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1.发明申请DEVICES, METHODS, AND COMPOSITIONS FOR RESTRICTING CELL POSITION AND STABILIZING CELLS IN CULTURE SYSTEMS 审中-公开用于限制培养系统中细胞位置和稳定细胞的装置，方法和组合物
公开(公告)号：WO2017116608A2
公开(公告)日：2017-07-06
申请号：PCT/US2016/064647
申请日：2016-12-02
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： HAJIPOURAN BENAM, Kambez , NOVAK, Richard , INGBER, Donald, E.
Abstract: A device is directed to simulating a function of a tissue, and includes a first structure defining a first chamber, a second structure defining a second chamber, and a porous membrane located at an interface region between the first chamber and the second chamber. The membrane has a first side facing toward the first chamber and a second side facing toward the second chamber, the membrane separating the first chamber from the second chamber. The first side includes a fluid-permeable, stimulus-responsive polymer gel thereon, the second side including at least one layer of cells adhered thereon.
Abstract translation: 一种装置涉及模拟组织的功能，并且包括限定第一腔室的第一结构，限定第二腔室的第二结构以及位于第一腔室和第二腔室之间的界面区域处的多孔膜， 室和第二室。 膜具有面向第一室的第一侧和面向第二室的第二侧，膜将第一室与第二室分隔开。 第一面在其上包括流体可渗透的刺激响应聚合物凝胶，第二面包括至少一层粘附在其上的细胞。
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公开(公告)号：WO2015138032A2
公开(公告)日：2015-09-17
申请号：PCT/US2014/071570
申请日：2014-12-19
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , FERNANDEZ-ALCON, Jose , WEN, Norman , NOVAK, Richard
Inventor： FERNANDEZ-ALCON, Jose , WEN, Norman , NOVAK, Richard , INGBER, Donald, E. , HAMILTON, Geraldine, A. , HINOJOSA, Christopher , DOMANSKY, Karel , LEVNER, Daniel , THOMPSON, II, Guy , HAJIPOURAN BENAM, Kambez , VILLENAVE, Remi , UMUNDUM, Thomas , PARIS, Alfred , BAUER, Georg
IPC: C12M3/02
CPC classification number: C12M23/16 , C12M21/08 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
Abstract translation: 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。 有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流动而将机械力施加到细胞。 有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。 有机模拟装置可以通过单独制造单独的部件来制造，例如，可以随后层压在一起的单独的层。
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Patent Agency Ranking3.发明申请METHODS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND/OR THERAPY MONITORING 审中-公开治疗慢性阻塞性肺疾病和/或治疗监测的方法
公开(公告)号：WO2016168565A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027700
申请日：2016-04-15
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： INGBER, Donald E. , HAJIPOURAN BENAM, Kambez , NOVAK, Richard
CPC classification number: C12Q1/6883 , A61K31/00 , C07K14/53 , C12Q2600/106 , C12Q2600/158 , G01N33/6863 , G01N33/6893 , G01N2800/52
Abstract: Described herein are methods for diagnosis and treatment of chronic obstructive pulmonary disease (COPD) exacerbation and/or therapy monitoring based in part on the level of macrophage colony-stimulating factor (M-CSF) expression and/or activity. Methods for diagnosis and treatment of COPD patients using novel molecular signature(s) are also provided. Methods for identifying subjects with COPD exacerbations who are more likely to be responsive to and benefit from a therapy that targets virus-induced exacerbations or non-infective COPD exacerbations are also described herein.
Abstract translation: 本文描述了部分基于巨噬细胞集落刺激因子（M-CSF）表达和/或活性水平的慢性阻塞性肺疾病（COPD）加重和/或治疗监测的诊断和治疗方法。 还提供了使用新型分子标记诊断和治疗COPD患者的方法。 本文还描述了用于鉴定更可能对靶向病毒引起的恶化或非感染性COPD恶化的治疗有益并受益于COPD恶化的受试者的方法。
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4.发明申请RESPIRATION DEVICE FOR ANALYSIS OF A RESPONSE TO SHEAR STRESS AND FOREIGN AGENTS ON CELLS 审中-公开用于分析剪切应力和外源细胞的响应的呼吸装置
公开(公告)号：WO2016161090A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025228
申请日：2016-03-31
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： HAJIPOURAN BENAM, Kambez , NOVAK, Richard , SLIZ, Josiah , FERRANTE, Thomas, Charles , INGBER, Donald, Elliot , CHOE, Youngjae
CPC classification number: G01N33/5064 , B01L3/502723 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2200/0689 , B01L2200/14 , B01L2300/0861 , B01L2400/0478 , B01L2400/049 , C12M1/16 , C12M3/04 , C12M23/16 , C12M25/02 , C12M29/10 , C12M35/04 , F04B17/03 , F04B19/22 , F04B49/06
Abstract: A microfluidic system for determining a response of cells comprises one or more fluid pumps. The one or more fluid pumps move a fluid across cells within a microfluidic device. The microfluidic device includes a microchannel at least partially defined by a surface having cells adhered thereto, a first port at one end of the microchannel, and a second port at an opposing end of the microchannel. The one or more fluid pumps move the fluid across the cells in a first direction toward the second port and then move the fluid across the cells in a second direction toward the first port.
Abstract translation: 用于确定细胞响应的微流体系统包括一个或多个流体泵。 一个或多个流体泵移动流体跨过微流体装置内的细胞。 微流体装置包括至少部分地由附着有细胞的表面限定的微通道，微通道一端的第一端口和微通道的相对端处的第二端口。 一个或多个流体泵将流体沿着第一方向移动通过细胞朝向第二端口，然后使流体沿着第二方向朝着第一端口移动通过细胞。
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5.发明申请
公开(公告)号：WO2017116608A3
公开(公告)日：2017-07-06
申请号：PCT/US2016/064647
申请日：2016-12-02
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： HAJIPOURAN BENAM, Kambez , NOVAK, Richard , INGBER, Donald, E.
Abstract: A device is directed to simulating a function of a tissue, and includes a first structure defining a first chamber, a second structure defining a second chamber, and a porous membrane located at an interface region between the first chamber and the second chamber. The membrane has a first side facing toward the first chamber and a second side facing toward the second chamber, the membrane separating the first chamber from the second chamber. The first side includes a fluid-permeable, stimulus-responsive polymer gel thereon, the second side including at least one layer of cells adhered thereon.
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公开(公告)号：WO2017096296A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064813
申请日：2016-12-02
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： HAJIPOURAN BENAM, Kambez , INGBER, Donald, E. , NOVAK, Richard
CPC classification number: C12M25/02 , B01L9/50 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B81C1/00 , C12M23/16 , C12M23/46 , G01N27/00
Abstract: A clamping system for a microfluidic device includes a compression plate engaging a side of a microfluidic device. A compression device provides compressive forces. The compression device is operatively connected to the compression plate such that the compressive forces create a substantially uniform pressure on the side of the microfluidic device.
Abstract translation: 用于微流体装置的夹紧系统包括接合微流体装置的一侧的压紧板。 压缩装置提供压缩力。 压缩装置可操作地连接至压缩板，使得压缩力在微流体装置的侧面上产生基本均匀的压力。
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7.发明申请LOW SHEAR MICROFLUIDIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开低剪切微流体器件及其使用方法和制造方法
公开(公告)号：WO2015138034A2
公开(公告)日：2015-09-17
申请号：PCT/US2014/071611
申请日：2014-12-19
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： INGBER, Donald E. , HAJIPOURAN BENAM, Kambez , VILLENAVE, Remi , HAMILTON, Geraldine A. , HASSELL, Bryan , HINOJOSA, Christopher D.
IPC: C12M3/02
CPC classification number: G01N33/5044 , B01L3/5027 , C12M21/08 , C12M23/16 , C12M25/02 , C12M35/04 , C12M41/46 , G01N2800/122
Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
Abstract translation: 本文提供了用于生产和使用具有被一个或多个膜分隔开的中央通道的主体的系统和方法。 膜（一个或多个）被配置为将中央通道分成至少一个中途通道和至少一个微通道。 中通道的高度实质上大于微通道的高度。 气态流体可以通过中孔道施加，而液态流体流过微型通道。 本文描述的系统和方法可以用于各种应用，包括例如原代细胞如人肺细胞的生长和分化，以及需要低剪切和/或分层结构的任何其他细胞，或者模拟微环境 活体组织和/或器官（以模拟生理或疾病状态，和/或识别治疗剂和/或疫苗）。 该系统和方法还可以允许与一种或多种不同细胞类型共培养。
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