公开(公告)号：WO2016161090A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/025228

申请日：2016-03-31

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： HAJIPOURAN BENAM, Kambez ,  NOVAK, Richard ,  SLIZ, Josiah ,  FERRANTE, Thomas, Charles ,  INGBER, Donald, Elliot ,  CHOE, Youngjae

IPC: C12N5/02 ,  C12N5/22 ,  C12M1/16 ,  C12M3/04 ,  G01N33/53

CPC classification number: G01N33/5064 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/14 ,  B01L2300/0861 ,  B01L2400/0478 ,  B01L2400/049 ,  C12M1/16 ,  C12M3/04 ,  C12M23/16 ,  C12M25/02 ,  C12M29/10 ,  C12M35/04 ,  F04B17/03 ,  F04B19/22 ,  F04B49/06

Abstract: A microfluidic system for determining a response of cells comprises one or more fluid pumps. The one or more fluid pumps move a fluid across cells within a microfluidic device. The microfluidic device includes a microchannel at least partially defined by a surface having cells adhered thereto, a first port at one end of the microchannel, and a second port at an opposing end of the microchannel. The one or more fluid pumps move the fluid across the cells in a first direction toward the second port and then move the fluid across the cells in a second direction toward the first port.

Abstract translation: 用于确定细胞响应的微流体系统包括一个或多个流体泵。 一个或多个流体泵移动流体跨过微流体装置内的细胞。 微流体装置包括至少部分地由附着有细胞的表面限定的微通道，微通道一端的第一端口和微通道的相对端处的第二端口。 一个或多个流体泵将流体沿着第一方向移动通过细胞朝向第二端口，然后使流体沿着第二方向朝着第一端口移动通过细胞。