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    SELF-GELLING SOLUTIONS FOR ADMINISTRATION OF THERAPEUTICS TO THE INNER EAR
    1.
    发明申请
    SELF-GELLING SOLUTIONS FOR ADMINISTRATION OF THERAPEUTICS TO THE INNER EAR 审中-公开

    公开(公告)号：WO2020146640A1

    公开(公告)日：2020-07-16

    申请号：PCT/US2020/012942

    申请日：2020-01-09

    Applicant: SPIRAL THERAPEUTICS, INC.

    Inventor： HERRERO, Carmen ,  AYOOB, Andrew ,  HANES, Justin ,  PERIS, Hugo

    IPC: A61K9/00 ,  A61K9/19 ,  A61K31/00

    Abstract: A solution for sustained release of therapeutic, prophylactic and/or diagnostic agent in the inner ear has been developed. The formulation can be injected through a small gauge needle into the inner ear, where it gels to form a sustained release depot for controlled delivery of drug over a few days. In the preferred embodiment, the formulation includes a thermoresponsive sol-gel polymer such as POLOXAMER 407 which forms a stable hydrogel after trans-tympanic injection. As demonstrated by the examples, the hydrogel provides sustained release of an apoptosis inhibitory agent, LPT99, an anti-apoptosis agent that inhibits apoptotic protease activating factor 1 (APAF-1), as well as safety and efficacy in in vitro and in vivo models.

    TREATMENT OF OTIC DISEASES AND CONDITIONS
    2.
    发明申请
    TREATMENT OF OTIC DISEASES AND CONDITIONS 审中-公开

    公开(公告)号：WO2021163610A1

    公开(公告)日：2021-08-19

    申请号：PCT/US2021/018019

    申请日：2021-02-12

    Applicant: SPIRAL THERAPEUTICS INC. ,  DE JUAN, Eugene ,  AYOOB, Andrew ,  ERICKSON, Signe ,  FARINAS, Kathleen

    Inventor： DE JUAN, Eugene ,  AYOOB, Andrew ,  ERICKSON, Signe ,  FARINAS, Kathleen

    IPC: A61K31/7088 ,  A61K45/00 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/02

    Abstract: Active agents that bind to VEGF or a VEGF receptor and reduce the severity of a condition associated with BLB disruption and/or angiogenesis, for example anti-VEGF antibodies or tyrosine kinase inhibitor small molecules, can be locally, regionally or systemically administered to an individual with an otic disease or condition, such as Ménière's Disease, Autoimmune Inner Ear Disease, sensorineural hearing loss and noise-induced hearing loss, to alleviate symptoms of the disease or condition, for example, due to edema and endolymphatic dysfunction. An effective amount of these compounds can be delivered by intratympanic or intracochlear administration. Other methods of administration include, but are not limited to, topical, parenteral, subcutaneous, intraperitoneal and intranasal. Formulations may be, for example, for immediate release, sustained release, or controlled release.

    INTRATYMPANIC INJECTOR DEVICES AND NEEDLES FOR DELIVERY OF DRUGS AND METHODS OF USE
    4.
    发明申请
    INTRATYMPANIC INJECTOR DEVICES AND NEEDLES FOR DELIVERY OF DRUGS AND METHODS OF USE 审中-公开

    公开(公告)号：WO2020176419A1

    公开(公告)日：2020-09-03

    申请号：PCT/US2020/019517

    申请日：2020-02-24

    Applicant: SPIRAL THERAPEUTICS, INC.

    Inventor： SACHERMAN, Kevin W. ,  AYOOB, Andrew ,  ERICKSON, Signe ,  PERIS, Hugo ,  LIMB, Charles ,  DE JUAN, Jr., Eugene

    IPC: A61M5/32 ,  A61B1/227 ,  A61F11/00

    Abstract: A system for delivering one or more therapeutics to a region of the ear, the region being internal to a tympanic membrane. The system includes a canal guide configured to be inserted within and fittingly engaged with walls of the ear canal and needle assembly having a flexible shaft sized to extend through the canal guide. The canal guide provides alignment of the needle assembly within the ear canal relative to the tympanic membrane. The canal guide includes a viewing lumen extending between a proximal end to a distal-most end of the canal guide and is sized to remain external to the tympanic membrane. The canal guide includes a guide lumen extending to a distal opening near the distal-most end of the canal guide. The guide lumen curves from a first axis to a second axis. Related devices, systems, and methods are provided.

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