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    TREATMENT OF OTIC DISEASES AND CONDITIONS
    1.
    发明申请
    TREATMENT OF OTIC DISEASES AND CONDITIONS 审中-公开

    公开(公告)号：WO2021163610A1

    公开(公告)日：2021-08-19

    申请号：PCT/US2021/018019

    申请日：2021-02-12

    Applicant: SPIRAL THERAPEUTICS INC. ,  DE JUAN, Eugene ,  AYOOB, Andrew ,  ERICKSON, Signe ,  FARINAS, Kathleen

    Inventor： DE JUAN, Eugene ,  AYOOB, Andrew ,  ERICKSON, Signe ,  FARINAS, Kathleen

    IPC: A61K31/7088 ,  A61K45/00 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/02

    Abstract: Active agents that bind to VEGF or a VEGF receptor and reduce the severity of a condition associated with BLB disruption and/or angiogenesis, for example anti-VEGF antibodies or tyrosine kinase inhibitor small molecules, can be locally, regionally or systemically administered to an individual with an otic disease or condition, such as Ménière's Disease, Autoimmune Inner Ear Disease, sensorineural hearing loss and noise-induced hearing loss, to alleviate symptoms of the disease or condition, for example, due to edema and endolymphatic dysfunction. An effective amount of these compounds can be delivered by intratympanic or intracochlear administration. Other methods of administration include, but are not limited to, topical, parenteral, subcutaneous, intraperitoneal and intranasal. Formulations may be, for example, for immediate release, sustained release, or controlled release.

    INTRATYMPANIC INJECTOR DEVICES AND NEEDLES FOR DELIVERY OF DRUGS AND METHODS OF USE
    3.
    发明申请
    INTRATYMPANIC INJECTOR DEVICES AND NEEDLES FOR DELIVERY OF DRUGS AND METHODS OF USE 审中-公开

    公开(公告)号：WO2020176419A1

    公开(公告)日：2020-09-03

    申请号：PCT/US2020/019517

    申请日：2020-02-24

    Applicant: SPIRAL THERAPEUTICS, INC.

    Inventor： SACHERMAN, Kevin W. ,  AYOOB, Andrew ,  ERICKSON, Signe ,  PERIS, Hugo ,  LIMB, Charles ,  DE JUAN, Jr., Eugene

    IPC: A61M5/32 ,  A61B1/227 ,  A61F11/00

    Abstract: A system for delivering one or more therapeutics to a region of the ear, the region being internal to a tympanic membrane. The system includes a canal guide configured to be inserted within and fittingly engaged with walls of the ear canal and needle assembly having a flexible shaft sized to extend through the canal guide. The canal guide provides alignment of the needle assembly within the ear canal relative to the tympanic membrane. The canal guide includes a viewing lumen extending between a proximal end to a distal-most end of the canal guide and is sized to remain external to the tympanic membrane. The canal guide includes a guide lumen extending to a distal opening near the distal-most end of the canal guide. The guide lumen curves from a first axis to a second axis. Related devices, systems, and methods are provided.

    INNER EAR DRUG DELIVERY DEVICES AND METHODS OF USE
    4.
    发明申请
    INNER EAR DRUG DELIVERY DEVICES AND METHODS OF USE 审中-公开

    公开(公告)号：WO2019204653A1

    公开(公告)日：2019-10-24

    申请号：PCT/US2019/028189

    申请日：2019-04-18

    Applicant: SPIRAL THERAPEUTICS, INC.

    Inventor： SACHERMAN, Kevin, W. ,  ERICKSON, Signe ,  PERIS, Hugo ,  DE JUAN, Jr., Eugene

    IPC: A61F11/00

    Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.

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