中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.018 seconds)

    DOSIMETER FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS
    1.
    发明申请
    DOSIMETER FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS 审中-公开
    用于流体可编程微操作的DOSMETER

    公开(公告)号：WO2007057788A3

    公开(公告)日：2007-11-22

    申请号：PCT/IB2006004006

    申请日：2006-06-05

    Applicant: SPINX INC ,  ZUCCHELLI PIERO ,  VAN DER VYVER BART

    Inventor： ZUCCHELLI PIERO ,  VAN DER VYVER BART

    IPC: B01L3/00 ,  B01F11/00 ,  B01F13/00 ,  B01F13/08 ,  B01F15/02

    CPC classification number: B01L3/50273 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N35/00069 ,  Y10T137/1632 ,  Y10T137/1812 ,  Y10T137/2224 ,  Y10T436/111666 ,  Y10T436/2575

    Abstract: The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components allowing volumetric quantitation of fluids. Using the perforation of the material functionality such as metering and multiplexing are achieved on a microscale. This functionality is achieved through basic operations, like dosimeters filling, dosimeters purging, dosimeters extraction, dosimeters ventilation and channels routing. Accordingly, these operations are performed in microfluidic platforms and are characterized extensively, allowing the realization of complex assays in a miniaturized format, where dilutions of proteins and assay readout can be performed in an extremely small footprint.

    Abstract translation: 本发明总体上涉及用于以可编程方式控制介观尺度流体部件中的流体流动的装置和方法。 具体而言，本发明涉及一种用于将两个微流体部件以任意位置和时间流体连通的装置和方法，两者都在外部限定。 本发明的设备使用电磁辐射穿孔具有选择的吸附性质的材料层。 材料层的穿孔允许微流体组分之间的流体连通，允许流体的体积定量。 使用材料功能的穿孔，例如计量和多路复用，可以在微型计算机上实现。 该功能通过基本操作实现，如剂量计灌装，剂量计清洗，剂量计提取，剂量计通风和通道布线。 因此，这些操作在微流体平台中进行并且被广泛表征，允许以小型化的格式实现复杂的测定，其中蛋白质的稀释和测定读数可以在极小的足迹中进行。

    SIPHONING AS A WASHING METHOD AND APPARATUS FOR HETEROGENENOUS ASSAYS
    2.
    发明申请
    SIPHONING AS A WASHING METHOD AND APPARATUS FOR HETEROGENENOUS ASSAYS 审中-公开
    作为洗涤方法和装置用于异源测定

    公开(公告)号：WO2011051821A3

    公开(公告)日：2011-06-30

    申请号：PCT/IB2010003302

    申请日：2010-10-29

    Applicant: SPINX INC ,  ZUCCHELLI PIERO

    Inventor： ZUCCHELLI PIERO

    IPC: B01L3/00

    CPC classification number: B01L3/50273 ,  B01L2200/0647 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0683

    Abstract: A fluidic tile having a first substrate containing macrofluidic structures bonded to a second substrate containing microfluidic structures. The microfluidic structures correspond to the macrofluidic structures in the first substrate and provide fluid flow paths between the macrofluidic structures. One of the microfluidic structures is a washing siphon that provides a fluid flow path between a purification chamber and a waste chamber. The washing siphon is configured to be primed when a volume of liquid in the purification chamber exceeds a predetermined amount causing the washing siphon to initiate transfer of the liquid in the purification chamber to the waste chamber when the volume of the liquid in the purification chamber exceeds the predetermined amount.

    Abstract translation: 流体瓦片，其具有含有结合到含有微流体结构的第二基底的大流动结构的第一基底。 微流体结构对应于第一基底中的大流体结构并提供在大流动结构之间的流体流动路径。 微流体结构之一是洗涤虹吸管，其在净化室和废物室之间提供流体流动路径。 当净化室中的液体体积超过预定量时，洗涤虹吸被配置为引发，当净化室中的液体的体积超过净化室时，洗涤虹吸引发净化室中的液体转移到废物室 预定量。

    DEVICES AND METHODS FOR PRODUCTION OF HIGH-PRECISION, MULTI-COMPONENT DEVICES
    3.
    发明申请
    DEVICES AND METHODS FOR PRODUCTION OF HIGH-PRECISION, MULTI-COMPONENT DEVICES 审中-公开
    用于生产高精度，多分量器件的器件和方法

    公开(公告)号：WO2010043966A2

    公开(公告)日：2010-04-22

    申请号：PCT/IB2009007305

    申请日：2009-10-15

    Applicant: SPINX INC ,  ZUCCHELLI PIERO ,  LETTIERI GIAN-LUCA ,  O'KEANE MARTIN ,  HORAK GIORGIO

    Inventor： ZUCCHELLI PIERO ,  LETTIERI GIAN-LUCA ,  O'KEANE MARTIN ,  HORAK GIORGIO

    IPC: B81C3/00

    CPC classification number: B81C3/001 ,  B81B2201/058 ,  B81C2203/038 ,  B81C2203/051

    Abstract: The novel use of isostatic pressing or high energy rate forming in the production of high precision, multi-component devices for a variety of applications including, but not limited to, the domains of microfluidics, microtechnology, medical devices, biotechnology, life sciences and engineering. The high precision of said devices is not necessarily related to the dimensional accuracy of the device itself, although this could be a feature, but rather to the precision of the alignment of the sub-components with respect to each other in the final device. This production process has numerous advantages, including low recurring manufacturing costs, high throughput, large production capacity, homogeneous product quality and ease of process control.

    Abstract translation: 在生产用于各种应用的高精度多组分装置中的等静压或高能量成形的新颖应用，包括但不限于微流体，微技术，医疗器械，生物技术，生命科学和工程领域 。 所述装置的高精度并不一定与装置自身的尺寸精度有关，尽管这可能是一个特征，但是与最终装置中的子部件相对于彼此的对准精度相关。 该生产工艺具有生产成本低，生产能力强，生产能力大，产品质量均匀，工艺控制便利等优点。

    MICROFLUIDIC DEVICES AND METHODS FOR PROTEINS CRYSTALLIZATION AND IN SITU X-RAY DIFFRACTION
    5.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS FOR PROTEINS CRYSTALLIZATION AND IN SITU X-RAY DIFFRACTION 审中-公开
    蛋白质结晶和X射线衍射的微流体装置和方法

    公开(公告)号：WO2009150549A3

    公开(公告)日：2010-04-01

    申请号：PCT/IB2009006586

    申请日：2009-06-15

    Applicant: SPINX INC ,  ZUCCHELLI PIERO

    Inventor： ZUCCHELLI PIERO

    IPC: B01L3/06 ,  B01D9/00 ,  B01L3/00 ,  C30B7/00 ,  C30B29/58

    CPC classification number: B01L3/06 ,  B01D9/00 ,  B01D9/0072 ,  B01D9/0077 ,  B01L3/5025 ,  B01L3/5027 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0854 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0409 ,  B01L2400/0683 ,  C30B7/00 ,  C30B29/58

    Abstract: The present disclosure is directed generally to devices and methods with the purpose of interfacing micro fluidic devices with dispensing and fluid handling systems to achieve the rapid identification of protein crystallization conditions. The device described herein is fabricated with the use of a cyclic olefin homopolymer-based creating microfluidics system adaptable for protein crystallization and in situ X-ray diffraction. Connectivity between chambers is controlled by valves that allow specified volumes of liquid to be transferred from one chamber to another. The microfluidic system is useful to established microbatch, vapor diffusion and free interface diffusion protocols for protein crystallization and to obtain crystals for a number of proteins, including chicken lysozyme, bovine trypsin, a human p53 protein containing both the DNA binding and oligomerization domains bound to DNA and a functionally important domain of Arabidopsis Morpheus' Molecule 1 (MOMl). For X-ray diffraction analysis, either the microfluidic devices were opened to allow mounting of the crystals on loops or the crystals were exposed to X-rays in situ. Thus, cyclic olefin homopolymer-based microfluidics systems are useful to further automate protein crystallization and structural genomics efforts.

    Abstract translation: 本公开通常涉及用于将微流体装置与分配和流体处理系统接合以实现蛋白质结晶条件的快速鉴定的装置和方法。 本文描述的装置使用适用于蛋白质结晶和原位X射线衍射的基于环烯烃均聚物的产生微流体系统来制造。 室之间的连通性由阀控制，允许指定体积的液体从一个室转移到另一个室。 微流体系统可用于建立蛋白质结晶的微批，蒸汽扩散和自由界面扩散方案，并获得许多蛋白质的晶体，包括鸡溶菌酶，牛胰蛋白酶，含有结合到DNA结合和寡聚结构域的人p53蛋白 DNA和功能重要的拟南芥Morpheus分子1（MOM1）的结构域。 对于X射线衍射分析，打开微流体装置以允许将晶体安装在环上或将晶体原位暴露于X射线。 因此，环烯烃均聚物基微流体系统可用于进一步自动化蛋白质结晶和结构基因组学研究。

Patent Agency Ranking