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    IMPROVEMENTS IN AND RELATING TO POLYMER MATERIALS
    1.
    发明申请
    IMPROVEMENTS IN AND RELATING TO POLYMER MATERIALS 审中-公开
    与聚合物材料相关的改进

    公开(公告)号：WO2017121873A1

    公开(公告)日：2017-07-20

    申请号：PCT/EP2017/050711

    申请日：2017-01-13

    Applicant: SMITH & NEPHEW PLC

    Inventor： HICKS, John, Kenneth ,  HOSKINS, Richard ,  RIMMER, Stephen ,  MCCULLOCH, Dorothy

    IPC: A61B5/145 ,  A61F13/00 ,  A61L15/22 ,  A61L15/56 ,  C08G18/48 ,  C08G18/73 ,  C08G18/76 ,  C08G18/10 ,  C08G18/24 ,  C08G18/28 ,  C08L75/04

    CPC classification number: C08L75/04 ,  A61B5/14539 ,  A61F13/00063 ,  A61L15/225 ,  A61L15/56 ,  C08G18/10 ,  C08G18/244 ,  C08G18/246 ,  C08G18/283 ,  C08G18/4837 ,  C08G18/73 ,  C08G18/7664 ,  C08L2205/04 ,  C08L33/26 ,  C08L33/02 ,  C08G18/3206

    Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

    Abstract translation: 用于指示某一地点的pH，优选地作为微生物存在的指示的聚氨酯材料，其包含其中固定有一种或多种亲水性共聚物的聚氨酯网络，所述或每种所述共聚物包含：亲水性单体; 并指示单体，其响应所述亲水单体和/或共聚物的亲水状态的变化提供指示; 其特征在于所述共聚物或每种共聚物还包含一个或多个可离子化基团或部分或可聚合单体，所述可离子化基团或部分或可聚合单体具有一个或多个5至10范围内的特征性pKa值并且响应pH5至pH范围内所述基因座处的pH 并且亲水性共聚物的亲水状态取决于所述可电离基团，部分或单体的电离; 包含该材料和其制备方法的试剂盒和装置; 并用于检测或检测微生物或pH值。

    IMPROVEMENTS IN AND RELATING TO DEVICES
    2.
    发明申请
    IMPROVEMENTS IN AND RELATING TO DEVICES 审中-公开

    公开(公告)号：WO2016012219A3

    公开(公告)日：2016-01-28

    申请号：PCT/EP2015/065227

    申请日：2015-07-03

    Applicant: SMITH & NEPHEW PLC

    Inventor： HICKS, John, Kenneth ,  RIMMER, Stephen ,  HOSKINS, Richard ,  MCCULLOCH, Dorothy

    IPC: C08L75/04 ,  A61L27/16 ,  A61L27/22 ,  A61L27/26 ,  C08G18/10 ,  G01N21/01 ,  G01N21/77 ,  G01N21/80

    Abstract: A device for sensing and/or detecting species or stimulus at a locus, preferably at a fluid or moist locus by means of fluid communication therewith, comprising a surface configured to contact the locus, wherein the surface comprises a polyurethane material which material comprises a polyurethane polymer network having a hydrophilic polymer immobilised therein wherein the hydrophilic polymer comprises immobilised therein a ligand or moiety for detecting or sensing species or stimulus and an indicator for indicating detection or sensing prior to contact with the locus and change in indication as a function of species or stimulus present at the locus wherein species or stimulus are selected from chemical and biological species or stimulus; the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; and a Kit.

    DEVICE AND KIT FOR INDICATING A PH AT A LOCUS
    3.
    发明申请
    DEVICE AND KIT FOR INDICATING A PH AT A LOCUS 审中-公开
    用于指示位于某处的PH值的装置和套件

    公开(公告)号：WO2017121871A1

    公开(公告)日：2017-07-20

    申请号：PCT/EP2017/050704

    申请日：2017-01-13

    Applicant: SMITH & NEPHEW PLC

    Inventor： HICKS, John, Kenneth ,  HOSKINS, Richard ,  RIMMER, Stephen ,  MCCULLOCH, Dorothy

    IPC: A61F13/00 ,  G01N31/22 ,  A61F13/84

    CPC classification number: A61F13/00055 ,  A61F13/8405 ,  G01N31/221

    Abstract: Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having 5 immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; 10 characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said 15 ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

    Abstract translation: 包含聚氨酯材料的装置，所述聚氨酯材料用于指示位置处的pH，优选作为微生物存在的指示，所述装置包含聚氨酯网络，所述聚氨酯网络具有固定在其中的一种或多种亲水共聚物，所述或每种所述共聚物包含：亲水单体 ; 和指示剂单体，其提供响应于所述亲水性单体和/或共聚物的亲水状态变化的指示; 其特征在于所述共聚物或每种共聚物还包含一个或多个可离子化基团或部分或可聚合单体，所述可离子化基团或部分或可聚合单体具有一个或多个5至10范围内的特征性pKa值并且对所述基因座处pH为5至10 pH10并且亲水共聚物的亲水状态取决于所述可电离基团，部分或单体的电离; 包含该材料和其制备方法的试剂盒和装置; 并用于检测或检测微生物或pH值。

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