible polymer medium.

Abstract translation: 公开了用于生产磁记录产品的磁性油墨。 本发明的磁性油墨含有分散在柔性聚合物介质中的铁磁性钡铁氧体颗粒。

公开(公告)号：WO1990015423A1

公开(公告)日：1990-12-13

申请号：PCT/US1990003177

申请日：1990-06-05

Applicant: OMNI QUEST CORPORATION

Inventor： OMNI QUEST CORPORATION ,  CHAGNON, Mark, S.

IPC: H01F01/37

CPC classification number: H01F1/442 ,  H01F1/44

Abstract: Electrically-conductive superparamagnetic liquid colloids and methods for making and using them are described. The magnetic liquid colloids contain magnetic particles coated with a conductive, organo-metallic compound, which impart the magnetic and conductive characteristics to the fluid. The coated magnetic particles are dispersed in a carrier fluid that gives the fluid viscosity, flow and vapor pressure properties.

Abstract translation: 介绍了导电超顺磁性液体胶体及其制备和使用方法。 磁性液体胶体含有涂覆有导电性有机金属化合物的磁性颗粒，其赋予流体磁性和导电特性。 涂覆的磁性颗粒分散在载体流体中，其赋予流体粘度，流动和蒸气压特性。

公开(公告)号：WO1992002940A1

公开(公告)日：1992-02-20

申请号：PCT/US1991005685

申请日：1991-08-09

Applicant: OMNI QUEST CORPORATION

Inventor： OMNI QUEST CORPORATION ,  CHAGNON, Mark, S. ,  HAMILTON, Tracy

IPC: H01F01/00

CPC classification number: B82Y30/00 ,  A61K49/1818 ,  B03C1/01 ,  B82Y5/00 ,  B82Y25/00 ,  C01G49/08 ,  C01P2004/51 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/42 ,  H01F1/0054 ,  H01F1/11 ,  H01F1/445

Abstract: A novel method for producing magnetic microparticles from metallocene is disclosed. The method involves combining an aqueous slurry of the metallocene and an aqueous slurry of a metal hydroxide and milling the slurries together. Fine magnetic particles are produced using the present method.

公开(公告)号：WO1990015666A1

公开(公告)日：1990-12-27

申请号：PCT/US1990003409

申请日：1990-06-15

Applicant: OMNI QUEST CORPORATION

Inventor： OMNI QUEST CORPORATION ,  CHAGNON, Mark, S. ,  FERRIS, John, R.

IPC: B03C01/00

CPC classification number: B03C1/01 ,  G01N33/5434 ,  G01N2400/26 ,  G01N2446/20 ,  G01N2446/84 ,  G01N2446/90

Abstract: Magnetically responsive particles and their use in systems in which the separation of certain molecules from the surrounding medium is necessary or desirable are disclosed. The magnetically responsive particles consist of a metal, metal oxide or metal alloy core, coated with a polymer having attached thereto an organic functionality to which a variety of organic and/or biological molecules can be coupled. The particles can be dispersed in aqueous media without rapid gravitational settling and conveniently reclaimed from the media using a magnetic field. The magnetically responsive particles of the invention may be coupled to biological or organic molecules with affinity for, or the ability to adsorb, or which interact with certain other biological or organic molecules. Particles so coupled may be used in a variety of in vitro or in vivo systems involving separation steps or the directed movement of coupled molecules to particular sites, including immunological assays, other biological assays, biochemical or enzymatic reactions, affinity chromatographic purification, cell sorting and diagnostic and therapeutic uses.

Abstract translation: 公开了磁响应性颗粒及其在某些分子与周围介质的分离是必要或期望的系统中的用途。 磁响应颗粒由金属，金属氧化物或金属合金芯组成，涂覆有附着有有机功能的聚合物，多种有机和/或生物分子可以偶合到其上。 颗粒可以分散在水介质中，而不需要快速重力沉降，并且可以方便地使用磁场从介质中回收。 本发明的磁响应性颗粒可以与生物或有机分子偶联，具有与某些其它生物或有机分子的亲和力或吸附能力或与之相互作用的生物或有机分子。 如此耦合的颗粒可用于涉及分离步骤的多种体外或体内系统或将偶联分子定向运动到特定位点，包括免疫测定，其他生物测定，生物化学或酶反应，亲和色谱纯化，细胞分选和 诊断和治疗用途。