中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

14 records (took 0.019 seconds)

    RAPID SYNTHESIS OF RADIOLABELED PYRIMIDINE NUCLEOSIDES OR NUCLEOTIDES
    7.
    发明申请
    RAPID SYNTHESIS OF RADIOLABELED PYRIMIDINE NUCLEOSIDES OR NUCLEOTIDES 审中-公开
    放射性联吡啶核苷或核苷酸的快速合成

    公开(公告)号：WO1996023806A1

    公开(公告)日：1996-08-08

    申请号：PCT/US1996001264

    申请日：1996-02-01

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  KASSIS, Amin, I. ,  FOULON, Catherine, F. ,  ADELSTEIN, S., James

    IPC: C07H19/06

    CPC classification number: A61K51/0491 ,  C07H19/06

    Abstract: A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, an aqueous solution (i) a radioactive iodide, bromide, chlorine or astatide ion and (ii) a water soluble halomercuri pyrimidine nucleoside or nucleotide is contacted with an oxidizing agent, whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.

    Abstract translation: 描述了制备放射性标记的嘧啶核苷或核苷酸的方法。 在该方法中，将水溶液（i）放射性碘化物，溴化物，氯或ast ide ide离子和（ⅱ）水溶性卤代核苷嘧啶核苷或核苷酸与氧化剂接触，由此将水溶性嘧啶核苷或放射性标记的核苷酸 形成碘，溴，氯或ast。。 还公开了适用于实施该方法的套件。

    METHOD OF MAKING RADIOIODINATED PYRIMIDINE
    8.
    发明申请
    METHOD OF MAKING RADIOIODINATED PYRIMIDINE 审中-公开
    制备放射性碘吡啶的方法

    公开(公告)号：WO1989007106A1

    公开(公告)日：1989-08-10

    申请号：PCT/US1989000358

    申请日：1989-01-27

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  KASSIS, Amin, I. ,  BARANOWSKA-KORTYLEWICZ, Janina

    IPC: C07H01/00

    CPC classification number: C07H19/06

    Abstract: The method of making radioiodinated pyrimidine nucleoside or nucleotide which comprises contacting a water-insoluble halomercuri pyrimidine nucleoside or nucleotide with an aqueous medium containing a dissolved radioactive iodide ion and an oxidizing agent, the molar amounts of said nucleoside or nucleotide and said oxidizing agent being in excess of the molar amount of said iodide, whereby water-soluble radioactive iodinated pyrimidine nucleoside or nucleotide is formed in solution, and separating residual water-insoluble halomercuri pyrimidine nucleoside or nucleotide from said solution.

    METHODS AND APPARATUS FOR ISOLATION OF WHITE BLOOD CELLS
    9.
    发明申请
    METHODS AND APPARATUS FOR ISOLATION OF WHITE BLOOD CELLS 审中-公开
    白细胞分离方法及装置

    公开(公告)号：WO2013155401A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/036353

    申请日：2013-04-12

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： KASSIS, Amin, I.

    IPC: A61M1/02 ,  A61J1/05 ,  B04B7/08 ,  B04B1/00

    CPC classification number: A61M1/3693 ,  A61J1/2037 ,  A61J1/2051 ,  A61J1/2096 ,  B01L3/5021 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2400/0644 ,  B04B5/0414

    Abstract: Kits and methods provide for the isolation of white blood cells from bodily fluids. In one exemplary aspect, a method for isolating white blood cells from blood includes the act of adding a blood sample to a separation tube having a distal end, a proximal end, and a valve located proximate said proximal end, said valve being configured to transition between at least first, second, and third positions. The method also includes the act of removably attaching a cap to the distal end, centrifuging the separation tube with the valve in the first position, removing the cap at the distal end of the separation tube and removably attaching a first syringe to the proximal end, switching the valve to the second position and withdrawing, via the first syringe, a red blood cell sediment. The method also includes the act of switching the valve to the first position and removing the first syringe, adding a small volume of buffer to the separation tube, removably attaching a cap to the distal end and centrifuging the separation tube and removing the cap at the distal end of the separation tube and removably attaching a second syringe to the proximal end. Additional acts include switching the valve to the second position, withdrawing the remaining red blood cell sediment via the second syringe and switching the valve to the first position and removing the second syringe.

    Abstract translation: 试剂盒和方法提供从体液中分离白细胞。 在一个示例性方面，用于从血液中分离白细胞的方法包括将血液样品添加到具有远端，近端和位于所述近端附近的分离管的分离管的动作，所述阀被配置为转变 在至少第一，第二和第三位置之间。 该方法还包括将帽可拆卸地附接到远端的动作，使分离管离心在第一位置，将分离管的远端处的帽移除并将第一注射器可拆卸地附接到近端， 将阀切换到第二位置，并通过第一注射器抽出红细胞沉积物。 该方法还包括将阀切换到第一位置并移除第一注射器的动作，向分离管添加少量缓冲液，将盖可拆卸地附接到远端并离心分离管并在 分离管的远端并将第二注射器可拆卸地附接到近端。 附加动作包括将阀切换到第二位置，通过第二注射器取出剩余的红细胞沉淀物并将阀切换到第一位置并移除第二注射器。

Patent Agency Ranking