公开(公告)号：WO2018163154A1

公开(公告)日：2018-09-13

申请号：PCT/IL2018/050231

申请日：2018-03-01

Applicant: PYTHAGORAS MEDICAL LTD.

Inventor： GROSS, Yossi ,  ZADOK, Yehuda ,  NEEMAN, Ronen

IPC: A61B18/14 ,  A61N1/05

Abstract: An elongate member (22) has a proximal portion and a distal portion. An extracorporeal controller (40) is coupled to the proximal portion of the elongate member, and includes a user interface (42) and control circuitry (44). An effector unit (30) is coupled to the distal portion of the elongate member, defines a longitudinal axis, and has a contracted state and an expanded state. The effector unit includes a plurality of electrodes (32) and an ultrasound transducer (34). The electrodes are operable by the control circuitry, and are disposed circumferentially around the central longitudinal axis of the effector unit. The ultrasound transducer is operable by the control circuitry. In the expanded state, each electrode is disposed further radially outward from (i) the central longitudinal axis of the effector unit, and (ii) the transducer compared to the contracted state, and the transducer is oriented to direct ultrasound radially outwardly.

公开(公告)号：WO2017199240A2

公开(公告)日：2017-11-23

申请号：PCT/IL2017/050533

申请日：2017-05-15

Applicant: PYTHAGORAS MEDICAL LTD.

Inventor： GROSS, Yossi ,  ZADOK, Yehuda ,  TAL, Yaron

IPC: A61B18/14

CPC classification number: A61B5/4893 ,  A61B5/0215 ,  A61B5/6852 ,  A61B5/6855 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/1467 ,  A61B2018/1497 ,  A61B2018/162 ,  A61B2018/165

Abstract: Apparatus comprises: (a) a longitudinal member (32), having a distal portion (34); (b) a plurality of electrodes (38) disposed on the distal portion of the longitudinal member, such that a first electrode (38a) of the plurality of electrodes is disposed distally along the longitudinal member from a second electrode (38b) of the plurality of electrodes; and (c) a controller (40). The controller comprises an actuator, and circuitry (42) electrically connected to the electrodes via the longitudinal member. The actuator is configured to move the longitudinal member in discrete incremental movements such that for each incremental movement, (i) before the incremental movement the first electrode is disposed in a starting position, (ii) during each incremental movement the actuator moves second electrode toward the starting position, and (iii) at the end of each incremental movement the second electrode is stationary at the starting position.

Abstract translation: 装置包括：（a）具有远端部分（34）的纵向构件（32）; （b）设置在所述纵向构件的所述远侧部分上的多个电极（38），使得所述多个电极中的第一电极（38a）沿着所述纵向构件从所述多个第二电极（38b）向远侧布置 电极; 和（c）控制器（40）。 控制器包括致动器以及经由纵向构件电连接到电极的电路（42）。 致动器构造成以不连续增量运动移动纵向构件，使得对于每次增量移动，（i）在增量移动之前，第一电极布置在起始位置，（ii）在每次增量移动期间，致动器使第二电极朝向 （iii）在每次增量移动结束时，第二电极在起始位置静止。

公开(公告)号：WO2018042432A1

公开(公告)日：2018-03-08

申请号：PCT/IL2017/050967

申请日：2017-08-30

Applicant: PYTHAGORAS MEDICAL LTD.

Inventor： GROSS, Yossi ,  ZADOK, Yehuda

IPC: A61B5/021 ,  A61B18/12 ,  A61B18/14 ,  A61N1/36

CPC classification number: A61B18/1233 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00761 ,  A61B2018/00845 ,  A61B2018/00886 ,  A61B2018/128

Abstract: Apparatus for use with a blood vessel (10) of a subject includes (a) a longitudinal member (92) that has a proximal portion and a distal portion, and includes an electrode (94, 124) disposed at the distal portion, the distal portion being transluminally advanceable to the blood vessel; and (b) a control unit (100), in electrical communication with the electrode, and comprising circuitry (102). The circuitry is configured to: (a) during a dual- signal period, drive the electrode to apply a dual electric signal that has (i) an excitation component that has a frequency of 20 - 500 Hz, and (ii) an ablation component that has a frequency of 5 kHz - 1 GHz; and (b) during an ablation-signal period that is separate from the dual-signal period, drive the electrode to apply an ablation electric signal that has the ablation component but not the excitation component. Other embodiments are also described.

Abstract translation: 用于对象的血管（10）的装置包括：（a）纵向构件（92），其具有近侧部分和远侧部分，并且包括电极（94,124） 设置在所述远侧部分处，所述远侧部分可透射地前进到所述血管; 和（b）控制单元（100），与电极电连通，并包括电路（102）。 该电路被配置为：（a）在双信号时段期间，驱动电极以施加具有（i）具有20-500Hz的频率的激励分量和（ii）消融分量 频率为5 kHz - 1 GHz; 和（b）在与双信号周期分开的消融信号周期期间，驱动电极以施加具有消融成分但不具有激励成分的消融电信号。 还描述了其他实施例。

公开(公告)号：WO2017199240A3

公开(公告)日：2017-11-23

申请号：PCT/IL2017/050533

申请日：2017-05-15

Applicant: PYTHAGORAS MEDICAL LTD.

Inventor： GROSS, Yossi ,  ZADOK, Yehuda ,  TAL, Yaron

IPC: A61B18/14 ,  A61B5/00 ,  A61B18/16 ,  A61B18/00

Abstract: Apparatus comprises: (a) a longitudinal member (32), having a distal portion (34); (b) a plurality of electrodes (38) disposed on the distal portion of the longitudinal member, such that a first electrode (38a) of the plurality of electrodes is disposed distally along the longitudinal member from a second electrode (38b) of the plurality of electrodes; and (c) a controller (40). The controller comprises an actuator, and circuitry (42) electrically connected to the electrodes via the longitudinal member. The actuator is configured to move the longitudinal member in discrete incremental movements such that for each incremental movement, (i) before the incremental movement the first electrode is disposed in a starting position, (ii) during each incremental movement the actuator moves second electrode toward the starting position, and (iii) at the end of each incremental movement the second electrode is stationary at the starting position.

公开(公告)号：WO2017125910A1

公开(公告)日：2017-07-27

申请号：PCT/IL2017/050029

申请日：2017-01-11

Applicant: PYTHAGORAS MEDICAL LTD.

Inventor： GROSS, Yossi ,  ZADOK, Yehuda

IPC: G06T7/00

CPC classification number: A61B18/1492 ,  A61B5/0215 ,  A61B5/0538 ,  A61B5/061 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6876 ,  A61B5/743 ,  A61B5/7435 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00988 ,  A61B2505/05 ,  G06F19/00

Abstract: A computer processor (52) that: (1) generates a map (101, 151) of vasculature of a subject, by: (a) displaying (i) a schematic representation of the vasculature including a blood vessel (102), and (ii) on the schematic representation, a first plurality of branch-site options (104, 154); (b) receiving a user-selected first branch site, and responsively displaying (i) a schematic representation of a first branch of the vasculature that branches from the schematic representation of the blood vessel at the user-selected first branch site, and (ii) a second plurality of branch-site options; and (c) receiving a user-selected second branch site; (2) responsively to receiving the user-selected second branch site, displays the map; (3) detects a physiological parameter of the subject; and (4) responsively to the detected physiological parameter, determines a value for the parameter, and stores, in association with a location on the map, data representative of the value.

Abstract translation: 一种计算机处理器（52），其：（1）通过以下步骤生成对象的脉管系统的图（101,151）：（a）显示（i）脉管系统的示意图，所述脉管系统包括 （ii）在所述示意图上，第一多个分支部位选项（104,154）;以及 （b）接收用户选择的第一分支部位，并且响应地显示（i）在用户选择的第一分支部位处从血管的示意图表分支的脉管系统的第一分支的示意性表示，以及（ii） ）第二多个分支站点选项; 和（c）接收用户选择的第二分支站点; （2）响应于接收用户选择的第二分支站点，显示地图; （3）检测对象的生理参数; （4）响应于检测到的生理参数，确定参数的值，并且与地图上的位置相关联地存储表示该值的数据。