公开(公告)号：WO2013070961A1

公开(公告)日：2013-05-16

申请号：PCT/US2012/064217

申请日：2012-11-08

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  LOOKER, Adam ,  LITTLER, Benjamin, Joseph ,  CHOUDHURY, Anusuya ,  HARRISON, Cristian ,  VELURI, Ravikanth ,  RYAN, Michael, P. ,  JIANG, Licong ,  LUSS-LUSIS, Eduard

Inventor： LOOKER, Adam ,  LITTLER, Benjamin, Joseph ,  CHOUDHURY, Anusuya ,  HARRISON, Cristian ,  VELURI, Ravikanth ,  RYAN, Michael, P. ,  JIANG, Licong ,  LUSS-LUSIS, Eduard

IPC: C07D405/12 ,  C07D405/14 ,  C07D498/04 ,  A61K31/405 ,  A61K31/553 ,  A61P27/00 ,  A61P11/00 ,  A61P1/00 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00

CPC classification number: A61K31/553 ,  A61K31/404 ,  C07D267/14 ,  C07D405/12 ,  C07D405/14 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2020206119A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/026384

申请日：2020-04-02

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  RYAN, Michael, P.

Inventor： RYAN, Michael, P.

IPC: C07F9/576

Abstract: The present application is directed to a process of preparing compounds of formula I, and intermediates thereof as well as pharmaceutically acceptable salts, wherein R 2 , R 3 , R 5 , R 7 and X are defined herein. The compounds formula I inhibit sodium channels are useful for treating disorders, e.g. pain.

公开(公告)号：WO2017127517A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014093

申请日：2017-01-19

Applicant: RYAN, Michael, P.

Inventor： RYAN, Michael, P.

IPC: B27B33/14 ,  B23D57/02 ,  B27B17/00 ,  B27B17/02 ,  B27B33/00

CPC classification number: B27B33/14 ,  B23D61/021 ,  B23D61/121 ,  B23D61/126 ,  B27B33/00 ,  B27B33/142 ,  B27B33/145

Abstract: The present invention relates to a novel catting apparatus capable of effectively cutting a material via movement in at least two different directions. In certain embodiments, the cutting apparatus comprises cutting elements with at least two cutting surfaces. Such cutting elements are capable of effectively penetrating a material when moved with an applied force in the direction that at least one cutting surface is oriented. Such cutting elements may be configured for use with a variety of cutting apparatus, including but not limited to chainsaws, circular saws, band saws, jigsaws or tigersaws.

Abstract translation: 本发明涉及一种能够通过在至少两个不同方向上的运动有效地切割材料的新型捕捉装置。 在某些实施例中，切割设备包括具有至少两个切割表面的切割元件。 当在至少一个切割表面被定向的方向上用施加的力移动时，这种切割元件能够有效地穿透材料。 这种切割元件可以被配置为与各种切割设备一起使用，包括但不限于链锯，圆锯，带锯，竖锯或虎锯。

公开(公告)号：WO2010093890A2

公开(公告)日：2010-08-19

申请号：PCT/US2010/024054

申请日：2010-02-12

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  ROEPER, Stefanie ,  LOOKER, Adam, R. ,  MARTINOT, Theodore, A. ,  NEUBERT-LANGILLE, Bobbianna ,  RYAN, Michael, P. ,  SNOONIAN, John, R.

Inventor： ROEPER, Stefanie ,  LOOKER, Adam, R. ,  MARTINOT, Theodore, A. ,  NEUBERT-LANGILLE, Bobbianna ,  RYAN, Michael, P. ,  SNOONIAN, John, R.

IPC: C07D213/80 ,  C07D213/803 ,  A61K31/4418 ,  A61P37/06 ,  A61P29/00

CPC classification number: C07D213/80 ,  C07D213/803

Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(l-(phenyl)ureido)nicotinamides in high purity and yields.

Abstract translation: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。

公开(公告)号：WO2021178940A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/021269

申请日：2021-03-06

Applicant: RYAN, Michael, P.

Inventor： RYAN, Michael, P.

IPC: C12H1/22

Abstract: The present invention is related to the accelerated aging of spirits through a centrally deposed, substantially vertically placed insert in a volume of spirits or alcohol. The insert may be a segment of charred wood, namely oak, in a specific volume and percentage of ethyl alcohol containing liquid. The present invention's novelty is a result of the vertical orientation of said insert of charred wood and the realized effects of such placement wherein a number of physical and chemical reactions occur as a result of specific interactions between alcohol and air trapped within the wood. The resulting comingling of wood and alcohol containing liquid facilitates release of certain coloring and flavor components, leaching from the wood and into the surrounding liquid, which leads to a hastening of the aging process.

公开(公告)号：WO2010108162A1

公开(公告)日：2010-09-23

申请号：PCT/US2010/028069

申请日：2010-03-19

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  DEMATTEI, John ,  LOOKER, Adam, R. ,  NEUBERT-LANGILLE, Bobbianna ,  TRUDEAU, Martin ,  ROEPER, Stefanie ,  RYAN, Michael, P. ,  YAP, Dahrika, Milfred Lao ,  KRUEGER, Brian, R. ,  GROOTENHUIS, Peter, D.J. ,  VAN GOOR, Frederick, F. ,  BOTFIELD, Martyn, C. ,  ZLOKARNIK, Gregor

Inventor： DEMATTEI, John ,  LOOKER, Adam, R. ,  NEUBERT-LANGILLE, Bobbianna ,  TRUDEAU, Martin ,  ROEPER, Stefanie ,  RYAN, Michael, P. ,  YAP, Dahrika, Milfred Lao ,  KRUEGER, Brian, R. ,  GROOTENHUIS, Peter, D.J. ,  VAN GOOR, Frederick, F. ,  BOTFIELD, Martyn, C. ,  ZLOKARNIK, Gregor

IPC: C07D215/233

CPC classification number: C07C205/43 ,  C07C68/02 ,  C07C69/96 ,  C07C201/08 ,  C07C213/02 ,  C07C229/66 ,  C07D215/233 ,  C07D215/56 ,  G01N33/5041 ,  G01N33/6872 ,  Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

Abstract translation: 本发明提供了制备式1化合物的方法; 包括偶联式2的羧酸; 与式3的苯胺; 在偶联剂存在下。