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1.发明申请
公开(公告)号：WO2020102434A3
公开(公告)日：2020-05-22
申请号：PCT/US2019/061293
申请日：2019-11-13
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： SADZEWICZ, Eugene , KELLY, Kenneth Wade , BALTAZAR, Martin , BREELAND, Adam , FISK, Thomas E. , HENTON, David , MAURER, Brian , TAHA, Ahmad , WEIKART, Christopher
Abstract: Disclosed are polymer vials (110, 210) and injection stretch blow molding methods for making the same. A polymer vial has a base (112) having a base surface area and a sidewall (114) extending up from the base. The base and sidewall define an interior (116) configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.
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公开(公告)号：WO2014052792A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/062247
申请日：2013-09-27
Applicant: SIO2 MEDICAL PRODUCTS, INC. , RESNICK, Paul R. , FISK, Thomas E. , WEIKART, Christopher
Inventor： RESNICK, Paul R. , FISK, Thomas E. , WEIKART, Christopher
CPC classification number: A61M5/31513 , A61J1/06 , A61M2005/3131 , A61M2207/00 , A61M2207/10 , C23C16/045 , C23C16/401
Abstract: A container, for example a syringe, cartridge, vial or similar article including a barrel or other vessel and a stopper, O-ring, plunger tip or piston. The vessel substrate defines a lumen and an internal sliding surface on the vessel substrate adjacent to the lumen. The stopper, O-ring, plunger tip or piston has an external sliding surface slidable in the lumen at least substantially in contact with the internal sliding surface. The internal sliding surface, the external sliding surface, or both are made at least in part of a parylene or halogenated polymer, which can be in the form of a coating or a bulk material. Methods of making the syringe, cartridge, or similar article using chemical vapor deposition, as by depositing the parylene or halogenated polymer directly or with intervening layers to define the external sliding surface, the internal internal sliding surface, or both are disclosed.
Abstract translation: 容器，例如注射器，药筒，小瓶或类似物品，其包括镜筒或其他容器和塞子，O形环，柱塞尖端或活塞。 容器衬底限定了与腔相邻的容器衬底上的管腔和内部滑动表面。 止动器O形环，柱塞尖端或活塞具有可在内腔中滑动至少基本上与内部滑动表面接触的外部滑动表面。 内部滑动表面，外部滑动表面或两者均至少部分由聚对二甲苯或卤化聚合物制成，其可以是涂层或散装材料的形式。 公开了通过使用化学气相沉积来制造注射器，药筒或类似物品的方法，如通过直接或间接沉积聚对二甲苯或卤化聚合物以限定外部滑动表面，内部内部滑动表面或两者。
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3.发明申请
公开(公告)号：WO2020102434A2
公开(公告)日：2020-05-22
申请号：PCT/US2019/061293
申请日：2019-11-13
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： SADZEWICZ, Eugene , KELLY, Kenneth Wade , BALTAZAR, Martin , BREELAND, Adam , FISK, Thomas E. , HENTON, David , MAURER, Brian , TAHA, Ahmad , WEIKART, Christopher
IPC: B29C49/48
Abstract: Disclosed are polymer vials and injection stretch blow molding methods for making the same. A polymer vial has a base having a base surface area and a sidewall extending up from the base. The base and sidewall define an interior configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.
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公开(公告)号：WO2014078666A4
公开(公告)日：2014-05-22
申请号：PCT/US2013/070325
申请日：2013-11-15
Applicant: SiO2 MEDICAL PRODUCTS, INC.
Inventor： FISK, Thomas E. , SAGONA, Peter J. , JONES, Joseph A.
Abstract: An apparatus and methods for testing the integrity of a barrier coating on a vessel. An off gas test fixture includes a face seal positioned about an opening of the vessel. A side seal is positioned about a portion of the vessel's wall and separated from the face seal by a space. Additionally, a cover may be secured to the fixture that encompasses an interface portion of the fixture and the vessel. Before and/or during testing, gas in the space between the side and face seals may be evacuated, as well as gas present in an interior area of the vessel. The vessel may be exposed to test gas(es) that is soluble by the plastic material of the vessel before and/or after being secured to the fixture. During testing, test gas(es) desorbed by the vessel may be evacuated, with the molecular flow being measured using a mass extraction unit.
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公开(公告)号：WO2014059012A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/064121
申请日：2013-10-09
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： KINNEY, Shawn , WEIKART, Christopher , HUNT, Benjamin , RAICHE, Adrian , FITZPATRICK, Brian , SAGONA, Peter J. , STEVENSON, Adam , FELTS, John T. , FISK, Thomas E.
CPC classification number: C23C16/50 , A61J1/065 , A61M2205/0238 , A61M2207/00 , A61M2209/06 , C23C16/045 , C23C16/401
Abstract: A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, a dispensing portion, and a shield. The shield is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the shield. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication between the barrel lumen and the dispensing portion lumen via the proximal opening at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.
Abstract translation: 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括筒体，分配部分和护罩的封盖预组件的筒体的内壁的至少一部分上。 屏蔽件被固定到筒体上，并且至少基本上将分配部分的远端开口与屏蔽外部的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在有效地通过在施加步骤结束时的近端开口保持筒内腔和分配部分内腔之间的连通的条件下施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。
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Patent Agency Ranking
公开(公告)号：WO2012125736A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029089
申请日：2012-03-14
Applicant: SIO2 MEDICAL PRODUCTS, INC. , FISK, Thomas E.
Inventor： FISK, Thomas E.
IPC: A61M5/31
CPC classification number: G01L1/24 , A61M5/3129 , A61M5/347 , A61M5/5086 , A61M2005/3104 , A61M2205/0294 , A61M2205/6081
Abstract: A medical device comprising a wall, a coating of SiO x , and a piezochromic material is disclosed. The piezochromic material is associated with the wall, and changes its appearance when the wall is exposed to mechanical stress exceeding a threshold intensity. Also disclosed is a method of interrogating a closed medical device for processing damage, comprising at least the acts of providing a closed medical device and inspecting the medical device. The medical device is inspected from the exterior for a change in the appearance of at least some of its piezochromic material that is characteristic of exposure of the wall to mechanical stress exceeding a threshold intensity greater than zero. Optionally in any embodiment inspecting is carried out using a spectrophotometer to determine the change in the color of at least some of its piezochromic material.
Abstract translation: 公开了包括壁，SiOx涂层和压敏变色材料的医疗装置。 压电变色材料与壁相关联，并且当壁暴露于超过阈值强度的机械应力时改变其外观。 还公开了询问用于处理损伤的封闭式医疗装置的方法，至少包括提供封闭的医疗装置和检查医疗装置的动作。 医疗设备从外部检查其至少一些其压电色素材料的外观变化，其特征在于壁的机械应力超过超过零的阈值强度。 可选地，在任何实施例中，使用分光光度计进行检查以确定其压电色素材料的至少一些的颜色变化。
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7.发明申请
公开(公告)号：WO2022251230A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030746
申请日：2022-05-24
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： ABRAMS, Robert S. , TAHA, Ahmad , SAGONA, Peter J. , BELL, Howard , BELL, Alexandra , COLLINS, Josh , FISK, Thomas E.
Abstract: The present disclosure is directed to pharmaceutical packages, such as syringes, vials, etc., containing wave-shifting crystals that, when excited, emit light having one or more characteristics by which information about the package, such as a unique package identifier, may be obtained. The wave-shifting crystals may be rare earth doped crystals. In some embodiments, the wave-shifting crystals may be incorporated into or onto a wall of a vessel, e.g. a syringe barrel or vial, in a way that maintains transparency of the vessel wall. In other embodiments, the wave-shifting crystals may be incorporated into or onto a portion of the package that need not be transparent, such as a needle shield, tip cap, or vial closure. The wave-shifting crystals may be used to track and/or authenticate a pharmaceutical package.
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公开(公告)号：WO2014085346A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/071750
申请日：2013-11-25
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： WEIKART, Christopher , CLARK, Becky L. , STEVENSON, Adam , ABRAMS, Robert S. , BELFANCE, John , JONES, Joseph A. , FISK, Thomas E.
CPC classification number: A61M5/3129 , A61M5/31513 , A61M2005/3131 , A61M2205/0222 , A61M2205/0238 , A61M2207/00 , A61M2207/10 , C23C16/045 , C23C16/401 , C23C16/505 , C23C16/52
Abstract: A method and apparatus for plasma modifying a workpiece such as a medical barrel, medical barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the generally cylindrical interior surface 16 of the generally cylindrical interior surface 16. A vessel made according to the process or using the apparatus described above. A pharmaceutical package comprising the medical barrel or vial containing a pharmaceutical preparation, secured with a closure.
Abstract translation: 描述了用于等离子体修饰诸如医疗镜筒，医疗镜筒，小瓶或血管的工件的方法和装置。 等离子体设置在工件的内腔内。 在对工件表面的等离子体改性有效的条件下提供等离子体。 在内腔的至少一部分设有磁场。 磁场具有有效地改善大致圆柱形内表面16的大致圆柱形内表面16的等离子体改性的均匀性的取向和场强。根据该方法或使用上述装置制造的容器。 一种药物包装，其包含含有封闭物固定的药物制剂的医疗桶或小瓶。
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公开(公告)号：WO2014008138A2
公开(公告)日：2014-01-09
申请号：PCT/US2013/048709
申请日：2013-06-28
Applicant: SIO2 MEDICAL PRODUCTS, INC.
Inventor： WEIKART, Christopher , FELTS, John T. , FISK, Thomas E. , ABRAMS, Robert S. , FERGUSON, John , FREEDMAN, Jonathan R. , PANGBORN, Robert J. , SAGONA, Peter J.
CPC classification number: C23C16/045 , A61J1/00 , A61J1/05 , A61M5/3129 , A61M2005/3131 , C23C16/401
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公开(公告)号：WO2013170044A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040368
申请日：2013-05-09
Applicant: SiO2 MEDICAL PRODUCTS, INC. , FELTS, John T. , FISK, Thomas E. , ABRAMS, Robert S. , FERGUSON, John , FREEDMAN, Jonathon R. , PANGBORN, Robert J. , SAGONA, Peter J. , WEIKART, Christopher
Inventor： FELTS, John T. , FISK, Thomas E. , ABRAMS, Robert S. , FERGUSON, John , FREEDMAN, Jonathon R. , PANGBORN, Robert J. , SAGONA, Peter J. , WEIKART, Christopher
CPC classification number: G01N21/8422 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150992 , A61B5/153 , A61B5/154 , A61M5/3129 , A61M2005/3131 , C23C16/50 , C23C16/52 , G01B21/08 , G01G19/00 , G01G19/414 , G01N15/082 , G01N2021/8427 , G01N2033/0096 , G01N2201/06113
Abstract: A method for inspecting the product of a coating process is provided. In certain embodiments, the release of at least one volatile species from the coated surface into the gas space adjacent to the coated surface is measured and the result is compared with the result for at least one reference object measured under the same test conditions. Microbalance weighing methods are also disclosed to detect and distinguish among PECVD coatings. Thus the presence or absence of the coating, and/or a physical and/or chemical property of the coating can be determined. The method is useful for inspecting any coated articles, e.g. vessels. Its application on the inspection of PECVD coatings made from organosilicon precursors, especially of barrier coatings, is also disclosed.
Abstract translation: 提供了一种用于检查涂布工艺的产品的方法。 在某些实施方案中，测量至少一种挥发性物质从涂覆表面释放到与涂覆表面相邻的气体空间中，并将结果与在相同测试条件下测量的至少一个参考对象的结果进行比较。 还公开了微量天平称重方法来检测和区分PECVD涂层。 因此，可以确定涂层的存在或不存在，和/或涂层的物理和/或化学性质。 该方法可用于检查任何涂层制品，例如， 船只。 还公开了其用于检查由有机硅前体，特别是阻隔涂层制成的PECVD涂层的应用。
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