摘要:
Disclosed are compositions and methods that provide synthetic nanocarriers that comprise hydrophobic polyester carrier material and rapamycin that is in a stable, super- saturated amount. In some embodiments, the synthetic nanocarriers are also intially sterile filterable. In other embodiments, the rapamycin is present in the synthetic nanocarrier compositions in an amount that is less than 50 weight% rapamycin/hydrophobic polyester carrier material in the composition.