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公开(公告)号:WO2022076581A2
公开(公告)日:2022-04-14
申请号:PCT/US2021/053801
申请日:2021-10-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor: O'BOYLE, Duncan A. , GRIFFITH, Linda , TRUMPER, David
IPC: C12M3/06 , C12M1/34 , C12M1/00 , B01L3/00 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/16 , B01L2300/042 , B01L2300/069 , B01L2300/0816 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0655 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/50 , B01L9/527 , B29C65/16 , C12M23/16 , C12M29/00 , C12M41/40 , F16K99/00
Abstract: Materials and methods of making have been developed for mass production of thermoplastic microfluidic chips. An elastomer diaphragm with a stress relieving feature can be used in microfluidic valves, pump diaphragms, and diaphragm micropumps. An optimized pump chamber design for complete fluid displacement and chamber geometry are provided. Microfluidic pressure regulators use a pneumatically actuated elastic membrane in a back-pressure regulator configuration. Microfluidic accumulators store pressurized fluid in a microfluidic chip. Removable caps for cell culture and a quick release top are described. Methods to incorporate hydrogels and ECM scaffolds have been developed. Electro pneumatic manifolds connect and control of multiple microfluidic devices vertically or on a rotary mechanism.
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公开(公告)号:WO2021259710A1
公开(公告)日:2021-12-30
申请号:PCT/EP2021/066145
申请日:2021-06-15
Inventor: GUERCIO, Giorgio
IPC: A61B10/00 , B01L3/00 , B65D51/28 , A61B10/0096 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2300/042 , B01L2300/047 , B01L2300/0672 , B01L2300/0832 , B01L2300/0858 , B01L2300/0867 , B01L3/502 , B01L3/523 , B65D51/2835
Abstract: A biopsy container assembly (1) comprises: a container (2) with a lower chamber (C1) suitable for containing a buffer liquid (L1), a cap (4) coupled with the container (2); the cap being provided with a chamber (C3) that contains a biopsy liquid (L2) sealed by means of a membrane (5), and a crown (3) with a toothing (33) suitable for tearing off said membrane (5) of the cap; the crown (3) being also suitable for being disposed in the container in an initial position, wherein the toothing (33) is directed downwards in order not to interfere with the membrane (5) of the cap when the cap is closed on the container, and in an operating position, wherein the toothing (33) is directed upwards in order to tear off the membrane (5) of the cap when the cap is closed on the container.
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公开(公告)号:WO2021250359A1
公开(公告)日:2021-12-16
申请号:PCT/FR2021/051048
申请日:2021-06-11
Applicant: BIOMÉRIEUX
Inventor: GUY, Michel , DELEPAUT, Nicolas
IPC: B01L99/00 , B67B7/00 , B01L3/00 , B01L2200/0689 , B01L2300/042 , B01L3/50853 , B01L3/50855 , B67B7/10
Abstract: L'objet de l'invention concerne un outil pour manipuler une pluralité de bouchons, se présentant sous la forme d'un peigne (1) comprenant : - un corps (7) muni d'une rangée de dents (4) possédant des parties distales pointues (4p) espacées selon une direction linéaire pour coopérer avec les cavités des bouchons; - un système de séparation des bouchons par rapport aux dents (4) comportant un tiroir rappelé élastiquement et guidé en coulissement par rapport au corps (7) selon une direction parallèle à la direction d'extension des dents, le tiroir étant pourvu des doigts du peigne, déplaçables en coulissement entre les dents (4) et une commande (lia) accessible à partir d'une première partie (la) du peigne et dont un appui en translation, assure le coulissement des doigts du peigne en direction des parties distales pointues (4p) pour éjecter les bouchons des dents (4).
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公开(公告)号:WO2022006216A1
公开(公告)日:2022-01-06
申请号:PCT/US2021/039791
申请日:2021-06-30
Applicant: IDEXX LABORATORIES, INC.
Inventor: GRIFFIN, Justin , PALME, John
IPC: B01L3/00 , A61B10/00 , B01L3/02 , B01L3/14 , A61B10/0038 , A61B10/0096 , B01L2200/026 , B01L2200/0668 , B01L2300/042 , B01L2300/046 , B01L3/0224 , B01L3/50215 , B01L3/508
Abstract: A collection device for examining fecal matter to determine whether or not a patient is afflicted with parasites includes a particle accumulating plug mounted on an end of a collection tube containing a fecal specimen. The particle accumulating plug includes a conically-shaped inner wall that defines an inverted funnel within the plug. A pipetting port is formed through the inner wall at the apex of the inverted funnel to allow the tip of a pipette to enter the port and aspirate the ova or eggs, or other parasite cells, that have separated from the fecal specimen when a flotation solution is added to the tube and the tube is centrifuged. The conical shape of the inner wall of the plug directs the separated parasite ova or eggs towards the pipetting port and to accumulate within the volume of the funnel of the plug.
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公开(公告)号:WO2021250672A2
公开(公告)日:2021-12-16
申请号:PCT/IL2021/050697
申请日:2021-06-10
Applicant: SALIGNOSTICS LTD.
Inventor: DEUTSCH, Omer , COHEN, Raluca , NEUMANN, Yoav , KRIEF, Guy
IPC: G01N33/53 , G01N33/543 , B01L3/00 , C12M1/26 , C12M1/28 , B01L2300/042 , B01L2300/0681 , B01L2400/0481 , B01L3/5023 , G01N33/5302
Abstract: An apparatus includes an elongate barrel (162), shaped to define a channel (164) therethrough, in which a porous carrier (170), that holds a surfactant (172), is disposed. A sponge (130) is coupled to the distal portion (124) of a plunger (122) that is dimensioned to slide snugly within the channel. While the sponge holds saliva, sliding of the plunger through the channel compresses the sponge within the channel. Compression of the sponge within the channel drives at least a portion of the saliva: (i) out of the sponge and through the carrier, and (ii) from the carrier, together with at least a portion of the surfactant, into a collection tube (180) that is reversibly couplable to an outlet (168) at a distal region of the channel. Other embodiments are also described.
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公开(公告)号:WO2021250360A1
公开(公告)日:2021-12-16
申请号:PCT/FR2021/051049
申请日:2021-06-11
Applicant: BIOMÉRIEUX
Inventor: GUY, Michel , DELEPAUT, Nicolas
IPC: B01L9/06 , B65D25/10 , B01L2200/026 , B01L2200/028 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L3/0275 , B01L3/5082
Abstract: L'invention concerne un dispositif comprenant : - un plateau (7) de support pour des tubes recevant des échantillons à analyser, ce plateau (7) présentant des trous (8) adaptés pour recevoir chacun un tube en appui sur la surface supérieure et avec son fond faisant saillie du plateau; - un couvercle (10) muni de cheminées (11) aménagées selon une répartition similaire à la répartition des trous du plateau, ce couvercle (10) étant conçu pour occuper au moins une position de superposition au-dessus du plateau (7), de manière que le couvercle puisse être assemblé de manière amovible au plateau pour former un ensemble unitaire de maintien des tubes et positionner les cheminées (11) au-dessus des tubes pour servir au guidage des embouts de pipettes pénétrant à l'intérieur des tubes.
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公开(公告)号:WO2021026249A8
公开(公告)日:2021-02-11
申请号:PCT/US2020/045030
申请日:2020-08-05
Applicant: BD KIESTRA B.V.
Inventor: FEIJEN, Franciscus, Hermannus , ARMSTRONG, Robert, Edward , LENTZ, Ammon, David , POHL, Brent, Ronald
IPC: C12M1/00 , C12M1/26 , B01L3/02 , B01L2200/0684 , B01L2300/042 , B01L2300/0672 , B01L2400/049 , B01L3/5635 , C12M33/04
Abstract: A multi-port disposable device that can both vent a sealed culture vessel and draw a sample therefrom into a collection vessel. The multi-port disposable device has a first port configured to receive the top portion of a culture vessel and attach thereto. The multi-port disposable device has a second port configured to receive a sample collection vessel. The multi-port disposable device has first and second needles. The first needle has a cannula configured to penetrate a septum or cap of the culture vessel. Optionally, the cannula terminates in a layer of foam that carries a microbial agent such that any vapor that is transmitted from the culture vessel through the cannula when venting the sealed culture vessel is absorbed by the foam. Optionally, the ports of the disposable device are configured as sleeves. The sleeve of the first port receives a portion of the culture vessel and the sleeve of the second port receives the collection vessel. The second needle has a cannula that penetrates both the septum or cap of the culture vessel and the septum or cap of the collection vessel, when the culture vessel and the collection vessel are brought into the device, thereby providing for fluid communication between the culture vessel and the collection vessel. The second cannula provides the flow pathway for delivering sample from the culture vessel to the collection vessel.
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公开(公告)号:WO2023059183A1
公开(公告)日:2023-04-13
申请号:PCT/NL2022/050551
申请日:2022-10-03
Applicant: MICRONIT HOLDING B.V.
Inventor: BLOM, Marko Theodoor , VAN 'T OEVER, Ronny , CONDE, Alvaro Jose
IPC: B01L3/00 , B01L2200/0621 , B01L2200/0642 , B01L2200/0684 , B01L2300/042 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , B01L3/502738 , B01L3/502746
Abstract: Microfluidic device comprising a microfluidic circuit comprising a main fluid channel and an inlet coupled to the main fluid channel for introducing fluid into the microfluidic circuit and at least one fluid chamber configuration, wherein the fluid chamber configuration comprises: - at least one fluid chamber; - a fluid chamber inlet channel coupling the main fluid channel to an inlet of the fluid chamber; - a fluid chamber outlet channel coupled to an outlet of the fluid chamber; - a pressure stop valve arranged in the main fluid channel downstream of the coupling with the fluid chamber inlet channel, wherein the pressure stop valve is arranged to block fluid at a pressure below a first burst pressure; - a flow restrictor arranged in the fluid chamber outlet channel, wherein the flow restrictor is arranged to provide a back pressure which is higher than the first burst pressure of the pressure stop valve.
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公开(公告)号:WO2023278111A1
公开(公告)日:2023-01-05
申请号:PCT/US2022/032667
申请日:2022-06-08
Applicant: XCALIBER SCIENCES, INC.
Inventor: MOTADEL, Arta
IPC: B01L3/02 , B01L9/00 , B01L2200/025 , B01L2200/026 , B01L2200/0689 , B01L2200/14 , B01L2200/141 , B01L2300/041 , B01L2300/042 , B01L2300/0816 , B01L2300/123 , B01L3/0275 , B01L3/0279 , B01L3/0286 , B01L9/543
Abstract: The system includes a pipette tip with a proximal end that has a rim. The rim defines a proximal opening adapted to receive a pipetter, and the rim includes a rim conical edge. The system also has a support card with a top surface, a pipette tip receiver opening within the top surface, the opening adapted to receive the pipette tip, and the opening has a receiver opening conical edge. The rim conical edge and the receiver conical edge are constructed such that when the pipette tip is disposed of in the pipette tip receiver opening, the rim conical edge abuts the receiver opening conical edge, and the top surface is flush with or nearly flush with than the rim.
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公开(公告)号:WO2023277245A1
公开(公告)日:2023-01-05
申请号:PCT/KR2021/012125
申请日:2021-09-07
Applicant: 에스디바이오센서 주식회사
IPC: B01L3/00 , C12M1/00 , C12N15/10 , B01L2200/021 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/044 , B01L2300/0609 , B01L2300/0672 , B01L2300/0854 , B01L2400/0478 , B01L2400/0644 , B01L3/502 , B01L3/502715 , B01L3/527 , B01L3/565 , B01L9/50 , C12N15/1017
Abstract: 본 발명은 외측 챔버와 내측 챔버의 이중 챔버 구조가 적용된 유전체 추출 장치에 관한 것으로, 전술한 이중 챔버 구조가 적용됨에 따라 시약 유출 위험 없이 장기간 안정적으로 보관이 가능한 유전체 추출 장치를 제공한다.
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