-
公开(公告)号：WO2021072410A2
公开(公告)日：2021-04-15
申请号：PCT/US2020/055440
申请日：2020-10-13
IPC分类号： C23C16/04 , B01L3/00 , A61B5/15 , A61B5/154 , C23C28/04 , C23C16/30 , C23C16/40 , A61B5/15003 , A61B5/150274 , A61B5/150755 , C23C16/045 , C23C16/401
摘要： Blood sample collection tubes are described including a tube surface and a coating set comprising a tie coating or layer of SiOxCy or SiNxCy applied to the tube surface, a barrier coating or layer of SiOx, and a pH protective layer of SiOxCy or SiNxCy. The tubes optionally contain a fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic tube, and the tie coating or layer and pH protective coating or layer together protect the barrier layer from the contents of the tube. Processes of collecting high volumes of blood into the tube, and methods of isolating the various types of nucleic acids from the collected blood sample are described.
-
公开(公告)号：WO2020092373A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058571
申请日：2019-10-29
摘要： A primary drug container is described having an injection-molded thermoplastic wall having an internal surface defining a lumen, a PECVD (plasma-enhanced chemical vapor deposition) drug-contact coating, and a polypeptide composition contained in the lumen. The drug-contact coating is on or adjacent to the internal surface, positioned to contact a fluid in the lumen, and consists essentially of SiOxCyHz. The primary drug container contains between a lower limit of 1,000 and an upper limit of 100,000 particles having effective spherical diameters greater than 2 and no more than 10 micrometers (µm) per mL of solution.
-
3.发明申请
公开(公告)号：WO2018194918A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/027452
申请日：2018-04-13
CPC分类号： A61M5/31 , A61J1/05 , A61J1/1468 , A61M2205/0238 , C23C16/0272 , C23C16/30 , C23C16/36 , C23C16/401
摘要： A method for preventing or reducing reaction of radiation sterilization-generated free radicals and/or byproducts thereof and/or oxygen with contents of a primary vessel is provided. A radiation sterilized primary plastic vessel contains contents prone to degradation by free radicals and/or byproducts thereof and/or oxygen. The vessel has a coating set deposited on an inner wall. The coating set is effective to protect the contents from degradation by radiation sterilization-generated free radicals and/or byproducts thereof and/or oxygen located in the plastic of the vessel and/or on the inner wall.
-
4.发明申请PRE-FILLED PHARMACEUTICAL PACKAGE COMPRISING A LIQUID FORMULATION OF A VEGF-ANTAGONIST 审中-公开包含VEGF-拮抗剂液体制剂的预装药物包装
公开(公告)号：WO2017087798A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062767
申请日：2016-11-18
发明人： BROCKMEYER, Carsten , WEIKART, Christopher , BENNETT, Murray Stephen , GIRAUD, Jean-Pierre , STRÜNGMANN, Thomas
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K9/0019 , A61K38/179 , A61K39/39591 , A61M2005/3131 , C07K2317/24 , C07K2317/55 , C07K2317/76 , C07K2319/30
摘要： A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.
摘要翻译： 预填充药物包装，其在预填充的药物包装例如注射器，药筒或小瓶中包含VEGF拮抗剂（例如Ranibizumab）的液体制剂，部分或 在整个热塑性聚合物中，在内部涂有粘结涂层或涂层，阻隔涂层或涂层，pH保护涂层或涂层，以及任选的润滑涂层或涂层。 包被在包被的COP容器中的VEGF-拮抗剂的稳定性能与玻璃相当或比玻璃更好。
-
公开(公告)号：WO2022026586A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/043516
申请日：2021-07-28
IPC分类号： C08J7/06 , C03C17/34 , C23C16/04 , C23C16/26 , C23C16/30 , A61M5/31 , A61J1/1468 , A61M2005/3131 , A61M5/31513 , C03C17/004 , C03C17/22 , C03C17/225 , C03C17/245 , C03C17/30 , C03C17/3441 , C03C2218/153 , C23C16/045 , C23C16/401 , C23C16/50
摘要： The present disclosure is directed to a vessel having a lumen defined at least in part by a wall, the wall having an interior surface facing the lumen, and the interior surface comprising a coating. The coating is configured to prevent the leaching of metal ions from the vessel wall into a fluid contained within the lumen and stored in contact with the coating. The vessels are used to store an aqueous drug product, typically an aqueous drug product containing an active agent and one or more exceipients, such as a polysorbate stabilizer. The coated vessels are effective to reduce degradation of the active agent and/or one or more excipients, e.g. a polysorbate stabilizer.
-
公开(公告)号：WO2021216353A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/027573
申请日：2021-04-15
发明人： PICCIRILLI, Joseph , WEIKART, Christopher , KLIBANOV, Alexander M. , HEXOM, Tia , NUNEZ, Brandy
IPC分类号： C12N15/10
摘要： This disclosure is directed to nucleic acid and cell preservative compositions. Methods of preserving nucleic acids and/or cells in a blood or other biological sample, and kits for preserving nucleic acids and/or cells in a blood or other biological sample are also described.
-
7.发明申请
公开(公告)号：WO2020102434A3
公开(公告)日：2020-05-22
申请号：PCT/US2019/061293
申请日：2019-11-13
发明人： SADZEWICZ, Eugene , KELLY, Kenneth Wade , BALTAZAR, Martin , BREELAND, Adam , FISK, Thomas E. , HENTON, David , MAURER, Brian , TAHA, Ahmad , WEIKART, Christopher
摘要： Disclosed are polymer vials (110, 210) and injection stretch blow molding methods for making the same. A polymer vial has a base (112) having a base surface area and a sidewall (114) extending up from the base. The base and sidewall define an interior (116) configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.
-
公开(公告)号：WO2014052792A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/062247
申请日：2013-09-27
CPC分类号： A61M5/31513 , A61J1/06 , A61M2005/3131 , A61M2207/00 , A61M2207/10 , C23C16/045 , C23C16/401
摘要： A container, for example a syringe, cartridge, vial or similar article including a barrel or other vessel and a stopper, O-ring, plunger tip or piston. The vessel substrate defines a lumen and an internal sliding surface on the vessel substrate adjacent to the lumen. The stopper, O-ring, plunger tip or piston has an external sliding surface slidable in the lumen at least substantially in contact with the internal sliding surface. The internal sliding surface, the external sliding surface, or both are made at least in part of a parylene or halogenated polymer, which can be in the form of a coating or a bulk material. Methods of making the syringe, cartridge, or similar article using chemical vapor deposition, as by depositing the parylene or halogenated polymer directly or with intervening layers to define the external sliding surface, the internal internal sliding surface, or both are disclosed.
摘要翻译： 容器，例如注射器，药筒，小瓶或类似物品，其包括镜筒或其他容器和塞子，O形环，柱塞尖端或活塞。 容器衬底限定了与腔相邻的容器衬底上的管腔和内部滑动表面。 止动器O形环，柱塞尖端或活塞具有可在内腔中滑动至少基本上与内部滑动表面接触的外部滑动表面。 内部滑动表面，外部滑动表面或两者均至少部分由聚对二甲苯或卤化聚合物制成，其可以是涂层或散装材料的形式。 公开了通过使用化学气相沉积来制造注射器，药筒或类似物品的方法，如通过直接或间接沉积聚对二甲苯或卤化聚合物以限定外部滑动表面，内部内部滑动表面或两者。
-
公开(公告)号：WO2013170052A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040380
申请日：2013-05-09
申请人： SIO2 MEDICAL PRODUCTS, INC. , FELTS, John, T. , FISK, Thomas, E. , ABRAMS, Robert, S. , FERGUSON, John , FREEDMAN, Jonathan, R. , PANGBORN, Robert, J. , SAGONA, Peter , WEIKART, Christopher , ISRAELACHVILI, Jacob
发明人： FELTS, John, T. , FISK, Thomas, E. , ABRAMS, Robert, S. , FERGUSON, John , FREEDMAN, Jonathan, R. , PANGBORN, Robert, J. , SAGONA, Peter , WEIKART, Christopher , ISRAELACHVILI, Jacob
CPC分类号： A61J1/1468 , A61J1/00 , A61J1/05 , A61J1/2096 , A61J2200/50 , A61L31/10 , A61L2400/10 , A61L2420/08 , A61M3/0262 , Y10T428/1383
摘要： A method for providing a saccharide based lubricating or protective coating or layer on a substrate surface is provided. In particular, a lubricity and/or protective coating or layer made by said method is provided. Pharmaceutical packages or other vessels coated by said method and the use of such pharmaceutical packages or other vessels protecting a compound or composition contained or received in said vessel with a protective coating against mechanical and/or chemical effects of the surface of the vessel without a protective coating material are also provided.
摘要翻译： 提供了一种在基材表面上提供基于糖的润滑或保护涂层或层的方法。 特别地，提供了由所述方法制成的润滑性和/或保护性涂层或层。 通过所述方法涂覆的药物包装或其它容器以及使用这种药物包装或其他容器保护含有或接收在所述容器中的化合物或组合物的保护性涂层免受容器表面的机械和/或化学作用而没有保护 还提供涂料。
-
10.发明申请
公开(公告)号：WO2020102434A2
公开(公告)日：2020-05-22
申请号：PCT/US2019/061293
申请日：2019-11-13
发明人： SADZEWICZ, Eugene , KELLY, Kenneth Wade , BALTAZAR, Martin , BREELAND, Adam , FISK, Thomas E. , HENTON, David , MAURER, Brian , TAHA, Ahmad , WEIKART, Christopher
IPC分类号： B29C49/48
摘要： Disclosed are polymer vials and injection stretch blow molding methods for making the same. A polymer vial has a base having a base surface area and a sidewall extending up from the base. The base and sidewall define an interior configured to house product, the sidewall narrowing at an upper section of the vial to form a neck leading to an opening that provides access to the interior. The vial is optionally round and symmetrical about a central axis, a lower portion of the sidewall including a first surface that is outwardly curved along a first radius having an imaginary center positioned within the vial. The base is positioned below the first surface and is substantially flat such that at least 80% of the base surface area has a standing base surface occupying a single plane.
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.019 秒)
