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公开(公告)号：WO2012109249A3
公开(公告)日：2012-08-16
申请号：PCT/US2012/024152
申请日：2012-02-07
Inventor： GOLUB, Charles S. , TZIVANIS, Michael J. , ZOELLNER, Clemens E. , SNYDER, Mitchell L. , COLTON, Mark F. , OU, Duan Li
Abstract: A flexible article includes a layer of a thermoplastic polyurethane composition including a plasticizer present at up to about 50.0% by weight of the total weight of the composition. The thermoplastic polyurethane composition has a shore A durometer of not greater than about 80. A method of making a flexible article includes combining a thermoplastic polyurethane with a plasticizer to form a thermoplastic polyurethane composition, wherein the plasticizer is present at up to about 50.0% by weight of the total weight of the composition; and forming the thermoplastic polyurethane composition into the flexible article, wherein the flexible article has a shore A durometer of not greater than about 80.
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公开(公告)号：WO2021257652A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037553
申请日：2021-06-16
Inventor： ZOELLNER, Clemens E. , NIXON, Thomas, R. , WHEATLEY, Jonathon
IPC: C12M1/26 , B01L13/00 , B01L2300/042 , B01L2300/168 , B01L2400/0406 , B01L2400/06 , B01L3/0293 , B01L3/502 , C12M23/22 , C12M23/28 , C12M23/38 , C12M33/04 , C12M37/00 , G01N1/10 , G01N1/14 , G01N2001/1427 , G01N2001/205 , G01N2001/2078
Abstract: The present application is directed to a sampling system for sampling a fluid from a vessel, where the sampling system includes a sterile dispenser assembly operatively connected to the vessel, the sterile dispenser assembly including a valve operatively connected to the vessel, a membrane, and a needle, and a detachable sterile sampling container assembly operatively connected to the sterile dispenser assembly, the detachable sterile sampling container assembly including a sampling container, a membrane attached to the sampling container, and a sampling container housing enclosing the sampling container, where the sampling container housing includes a compressible portion having a deflated configuration and an expanded configuration.
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公开(公告)号：WO2020102279A1
公开(公告)日：2020-05-22
申请号：PCT/US2019/061085
申请日：2019-11-13
Inventor： WERTH, Albert A. , ZOELLNER, Clemens E.
Abstract: A valve comprising: a valve body; and a valve stem disposed at least partially within the valve body, the valve stem comprising a sidewall defining a central lumen and at least one opening in the sidewall, wherein the valve is adapted to prevent fluid flow through the lumen when the at least one opening is disposed within the valve body and permit fluid flow through the lumen when the at least one opening is exposed from the valve body, and wherein the valve is essentially free of a spring.
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公开(公告)号：WO2021188261A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/019197
申请日：2021-02-23
Inventor： ZHANG, Jianfeng , PYTEL, Rachel Z. , DING, Jian L. , PAGLIARO, Anthony P. , ZOELLNER, Clemens E.
IPC: B29C65/02 , A61L2/14 , B29D23/00 , A61M25/00 , B29K221/00
Abstract: Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.
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Patent Agency Ranking
公开(公告)号：WO2019075285A1
公开(公告)日：2019-04-18
申请号：PCT/US2018/055546
申请日：2018-10-12
Inventor： ZOELLNER, Clemens E. , OSENTOSKI, Jason
Abstract: A fluid manifold may include a body that may include a proximal end, a distal end, and a primary manifold component extending from the proximal end of the body to the distal end of the body and enclosing a primary channel. The fluid manifold may further include at least one auxiliary manifold component diverging from the primary manifold component and enclosing an auxiliary channel connected to the primary channel at a primary channel exit port. The fluid manifold may further include at least one compression valve region disposed along the body of the manifold where the compression valve region may be operable between an open position and a closed position.
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公开(公告)号：WO2022147441A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/073141
申请日：2021-12-28
Inventor： NIXON, Thomas R. , ZOELLNER, Clemens E. , OSENTOSKI, Jason , MARTELL, Joshua
Abstract: The present application is directed to a packaging container including a body including; a first portion including a coupling feature; a second portion including a coupling feature and complementary to the first portion; and a hinge portion coupling the first portion to the second portion adapted to move the packaging container from an open position to a closed position around a product, where the first portion and the second portion combine to form a void port in the closed position.
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公开(公告)号：WO2021118780A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/061198
申请日：2020-11-19
Inventor： ZHANG, Jianfeng , PYTEL, Rachel Z. , PAGLIARO, Anthony P. , ZOELLNER, Clemens E. , DING, Jian L. , NIXON, Thomas R.
IPC: B29C65/10 , B29C37/00 , B29K21/00 , B29K101/12
Abstract: Systems and methods are disclosed that include generating a plasma treatment and applying the plasma treatment to end contact surfaces of a first profile and a second profile in a sterile environment, manipulating at least one of the first profile and the second profile to force contact between the end contact surface of the first profile and the end contact surface of the second profile to permanently connect, join, or weld the end contact surfaces of the first profile and the second profile together, thereby forming a sterile connection between the first profile and a second profile.
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公开(公告)号：WO2018169856A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/021982
申请日：2018-03-12
Inventor： RUPKALVIS, Janelle M. , ZOELLNER, Clemens E. , ALLEN, Casey S. , DOLLEN, Sandra L. , DAMZYN, David J.
IPC: B29C45/14
Abstract: A method of making a fluid manifold may include the use of a mold, a mandrel, and a distal support. A fluid manifold may include a primary channel, a plurality of secondary channels, and a distal channel, and the primary channel may be coterminous with the distal channel.
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公开(公告)号：WO2015175943A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/031084
申请日：2015-05-15
Inventor： SNYDER, Mitchell L. , ZOELLNER, Clemens E. , NIXON, Thomas R.
IPC: C12M3/02
CPC classification number: C12M23/04 , B01L3/0289 , B01L3/527 , B01L3/563 , B01L9/00 , B01L9/06 , C12M23/40 , C12M23/54 , C12M29/00
Abstract: A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB > AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.
Abstract translation: 适用于制造药物的制造制品，其包含托盘，所述托盘包括具有顶表面的基底; 以及从所述基座的顶表面延伸的歧管，所述歧管包括侧壁和上表面，所述上表面还包括通道，其中，当从所述顶表面观察时，所述基部具有面积AB，所述上表面 所述歧管具有面积AM和AB> AM，并且其中所述底座适于支撑各自容纳流体的多个容器。
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