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    PHARMACEUTICAL AND OTHER PACKAGING WITH LOW OXYGEN TRANSMISSION RATE
    4.
    发明申请
    PHARMACEUTICAL AND OTHER PACKAGING WITH LOW OXYGEN TRANSMISSION RATE 审中-公开
    具有低氧传输速率的药物和其他包装

    公开(公告)号：WO2017031354A2

    公开(公告)日：2017-02-23

    申请号：PCT/US2016/047622

    申请日：2016-08-18

    Applicant: SIO2 MEDICAL PRODUCTS, INC.

    Inventor： WILLS, Matthew ,  TAHA, Ahmad ,  WEIKART, Christopher

    IPC: C23C16/04 ,  C23C16/40 ,  C23C16/30 ,  C23C16/515 ,  A61L31/08 ,  A61J1/05

    CPC classification number: C23C16/045 ,  A61L27/34 ,  A61L29/085 ,  A61L31/06 ,  C23C16/30 ,  C23C16/401 ,  C23C16/515 ,  C08L83/04

    Abstract: Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (289), a barrier coating or layer (288), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure.

    Abstract translation: 通过等离子体增强的化学气相沉积来处理抽空的血液样本收集管或其他容器以施加粘结涂层或层（289），阻挡涂层或层（288）以及任选的一个或多个另外的涂层或层。 在部分真空下施加SiO xCy的连接涂层或层，并且在保持腔内部分真空的同时，施加阻挡涂层或层。 然后任选地，在保持腔内部分真空的同时，可以施加pH保护涂层或SiOxCy层。 作为该处理的结果，生产具有比通过相同方法制造的对应容器更低的内腔气体渗透速率常数的涂覆容器，除了在施加粘结涂层或层之间打破管腔中的部分真空并施加屏障 涂层或层。 还描述了保持特征，用于在暴露于降低的环境压力期间保持容器塞住。

    PLASMA TREATMENT WITH NON-POLYMERIZING COMPOUNDS THAT LEADS TO REDUCED BIOMOLECULE ADHESION TO THERMOPLASTIC ARTICLES
    5.
    发明申请
    PLASMA TREATMENT WITH NON-POLYMERIZING COMPOUNDS THAT LEADS TO REDUCED BIOMOLECULE ADHESION TO THERMOPLASTIC ARTICLES 审中-公开
    引导减少生物分子粘附到热塑性物品的非聚合化合物的等离子体处理

    公开(公告)号：WO2016100557A2

    公开(公告)日：2016-06-23

    申请号：PCT/US2015/066169

    申请日：2015-12-16

    Applicant: SIO2 MEDICAL PRODUCTS, INC.

    Inventor： TAHA, Ahmad ,  FELTS, John T.

    IPC: C08J7/12

    CPC classification number: C08J7/123 ,  C08J2323/12 ,  C12M23/20

    Abstract: A method is provided for treating a surface of a substrate. The method includes treating the surface with plasma comprising one or more non-polymerizing compounds. The converted surface has a biomolecule recovery percentage greater than the biomolecule recovery percentage of the surface prior to treatment according to the method.

    Abstract translation: 提供了一种处理基材表面的方法。 该方法包括用包含一种或多种非聚合化合物的血浆处理表面。 根据该方法，经转化的表面的生物分子恢复百分比大于处理前的表面的生物分子恢复百分比。

    BIODEGRADABLE AND COMPOSTABLE VESSELS, SUCH AS COFFEE PODS, COATED WITH PECVD COATINGS OR LAYERS
    7.
    发明申请
    BIODEGRADABLE AND COMPOSTABLE VESSELS, SUCH AS COFFEE PODS, COATED WITH PECVD COATINGS OR LAYERS 审中-公开

    公开(公告)号：WO2020206384A1

    公开(公告)日：2020-10-08

    申请号：PCT/US2020/026756

    申请日：2020-04-03

    Applicant: SIO2 MEDICAL PRODUCTS, INC.

    Inventor： TAHA, Ahmad ,  BREELAND, Adam

    IPC: B65D65/46 ,  C23C16/04 ,  C23C16/40

    Abstract: Embodiments of the present disclosure are directed to a vessel comprising a wall at least partially made of a compostable or biodegradable material, having an interior surface enclosing a lumen and an exterior surface; and a PECVD coating set on the interior surface, the exterior surface, or both. The PECVD coating set comprises a barrier coating or layer of SiOx, in which x is from about 1.5 to about 2.9 as measured by XPS. The PECVD coating set optionally further comprises a tie coating or layer comprising SiOxCy, in which x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3 as measured by X-ray photoelectron spectroscopy (XPS); a pH protective coating or layer comprising SiOxCy, in which x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3 as measured by XPS; or both. The vessel may also include a lacquer coating between the surface of the wall and the PECVD coating set. In some embodiments, the vessel may be a single use coffee or tea pod.

    POLYMER PROCESS BAGS AND METHODS FOR MANUFACTURING THE SAME
    8.
    发明申请
    POLYMER PROCESS BAGS AND METHODS FOR MANUFACTURING THE SAME 审中-公开

    公开(公告)号：WO2020146433A1

    公开(公告)日：2020-07-16

    申请号：PCT/US2020/012638

    申请日：2020-01-07

    Applicant: SIO2 MEDICAL PRODUCTS, INC.

    Inventor： TAHA, Ahmad ,  BUCHOLTZ, Michael ,  ABRAMS, Robert S.

    IPC: A61J1/10 ,  A61J1/14 ,  C23C16/40

    Abstract: A pharmaceutical package comprises a polymeric wall having an interior surface and an outer surface; and a tie coating of SiOxCy and/or a barrier coating of SiOx and/or a protective coating of SiOxCy on the interior surface. The walls may be formed into the vessel by means of laser welding. The package can be, for example, a rigid container, a bioprocessing bag or a transfer bag, wherein the coatings afford improved barrier properties and/or are effective to block extractables/leachables from the substrate and any coatings thereon and the coatings are able to maintain their desirable characteristics described herein against stretching/elongation conditions. The bag or rigid container can be used in the entire process of the CAR T cell manufacture/therapy. A method of handling the coated packages comprises limiting stretching the packages. The method of monitoring or controlling the internal pressure of the coated packages is also described.

    POLYMERIC CELL CULTURING SURFACE HAVING HIGH CELL ADHESION
    10.
    发明申请
    POLYMERIC CELL CULTURING SURFACE HAVING HIGH CELL ADHESION 审中-公开

    公开(公告)号：WO2020036617A1

    公开(公告)日：2020-02-20

    申请号：PCT/US2018/064617

    申请日：2018-12-07

    Applicant: SIO2 MEDICAL PRODUCTS, INC.

    Inventor： TAHA, Ahmad ,  MAURER, Brian ,  WILLS, Matthew

    IPC: C12M1/00 ,  C12M3/04 ,  C08J7/12 ,  C12M1/24 ,  C12M1/12

    Abstract: A polymeric substrate has a plasma treated contact surface which is roughened, hydrophilic and has a higher oxygen atomic content than the interior portion. The treated contact surface has an enhanced cell adhesion, cell growth and cell recovery rate. During the treatment, the contact surface is contacted with a process gas introduced through a gas inlet near the treated surface and radio frequency electrical power is introduced in the process gas, forming a treated contact surface that has improved cell recovery compared to an untreated contact surface. The process gas optionally can be nitrogen gas, oxygen gas, or a gas that contains nitrogen atoms, oxygen atoms, or a combination of nitrogen and oxygen atoms. The process optionally improves cell recovery of a chicken embryo cell culture from the treated contact surface.

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