公开(公告)号：WO2017093780A1

公开(公告)日：2017-06-08

申请号：PCT/IB2015/059219

申请日：2015-11-30

Applicant: RQMICRO AG

Inventor： SCHAFFHAUSER, Daniel ,  KESERUE, Hans-anton ,  AKEPSIMAIDIS, Georgios

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502776 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/043 ,  B01L2400/086

Abstract: A microfluidic device (1) comprising, a pallet, having a first surface (4a) and second, opposite, surface (4b); the first surface (4a) having defined therein, a main channel (5), and one or more inlet subsidiary channels (6a,6b) each of which is in fluid communication with the main channel (5) at a first junction (7) which is located at one end of the main channel (5), and corresponding one or more outlet subsidiary channels (8a,8b) each of which is in fluid communication with the main channel (5) at a second junction (9) which is located an second, opposite, end of the main channel (5); wherein the depth ('d') of the one or more inlet subsidiary channels (6a,6b) and the depth ('χ') of the one or more outlet subsidiary channels (8a,8b) is less than the depth ('f) of the main channel (5) so that there is step (106a,106b, 108a, 108b) defined at the first junction (7) and at the second junction (9);the second, opposite, surface (4b) having defined therein a groove (15) which can receive a means for generating a magnetic field, wherein the groove (15) is aligned with, and extends parallel to, the main channel (5). There is further provided a corresponding assembly and method of extracting ferromagnetic, paramagnetic and/or diamagnetic particles from a sample.

Abstract translation: 微流体装置（1），其包括具有第一表面（4a）和第二相对表面（4b）的托盘。 其中限定有第一表面（4a）的第一表面（4a），主通道（5）和一个或多个入口辅助通道（6a，6b），每个入口辅助通道在第一接头（7）处与主通道（5） 其位于主通道（5）的一端，以及相应的一个或多个出口辅助通道（8a，8b），每个辅助通道在第二接头（9）处与主通道（5）流体连通， 位于主通道（5）的第二相对端; 其中所述一个或多个入口辅助通道（6a，6b）的深度（'d'）和所述一个或多个出口辅助通道（8a，8b）的深度（'X'）小于所述深度（'f' ），从而在所述第一接合处（7）和所述第二接合处（9）处具有台阶（106a，106b，108a，108b）;所述第二相对表面（4b）具有限定在所述主通道 其中可以容纳用于产生磁场的装置的凹槽（15），其中凹槽（15）与主通道（5）对齐且平行于主通道（5）延伸。 还提供了从样品中提取铁磁性，顺磁性和/或反磁性颗粒的相应组件和方法。

公开(公告)号：WO2020157544A1

公开(公告)日：2020-08-06

申请号：PCT/IB2019/050792

申请日：2019-01-31

Applicant: RQMICRO AG

Inventor： SCHAFFHAUSER, Daniel ,  DELLMANN, Laurent ,  PERRAUDIN, Jonathan ,  LANGOUËT, Julien

IPC: G01N21/05 ,  B01L3/00

Abstract: According to the present invention there is provided a cartridge (1) comprising a channel (1a) along which a sample fluid can flow; one or more elements (3, 4) which are configured to manipulate light in a predefined manner, and wherein said one or more elements (3, 4) are located in a predefined position relative to the channel (la). There is further provided an assembly which comprises said cartridge (1) and an optical device (5) which can emit light; and a method of aligning the optical device (5) over the channel (la) of the cartridge (1) using said one or more elements (3, 4) so that when the optical device (5) emits light it will be incident on any sample fluid provided in the channel (1).

公开(公告)号：WO2017093781A1

公开(公告)日：2017-06-08

申请号：PCT/IB2015/059220

申请日：2015-11-30

Applicant: RQMICRO AG

Inventor： SCHAFFHAUSER, Daniel

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/082

Abstract: An interface component (40), suitable for cooperating with a microfluidic device (1), the interface component comprising, one or more elements (41) which can be selectively connected to a pneumatic system (71 a,71 b) which can provide a positive and/or negative air flow to the one or more elements (41); wherein each of the one or more elements (41) comprises, an input port (42) which can be selectively fluidly connected to a pneumatic system (71 a,71 b); and a flow restrictor (43) according to a further aspect of the present invention; the flow restrictor (43) being arranged in fluid communication with the input port (42), wherein the flow restrictor (43) can restrict the flow of fluid through the element (41); and an aerosol filter (49) which is arranged to be in fluid communication with the flow restrictor (43); and wherein the interface component (40) further comprises one or more outlets (45), each of the one or more outlets (45) being in fluid communication with a respective element (41), so that fluid can flow from the element (41) out of the interface component (40) via the one or more outlets (45); and wherein each of the one or more outlets (45) can be selectively arranged to be in fluid communication with a respective reservoir (105,106,107,108) of a microfluidic device (1). There is further provided a corresponding method and assembly for extracting ferromagnetic, paramagnetic and/or diamagnetic particles from a sample.

Abstract translation: 适于与微流体装置（1）配合的接口部件（40），所述接口部件包括一个或多个可选择性地连接到气动系统（71a）的元件（41） ，71b），其可以向所述一个或多个元件（41）提供正和/或负空气流; 其中所述一个或多个元件（41）中的每一个包括可选择性地流体连接至气动系统（71a，71b）的输入端口（42）; 和根据本发明的另一方面的限流器（43） 所述限流器（43）布置成与所述输入端口（42）流体连通，其中所述限流器（43）能够限制通过所述元件（41）的流体流动。 和布置成与限流器（43）流体连通的气溶胶过滤器（49）; 并且其中所述界面部件（40）还包括一个或多个出口（45），所述一个或多个出口（45）中的每一个与相应的元件（41）流体连通，使得流体可以从所述元件（41 ）通过所述一个或多个出口（45）流出所述界面部件（40）; 并且其中所述一个或多个出口（45）中的每一个可被选择性地布置成与微流体装置（1）的相应贮存器（105,106,107,108）流体连通。 还提供了用于从样品中提取铁磁性，顺磁性和/或反磁性颗粒的相应方法和组件。